Purine nucleoside phosphorylase, Microorganism
Based on 1 Customer Validation
Purine nucleoside phosphorylase, Microorganism (PNP) is a key enzyme in purine metabolism, which is involved in the purine rescue pathway. The deficiency of Purine nucleoside phosphorylase resulted in impaired T cell function. In the presence of inorganic orthophosphate as the second substrate, Purine nucleoside phosphorylase catalyzes the breaking of the glycosidic bond between ribose and deoxyribonucleoside to generate purine base and ribose (deoxyribose) -1-phosphate.
For research use only. We do not sell to patients.
- CAS No.: 9030-21-1
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
All Endogenous Metabolite Isoforms
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Biological Activity
Description
In Vitro
Product Information
Molecular weight: about 100 kDa, trimer
pH stability: 6.0-9.0, optimum pH 6.5-8.0
Inhibitors: p-Chloromercuric benzoic acid, SDS, Hg2+, Ag+
Instructions
Soluble in water (below 100 mg/mL concentration), or dissolved in buffer according to specific experimental references.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Clinical Trial
| NCT Number | Sponsor | Condition | Start Date |
Phase
|
|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
EC Number
2.4.2.1
Enzyme Activity
≥10 U/mg soild
Unit Definition
One unit is defined as the amount of enzyme that will cause the phosphorolysis of 1μ mol of inosine to hypoxanthine and ribose 1-phosphate per min at pH 7.7 at 37°C.
Chemical Information
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CAS No. 9030-21-1
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Appearance Solid
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Color White to off-white
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SMILES
[Purine nucleoside phosphorylase, Microorganism]
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Synonyms
PNP
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Solvent & Solubility
In Vitro:
H2O : ≥ 100 mg/mL
* "≥" means soluble, but saturation unknown.
Purity & Documentation
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Data Sheet (263 KB)
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SDS (418 KB)
- English - EN (418 KB)
- Français - FR (418 KB)
- Deutsch - DE (418 KB)
- Norwegian - NO (418 KB)
- Español - ES (418 KB)
- Swedish - SV (418 KB)
- Italian - IT (418 KB)
- Korean - KR (418 KB)
- Portuguese - PT (418 KB)
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Handling Instructions (2659 KB)
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purine nucleoside phosphorylase, Microorganism Related Classifications
HY-P2724 Related Classifications
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