Nordoxepin-d4 hydrochloride
Based on 1 Customer Validation
Nordoxepin-d4 (Desmethyldoxepin-d4) hydrochloride is deuterium-labeled Nordoxepin (hydrochloride) (HY-100046).
For research use only. We do not sell to patients.
- Purity: 99.90%
- CAS No.: 2249819-14-3
- Formula: C18H16D4ClNO
- Molecular Weight:305.84
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Storage:
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Stable or radioisotope-labeled compounds allow precise tracking and quantification of individual atoms in metabolic pathways. Stable isotopes generally do not change molecular properties but may slightly affect metabolic kinetics; radioactive isotopes may interfere with cells. Markers can distinguish endogenous and exogenous metabolites, reduce false positives, and are beneficial to quantification and reconstruction of metabolic pathways[2].
In cell culture or enzymatic reactions, the use of isotope markers can precisely control the concentration and exposure time, making it easy to study metabolic reactions and enzyme activities. Through stable isotope analytical metabolomics (SIRM), cellular metabolic networks can be studied, key metabolic nodes and regulatory mechanisms can be identified, and targets can be provided for compound development.
Isotope-labeled compounds can be used in competition binding experiments to evaluate the affinity and binding kinetics of compounds to receptors to help optimize design. Stable isotope labels are used as internal standards in mass spectrometry analysis to improve analysis accuracy and reproducibility and reduce matrix effect interference[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Isotope labeling can reveal specific steps in metabolic pathways. Using compounds with stable isotope labels at specific locations directly in humans or animal models can also help verify drug mechanisms and evaluate unexpected side effects, improving the accuracy and efficiency of clinical research[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
1. This compound can be used as a tracer
2. This compound can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
Chemical Information
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CAS No. 2249819-14-3
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Unlabeled Cas 2887-91-4
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Appearance Solid
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Molecular Weight 305.84
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Formula C18H16D4ClNO
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Color White to off-white
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SMILES
CNC([2H])([2H])C([2H])([2H])/C=C1C2=CC=CC=C2OCC3=CC=CC=C/13.Cl
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Synonyms
Desmethyldoxepin-d4 hydrochloride
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Solvent & Solubility
DMSO : 30 mg/mL (98.09 mM; Need ultrasonic and warming; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (279 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [Content Brief]
[2]. Smith K A, et al. Soil and environmental analysis[M]. Marcel Dekker Incorporated, 2000.
[3]. Fan T W M, et al. Stable isotope-resolved metabolomics and applications for drug development[J]. Pharmacology & therapeutics, 2012, 133(3): 366-391. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 3.2697 mL | 16.3484 mL | 32.6968 mL | 81.7421 mL |
| 5 mM | 0.6539 mL | 3.2697 mL | 6.5394 mL | 16.3484 mL | |
| 10 mM | 0.3270 mL | 1.6348 mL | 3.2697 mL | 8.1742 mL | |
| 15 mM | 0.2180 mL | 1.0899 mL | 2.1798 mL | 5.4495 mL | |
| 20 mM | 0.1635 mL | 0.8174 mL | 1.6348 mL | 4.0871 mL | |
| 25 mM | 0.1308 mL | 0.6539 mL | 1.3079 mL | 3.2697 mL | |
| 30 mM | 0.1090 mL | 0.5449 mL | 1.0899 mL | 2.7247 mL | |
| 40 mM | 0.0817 mL | 0.4087 mL | 0.8174 mL | 2.0436 mL | |
| 50 mM | 0.0654 mL | 0.3270 mL | 0.6539 mL | 1.6348 mL | |
| 60 mM | 0.0545 mL | 0.2725 mL | 0.5449 mL | 1.3624 mL | |
| 80 mM | 0.0409 mL | 0.2044 mL | 0.4087 mL | 1.0218 mL |
Nordoxepin-d4 hydrochloride Related Classifications
HY-100046S1 Related Classifications
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