country

Change Language

EN - English
FR - Français
DE - Deutsch
ES - Español
JA - 日本語
KO - 한국어

Product Name	Size / Unit Price	Qty

Total: USD 0.00 Checkout

Cat. No.: HY-181951

Copy Link Print Information

PROTAC BRD9 Degrader-11

PROTAC BRD9 Degrader-11 is a VHL-based BRD9 PROTAC degraderwith an IC₅₀ of 0.66 μM. PROTAC BRD9 Degrader-11 induces selective, proteasome-dependent degradation of BRD9 via the ubiquitin-proteasome system. PROTAC BRD9 Degrader-11 impairs cell viability, suppresses proliferation, and arrests growth of acute myeloid leukemia cells. PROTAC BRD9 Degrader-11 can be used for the research of acute myeloid leukemia.
(Pink: BRD9 ligand (HY-181952); Blue: VHL ligand (HY-125845); Black: linker).

For research use only. We do not sell to patients.

Formula: C₅₂H₆₆N₁₀O₇S
Molecular Weight:975.21

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (267 KB)

PROTAC BRD9 Degrader-11 Chemical Structure

Size

Price

Stock

Quantity

Amount: USD 0.00

* Please select Quantity before adding items.

Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Bioz

Biological Activity

Description

PROTAC BRD9 Degrader-11 is a VHL-based BRD9 PROTAC degraderwith an IC₅₀ of 0.66 μM. PROTAC BRD9 Degrader-11 induces selective, proteasome-dependent degradation of BRD9 via the ubiquitin-proteasome system. PROTAC BRD9 Degrader-11 impairs cell viability, suppresses proliferation, and arrests growth of acute myeloid leukemia cells. PROTAC BRD9 Degrader-11 can be used for the research of acute myeloid leukemia^[1]. (Pink: BRD9 ligand (HY-181952); Blue: VHL ligand (HY-125845); Black: linker).

IC₅₀ & Target^[1]

VHL

BRD9

All PROTACs Isoforms :

All Epigenetic Reader Domain Isoforms :

In Vitro

PROTAC BRD9 Degrader-11 (Compound 9) binds to BRD9 with an IC₅₀ of 0.66 ± 0.04 μM, demonstrating high target affinity^[1].
PROTAC BRD9 Degrader-11 (1-25 μM; 48 h) selectively degrades BRD9 in U937 cells in a dose-dependent manner via the proteasome pathway, with maximal degradation at 25 μM over 48 hours^[1].
PROTAC BRD9 Degrader-11 (1-25 μM; 24-48 h) potently inhibits the proliferation of U937 cells and reduces viability, with stronger activity at the 48-hour time point^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis^[1]

Cell Line:

Human pro-monocytic acute myeloid leukemia U937 cells
Concentration:

1, 5, 10, 25 μM; 25 μM MG132 (final 6 h for mechanism validation)
Incubation Time:

48 h; 6 h (MG132 co-treatment)
Result:

Induced dose-dependent degradation of BRD9.
Did not alter BRD7 protein levels.
Rescued BRD9 depletion when co-treated with MG132, confirming proteasome-dependent degradation.

Chemical Information

Molecular Weight 975.21
Formula C₅₂H₆₆N₁₀O₇S
SMILES

O=C(NC1=CC=CC(NC2=NC3=CC=CC=C3N4C2=NN=C4CCCC)=C1)CCCCCCOCCOCC(N[C@@H](C(C)(C)C)C(N5[C@H](C(NCC6=CC=C(C7=C(C)N=CS7)C=C6)=O)C[C@@H](O)C5)=O)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (267 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Pierri M, et al. Unveiling New Triazoloquinoxaline-Based PROTACs Designed for the Selective Degradation of the ncBAF Chromatin Remodeling Subunit BRD9. Chemistry. 2025;31(34):e202404218. [Content Brief]

Calculators

Molarity Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Dilution Calculator

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

Get Quote In-stock

Amount: USD 0.00

Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Purity & Documentation
References

Product Name:
Cat. No.:
Quantity:
MCE Japan Authorized Agent:

Product Name:
CAS No.:
Species:
Purity:
Quantity:

PROTAC BRD9 Degrader-11

All PROTACs Isoforms

All Epigenetic Reader Domain Isoforms