Navicixizumab
Based on 1 Customer Validation
Navicixizumab (OMP-305B83) is a bispecific anti-VEGF and anti-DLL4 inhibitory antibody. Navicixizumab can combine with Paclitaxel (HY-B0015) for cancer research. Navicixizumab can be used in the research of ovarian, primary peritoneal, or fallopian tube cancer.
For research use only. We do not sell to patients.
- Purity: 99.83%
- CAS No.: 1638338-43-8
- Molecular Weight:145.83 kDa
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
Biological Activity
Human IgG2 kappa
Human
DLL4 & VEGFA
Navicixizumab (0-100 μM) reduces proliferation of human endothelial cells in the presence of hVEGF[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
| NCT Number | Sponsor | Condition | Start Date |
Phase
|
|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
Unconjugated
The product can be reconstituted/diluted with sterile PBS or saline.
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Human IgG2 kappa
ELISA, FACS, Functional assay
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Immobilized Delta-like protein 4/DLL4 Protein, Human (HEK293, HY-P72972) can bind Navicixizumab. The EC50 for this effect is 20.88 ng/mL. -
Immobilized VEGF165 Protein, Human (P.pastoris, HY-P7110) can bind Navicixizumab. The EC50 for this effect is 4.41 ng/mL. -
Flow cytometric analysis of 1X106 HeLa cells with Navicixizumab (HY-P99377, red). Cells were fixed with 4% paraformaldehyde. Then stained with the primary antibody at 1/200 dilution for an hour at 4℃. AF 488-conjugated AffiniPure Goat Anti-Human IgG H&L (HY-P83776) was used as the secondary antibody at 1/1,000 dilution for 30 minutes at 4℃. Human IgG2 kappa (HY-P99002, blue) was used as the isotype control.
Chemical Information
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CAS No. 1638338-43-8
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Appearance Liquid
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Molecular Weight 145.83 kDa
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Color Colorless to light yellow
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SMILES
[Navicixizumab]
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Synonyms
OMP-305B83; Anti-DLL4 Reference Antibody (navicixizumab)
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Shipping
Shipping with dry ice.
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Formulation
Please refer to the lot-specific COA for specific buffer information.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
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Data Sheet (258 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Inhibitory Antibodies User Guide (603 KB)
References
[1]. Fu S, et al. Phase Ib Study of Navicixizumab Plus Paclitaxel in Patients With Platinum-Resistant Ovarian, Primary Peritoneal, or Fallopian Tube Cancer. J Clin Oncol. 2022 Aug 10;40(23):2568-2577. [Content Brief]
[2]. Perez-Fidalgo JA, et al. NOTCH signalling in ovarian cancer angiogenesis. Ann Transl Med. 2020 Dec;8(24):1705. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)