C-MPL Protein, Human (HEK293, His)

C-MPL Protein, the thrombopoietin receptor, is a pivotal regulator of megakaryopoiesis and platelet production, suggesting a specific role in TPO-R-dependent immune responses. Forming homodimers and interacting with ATXN2L, it contributes to its multifaceted role in hematopoiesis and immune modulation. C-MPL Protein, Human (HEK293, His) is the recombinant human-derived C-MPL protein, expressed by HEK293 , with C-His labeled tag. The total length of C-MPL Protein, Human (HEK293, His) is 466 a.a., with molecular weight of 68-70 kDa.

C-MPL Protein serves as the receptor for thrombopoietin, playing a pivotal role as a primary regulator of megakaryopoiesis and platelet production. Its involvement suggests a potential regulatory function specific to TPO-R-dependent immune responses. The protein forms homodimers and interacts with ATXN2L, contributing to its multifaceted role in hematopoiesis and immune modulation.

Measured by its binding ability in a functional ELISA. When immobilized Human c-MPL, His Tag at 0.2 μg/mL, can bind Anti-c-MPL Antibody, hFc Tag with the EC₅₀ of 14.3 ng/mL.

Human

HEK293

C-His

P40238 (Q26-W491)

4352  [NCBI]

68-70 kDa

Greater than 95% as determined by Tris-Bis PAGE.

Lyophilized powder.

Lyophilized from a 0.22 μm filtered solution of PBS, pH 7.4. Normally 8% trehalose is added as protectant before lyophilization.

<1 EU/μg, determined by LAL method.

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH₂O.

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US; may vary elsewhere.