NCATS-SM1441

製品番号: HY-151243 純度: 98.65%: Data Sheet SDS COA 取扱説明書
FAQs
Technical Support

NCATS-SM1441 (compound 52) is a lactate dehydrogenase (LDH) inhibitor (IC₅₀=40 nM). By inhibiting the activity of LDH, NCATS-SM1441 is able to reduce the production of lactic acid in cancer cells, helping to slow or stop the proliferation of cancer cells. NCATS-SM1441 can be used to study cancer metabolism.

商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。

NCATS-SM1441 構造式

CAS 番号 : 1964517-04-1

容量	価格（税別）	在庫状況	数量
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO ready for reconstitution	USD 974	在庫あり	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in DMSO	USD 974	在庫あり	Estimated Time of Arrival: December 31
Solid
5 mg	$700	在庫あり	Estimated Time of Arrival: December 31
10 mg	$1170	在庫あり	Estimated Time of Arrival: December 31
25 mg	$2340	在庫あり	Estimated Time of Arrival: December 31
50 mg	$3750	在庫あり	Estimated Time of Arrival: December 31
100 mg	$6000	在庫あり	Estimated Time of Arrival: December 31
200 mg		お問い合わせ
500 mg		お問い合わせ

or バルクお問い合わせ

* アイテムを追加する前、数量をご選択ください

This product is a controlled substance and not for sale in your territory.

おすすめ

•関連スクリーニングライブラリ:

•関連小分子:

•関連タンパク質:

生物活性
純度とドキュメンテーション
参考文献
カスタマーレビュー

製品説明

Cellular Effect

Cell Line	Type	Value	Description	References
A673	IC₅₀	105 nM Compound: 52; NACTS-SM1441	Cytotoxicity against human A673 cells assessed as reduction in cell viability after 48 hrs by CellTiter-Glo assay Cytotoxicity against human A673 cells assessed as reduction in cell viability after 48 hrs by CellTiter-Glo assay	[PMID: 32902275]
MIA PaCa-2	IC₅₀	347 nM Compound: 52; NACTS-SM1441	Cytotoxicity against human MIA PaCa-2 cells assessed as reduction in cell viability after 48 hrs by CellTiter-Glo assay Cytotoxicity against human MIA PaCa-2 cells assessed as reduction in cell viability after 48 hrs by CellTiter-Glo assay	[PMID: 32902275]

分子量

632.75

分子式

C₃₁H₂₅FN₄O₄S₃

CAS 番号

1964517-04-1

Appearance

Solid

Color

White to light yellow

SMILES

O=C(C1=CSC(N2N=C(C(CC3=CC=C(S(=O)(N)=O)C(F)=C3)=C2CC4CC4)C5=CC(C#CC6=CC=C(C)S6)=CC=C5)=N1)O

輸送条件

Room temperature in continental US; may vary elsewhere.

保管条件

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

溶剤 & 溶解度

体外:

DMSO : 100 mg/mL (158.04 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	1.5804 mL	7.9020 mL	15.8040 mL
5 mM	0.3161 mL	1.5804 mL	3.1608 mL
10 mM	0.1580 mL	0.7902 mL	1.5804 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

一般には略語で表示されます：C₁V₁ = C₂V₂

濃度 _（開始）

体積 _（開始）

濃度 _（終了）

体積 _（終了）

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

純度とドキュメンテーション

純度: 98.65%

Select Batch:

データシート (274 KB) SDS (251 KB)

COA (255 KB) HNMR (281 KB) RP-HPLC (258 KB) LCMS (112 KB)

取扱説明書 (2659 KB)

参考文献

[1]. Rai G, et al. Pyrazole-based lactate dehydrogenase inhibitors with optimized cell activity and pharmacokinetic properties[J]. Journal of medicinal chemistry, 2020, 63(19): 10984-11011. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	1.5804 mL	7.9020 mL	15.8040 mL	39.5101 mL
	5 mM	0.3161 mL	1.5804 mL	3.1608 mL	7.9020 mL
	10 mM	0.1580 mL	0.7902 mL	1.5804 mL	3.9510 mL
	15 mM	0.1054 mL	0.5268 mL	1.0536 mL	2.6340 mL
	20 mM	0.0790 mL	0.3951 mL	0.7902 mL	1.9755 mL
	25 mM	0.0632 mL	0.3161 mL	0.6322 mL	1.5804 mL
	30 mM	0.0527 mL	0.2634 mL	0.5268 mL	1.3170 mL
	40 mM	0.0395 mL	0.1976 mL	0.3951 mL	0.9878 mL
	50 mM	0.0316 mL	0.1580 mL	0.3161 mL	0.7902 mL
	60 mM	0.0263 mL	0.1317 mL	0.2634 mL	0.6585 mL
	80 mM	0.0198 mL	0.0988 mL	0.1976 mL	0.4939 mL
	100 mM	0.0158 mL	0.0790 mL	0.1580 mL	0.3951 mL

NCATS-SM1441 Related Classifications

Molarity Calculator
Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

質量		濃度		体積		分子量 *
	=		×		×

The dilution calculator equation

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

一般には略語で表示されます：C₁V₁ = C₂V₂

濃度 _（開始）	×	体積 _（開始）	=	濃度 _（終了）	×	体積 _（終了）
	×		=		×
C1		V1		C2		V2

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

NCATS-SM14411964517-04-1Lactate DehydrogenaseLDHInhibitorWarburg effectcancer cell metabolismlactate dehydrogenaseinhibitorinhibit

最近チェックした製品:

製品名

カスタマ需要量 *

お名前 *

タイトル

メールアドレス *

電話番号 *

デパートメント

組纖名 *

市区町村

都道府県

国或いは地域 *

必ず会社名を記載ください。個人への返信は行いません。

備考

製品名

Lot #