Pomalidomide-C2-acid

Cat. No.: HY-150006 Purity: 99.78%: Data Sheet
COA

SDS
Handling Instructions
FAQs
Technical Support

Pomalidomide-C2-acid is a synthesized E3 ligase ligand-linker conjugate that incorporates the Pomalidomide based cereblon ligand and a linker used in PROTAC technology.

연구목적의 판매만을 진행합니다. 환자를 대상으로 한 판매는 하지 않습니다.

Pomalidomide-C2-acid 화학구조

CAS No. : 2225940-46-3

사이즈	재고	수량
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO ready for reconstitution	해외재고보유	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in DMSO	해외재고보유	Estimated Time of Arrival: December 31
Solid
50 mg	해외재고보유	Estimated Time of Arrival: December 31
100 mg	해외재고보유	Estimated Time of Arrival: December 31
250 mg	해외재고보유	Estimated Time of Arrival: December 31
500 mg	해외재고보유	Estimated Time of Arrival: December 31
1 g	해외재고보유	Estimated Time of Arrival: December 31
5 g	견적 받기
10 g	견적 받기

or 대량구매 문의

* 장바구니에 담기 전 물품의 수량을 선택해 주십시오.

This product is a controlled substance and not for sale in your territory.

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von Hippel-Lindau (VHL) MDM2 Cereblon cIAP1 Aryl Hydrocarbon Receptor TRIM21

Biological Activity
순도&문서
References
고객리뷰

제품 설명

Pomalidomide-C2-acid is a synthesized E3 ligase ligand-linker conjugate that incorporates the Pomalidomide based cereblon ligand and a linker used in PROTAC technology^[1].

IC₅₀ & Target^[1]

Cereblon

분자량

345.31

화학식

C₁₆H₁₅N₃O₆

CAS No.

2225940-46-3

Appearance

Solid

Color

Light yellow to yellow

SMILES

O=C(CCNC1=CC=CC(C(N2C3C(NC(CC3)=O)=O)=O)=C1C2=O)O

선적

Room temperature in continental US; may vary elsewhere.

보관

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

용액&용해도

In Vitro:

DMSO : 50 mg/mL (144.80 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.8959 mL	14.4797 mL	28.9595 mL
5 mM	0.5792 mL	2.8959 mL	5.7919 mL
10 mM	0.2896 mL	1.4480 mL	2.8959 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

몰농도 계산기
농도 희석 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

순도&문서

Purity: 99.78%

Select Batch:

Data Sheet (272 KB) SDS (418 KB)

COA (250 KB) HNMR (252 KB) LCMS (95 KB)

Handling Instructions (2659 KB)

References

[1]. Md Kabir, et al. Discovery and Characterization of a Novel Cereblon-Recruiting PRC1 Bridged PROTAC Degrader. J Med Chem. 2024 Apr 25;67(8):6880-6892. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	2.8959 mL	14.4797 mL	28.9595 mL	72.3987 mL
	5 mM	0.5792 mL	2.8959 mL	5.7919 mL	14.4797 mL
	10 mM	0.2896 mL	1.4480 mL	2.8959 mL	7.2399 mL
	15 mM	0.1931 mL	0.9653 mL	1.9306 mL	4.8266 mL
	20 mM	0.1448 mL	0.7240 mL	1.4480 mL	3.6199 mL
	25 mM	0.1158 mL	0.5792 mL	1.1584 mL	2.8959 mL
	30 mM	0.0965 mL	0.4827 mL	0.9653 mL	2.4133 mL
	40 mM	0.0724 mL	0.3620 mL	0.7240 mL	1.8100 mL
	50 mM	0.0579 mL	0.2896 mL	0.5792 mL	1.4480 mL
	60 mM	0.0483 mL	0.2413 mL	0.4827 mL	1.2066 mL
	80 mM	0.0362 mL	0.1810 mL	0.3620 mL	0.9050 mL
	100 mM	0.0290 mL	0.1448 mL	0.2896 mL	0.7240 mL