Annexin A13/ANXA13 Protein, Human
Based on 1 Customer Validation
Annexin A13 Protein, Human is a 35-kDa multifunctional protein which belongs to the annexin family. Annexin A13 is highly expressed in the digestive system and may plays a role in apoptotic cell-mediated immunosuppression, hypertension, and cell death recognition. Annexin A13 can be used as biomarker in CRC biomarker in colorectal cancer (CRC).
- Species: Human
- Source: E. coli
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Storage:Stored at -80°C for 1 year from date of receipt. It is stable at -20°C for 3 months after opening. It is recommended to freeze aliquots at -80°C for extended storage. Avoid repeated freeze-thaw cycles.
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Biological Activity
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Technical Parameters
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Product Properties
- Documentation
- References
- Help & FAQs
Biological Activity
Description
Annexin A13 Protein, Human is a 35-kDa multifunctional protein which belongs to the annexin family. Annexin A13 is highly expressed in the digestive system and may plays a role in apoptotic cell-mediated immunosuppression, hypertension, and cell death recognition. Annexin A13 can be used as biomarker in CRC biomarker in colorectal cancer (CRC)[1].
Background
The Annexins comprise a family of proteins that are involved in many aspects of cellular membrane dynamics and the regulation of membrane-associated proteins.ANX A13 is a calcium-dependent phospholipid-binding protein being preferentially located on the cytosolic face of the plasma membrane. Annexin A13 plays a role in cytoskeletal interactions, phospholipase inhibition, regulation of cellular growth, and intracellular signal transduction pathways. Human Annexin A13 shares approximately 86% and 91% aa sequence identity with mouse and dog Annexin A13.
MCE Validation Data
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Purity - SDS-PAGE
Purity - SDS-PAGE
Technical Parameters
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Species Human
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Source E. coli
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Tag Tag Free
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Accession
P27216 (G2-H316)
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Molecular Construction
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N-term
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ANXA13 (G2-H316)
Accession # P27216 -
C-term
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Protein Length
Full Length
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Synonyms
ANXA13; Annexin-13; Prev. ANX13; Annexin, Intestine-Specific; Intestine-Specific Annexin; Annexin; Annexin XIII; Annexin A13; ISA
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AA Sequence
GNRHAKASSPQGFDVDRDAKKLNKACKGMGTNEAAIIEILSGRTSDERQQIKQKYKATYGKELEEVLKSELSGNFEKTALALLDRPSEYAARQLQKAMKGLGTDESVLIEVLCTRTNKEIIAIKEAYQRLFDRSLESDVKGDTSGNLKKILVSLLQANRNEGDDVDKDLAGQDAKDLYDAGEGRWGTDELAFNEVLAKRSYKQLRATFQAYQILIGKDIEEAIEEETSGDLQKAYLTLVRCAQDCEDYFAERLYKSMKGAGTDEETLIRIVVTRAEVDLQGIKAKFQEKYQKSLSDMVRSDTSGDFRKLLVALLH
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Predicted Molecular Mass
35.4 kDa
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Molecular Weight
Approximately 33 kDa, based on SDS-PAGE under reducing conditions.
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Purity
≥ 95%, as determined by reducing SDS-PAGE.
Product Properties
Solution
Supplied as a 0.22 μm filtered solution of 20 mM Tris-HCl, 100 mM NaCl, 10% glycerol, pH 8.0.
Note: For SPR assay, please replace the buffer. Primary amine components (e.g., Tris, imidazole) can affect protein-coupled chips.
<1 EU/μg, determined by LAL method.
Stored at -80°C for 1 year from date of receipt. It is stable at -20°C for 3 months after opening. It is recommended to freeze aliquots at -80°C for extended storage. Avoid repeated freeze-thaw cycles.
Shipping with dry ice.
Documentation
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Data Sheet (262 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Handling Instructions (2659 KB)
References
[1]. Guozhong Jiang, et al. Annexin A13 promotes tumor cell invasion in vitro and is associated with metastasis in human colorectal cancer. Oncotarget. 2017 Mar 28;8(13):21663-21673. [Content Brief]
[2]. Volker Gerke, et al. Annexins: from structure to function.Physiol Rev. 2002 Apr;82(2):331-71. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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