Pim-1 kinase inhibitor 4

Cat. No.: HY-149976: Ficha de datos Instrucciones de manejo
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Pim-1 kinase inhibitor 4 (Compound 10f) is a Pim-1 kinase inhibitor (IC₅₀: 17.01 nM). Pim-1 kinase inhibitor 4 also has antioxidant activity and inhibits DPPH. Pim-1 kinase inhibitor 4 induces apoptosis in PC-3 cell, and inhibits PC-3 cell growth with an IC₅₀ of 16 nM. Pim-1 kinase inhibitor 4 can be used for research of prostate cancer.

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Pim-1 kinase inhibitor 4 Estructura química

No. CAS : 3026670-71-0

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PIM1 PIM2 PIM3

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Descripciòn

Cellular Effect

Cell Line	Type	Value	Description	References
HepG2	IC₅₀	0.13 μM Compound: 10f	Cytotoxicity against human HepG2 cells assessed as inhibition of cell growth incubated for 48 hrs by MTT assay Cytotoxicity against human HepG2 cells assessed as inhibition of cell growth incubated for 48 hrs by MTT assay	[PMID: 36848846]
MCF7	IC₅₀	5.37 μM Compound: 10f	Cytotoxicity against human MCF7 cells assessed as inhibition of cell growth incubated for 48 hrs by MTT assay Cytotoxicity against human MCF7 cells assessed as inhibition of cell growth incubated for 48 hrs by MTT assay	[PMID: 36848846]
PC-3	IC₅₀	0.016 μM Compound: 10f	Cytotoxicity against human PC-3 cells assessed as inhibition of cell growth incubated for 48 hrs by MTT assay Cytotoxicity against human PC-3 cells assessed as inhibition of cell growth incubated for 48 hrs by MTT assay	[PMID: 36848846]

Peso molecular

333.77

Fòrmula

C₁₉H₁₂ClN₃O

No. CAS

3026670-71-0

SMILES

ClC1=CC(C2=NN=C(O2)C3=CC=NC(C4=CC=CC=C4)=C3)=CC=C1

Envío

Room temperature in continental US; may vary elsewhere.

Almacenamiento

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureza y Documentación

Instrucciones de manejo (2659 KB)

Referencias

[1]. Castanet AS, et al. Discovery of PIM-1 kinase inhibitors based on the 2,5-disubstituted 1,3,4-oxadiazole scaffold against prostate cancer: Design, synthesis, in vitro and in vivo cytotoxicity investigation. Eur J Med Chem. 2023 Mar 15;250:115220. [Content Brief]