CD24 Protein, Mouse (HEK293, His)
The CD24 protein may coordinate cellular differentiation of various cell types, particularly in early thymocyte development. Activation of its signaling involves binding of a lectin-like ligand to the CD24 carbohydrate, triggering the release of second messengers from GPI anchors. CD24 Protein, Mouse (HEK293, His) is the recombinant mouse-derived CD24 protein, expressed by HEK293, with C-His labeled tag.
- Species: Mouse
- Source: HEK293
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Storage:Stored at -20°C for 2 years from date of receipt. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.
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Biological Activity
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Technical Parameters
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Product Properties
- Documentation
- Help & FAQs
Biological Activity
Description
The CD24 protein may coordinate cellular differentiation of various cell types, particularly in early thymocyte development. Activation of its signaling involves binding of a lectin-like ligand to the CD24 carbohydrate, triggering the release of second messengers from GPI anchors. CD24 Protein, Mouse (HEK293, His) is the recombinant mouse-derived CD24 protein, expressed by HEK293, with C-His labeled tag.
Background
CD24 Protein is postulated to play a pivotal role in the cell differentiation processes of various cell types, with a specific implication in early thymocyte development. Its signaling potential is suggested to be triggered by the binding of a lectin-like ligand to the CD24 carbohydrates, transduced through the release of second messengers derived from the GPI-anchor. Additionally, CD24 is implicated in modulating B-cell activation responses, indicative of its regulatory influence in immune processes. In conjunction with SIGLEC10, CD24 may participate in the selective suppression of the immune response to danger-associated molecular patterns (DAMPs) such as HMGB1, HSP70, and HSP90. This CD24:SIGLEC10 complex is proposed to inhibit HMGB1-mediated tissue damage immune responses, suggesting CD24's role in immune regulation and control of autoimmunity. The multifaceted functions of CD24 underscore its potential as a key player in diverse cellular and immune processes.
Technical Parameters
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Species Mouse
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Source HEK293
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Tag C-His
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Accession
P24807 (N27-G53)
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Gene ID12484
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Molecular Construction
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N-term
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CD24 (N27-G53)
Accession # P24807 -
His
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C-term
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Protein Length
Full Length of Mature Protein
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Synonyms
CD24; Signal Transducer CD24; CD24 Molecule; Small Cell Lung Carcinoma Cluster 4 Antigen; CD24A; CD24 Antigen; CD24 Antigen (Small Cell Lung Carcinoma Cluster 4 Antigen)
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AA Sequence
NQTSVAPFPGNQNISASPNPSNATTRG
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Predicted Molecular Mass
4.6 kDa
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Molecular Weight
Approximately 20-40 kDa, based on SDS-PAGE under reducing conditions, due to the glycosylation.
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Glycosylation
Yes
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Purity
≥ 90%, as determined by reducing SDS-PAGE.
Product Properties
Lyophilized powder.
<1 EU/μg, determined by LAL method.
It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH2O. For long term storage it is recommended to add a carrier protein (0.1% BSA, 5% HSA, 10% FBS or 5% Trehalose).
Stored at -20°C for 2 years from date of receipt. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.
Room temperature in continental US; may vary elsewhere.
Documentation
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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