Procaterol hydrochloride hemihydrate
Based on 2 publication(s) in Google Scholar
Procaterol hydrochloride hemihydrate is an orally active β2 adrenoreceptor agonist. Procaterol hydrochloride hemihydrate can be used for the research of asthma.
For research use only. We do not sell to patients.
- Purity: 99.79%
- CAS No.: 81262-93-3
- Formula: C16H23ClN2O3.1/2H2O
- Molecular Weight:335.82
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Storage:
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Publications Citing Use of MedChemExpress (MCE) Procaterol hydrochloride hemihydrate
MoreAll Adrenergic Receptor Isoforms
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Biological Activity
Procaterol hydrochloride hemihydrate (0.1 μM, 24-72 h) decreases rhinovirus infection in human tracheal epithelial cells[4].
Procaterol hydrochloride hemihydrate (0-1 μg/mL, 24/48 h) inhibits IL-1β- and TNF-α-mediated eosinophil chemotactic activity in BEAS-2B cell[5].
procaterol hydrochloride hemihydrate (25-200 nM, 20 h) protects 16HBE cells from H2O2-induced oxidative stress[6].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Procaterol hydrochloride hemihydrate (0.1 mg/kg, i.p.) completely abolishes both the Mch-induced cough in conscious guinea pigs[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Allergic inflammatory guinea-pig model[2]
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Dosage:1, 3 or 10 μg/mL
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Administration:Inhaled administration
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Result:Inhibited histamine-induced airflow obstruction and microvascular leakage.
| NCT Number | Sponsor | Condition | Start Date |
Phase
|
|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
Chemical Information
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CAS No. 81262-93-3
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Appearance Solid
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Molecular Weight 335.82
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Formula C16H23ClN2O3.1/2H2O
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Color White to off-white
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SMILES
O[C@H]([C@H](NC(C)C)CC)C1=C(C=CC(N2)=O)C2=C(O)C=C1.Cl.[0.5 H2O]
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Synonyms
OPC 2009 hydrochloride hemihydrate
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Publications (2)
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Journal Impact Factor
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Most Recent
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Int J Biol Macromol
Reticuline isomerase AKR1B1 with aldo-keto reductase activity and detoxification function from the insect Blaps rhynchopetera. [Abstract]2026 Mar:352:151224. PMID: 41791543 -
J Pharm Biomed Anal
Screening method of mildronate and over 300 doping agents by reversed-phase liquid chromatography-high resolution mass spectrometry. [Abstract]2021 Feb 20:195:113870. PMID: 33453569
Solvent & Solubility
H2O : 25 mg/mL (74.44 mM; Need ultrasonic)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (281 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
References
[1]. Tukiainen H, et al. Comparison between oral procaterol and salbutamol in patients with bronchial asthma. Curr Med Res Opin. 1988;11(4):236-41. [Content Brief]
[2]. Mirza ZN, et al. Inhaled procaterol inhibits histamine-induced airflow obstruction and microvascular leakage in guinea-pig airways with allergic inflammation. Clin Exp Allergy. 1998 May;28(5):644-52. [Content Brief]
[3]. Ohkura N, et al. Bronchoconstriction-triggered cough in conscious guinea pigs. Exp Lung Res. 2009 May;35(4):296-306. [Content Brief]
[4]. Yamaya M, et al. Procaterol inhibits rhinovirus infection in primary cultures of human tracheal epithelial cells. Eur J Pharmacol. 2011 Jan 10;650(1):431-44. [Content Brief]
[5]. Koyama S, et al. Procaterol inhibits IL-1beta- and TNF-alpha-mediated epithelial cell eosinophil chemotactic activity. Eur Respir J. 1999 Oct;14(4):767-75. [Content Brief]
[6]. Deng Z, et al. Procaterol but not dexamethasone protects 16HBE cells from H₂O₂-induced oxidative stress. J Pharmacol Sci. 2014;125(1):39-50. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O | 1 mM | 2.9778 mL | 14.8889 mL | 29.7779 mL | 74.4446 mL |
| 5 mM | 0.5956 mL | 2.9778 mL | 5.9556 mL | 14.8889 mL | |
| 10 mM | 0.2978 mL | 1.4889 mL | 2.9778 mL | 7.4445 mL | |
| 15 mM | 0.1985 mL | 0.9926 mL | 1.9852 mL | 4.9630 mL | |
| 20 mM | 0.1489 mL | 0.7444 mL | 1.4889 mL | 3.7222 mL | |
| 25 mM | 0.1191 mL | 0.5956 mL | 1.1911 mL | 2.9778 mL | |
| 30 mM | 0.0993 mL | 0.4963 mL | 0.9926 mL | 2.4815 mL | |
| 40 mM | 0.0744 mL | 0.3722 mL | 0.7444 mL | 1.8611 mL | |
| 50 mM | 0.0596 mL | 0.2978 mL | 0.5956 mL | 1.4889 mL | |
| 60 mM | 0.0496 mL | 0.2481 mL | 0.4963 mL | 1.2407 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
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