CDK14 Protein, Human (sf9, GST)
CDK14 Protein, Human (sf9, GST) is the recombinant human-derived CDK14, expressed by Sf9 insect cells , with GST labeled tag.
- Species: Human
- Source: Sf9 insect cells
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Storage:Stored at -80°C for 1 year from date of receipt. It is stable at -20°C for 3 months after opening. It is recommended to freeze aliquots at -80°C for extended storage. Avoid repeated freeze-thaw cycles.
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Biological Activity
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Technical Parameters
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Product Properties
- Documentation
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Biological Activity
Description
CDK14 Protein, Human (sf9, GST) is the recombinant human-derived CDK14, expressed by Sf9 insect cells , with GST labeled tag.
Background
CDK14 is a serine/threonine-protein kinase involved in eukaryotic cell cycle control, with activity regulated by associated cyclins. During G2/M phase, it modulates the Wnt signaling pathway by phosphorylating LRP6 at 'Ser-1490' to activate the pathway. Through interaction with CCDN3, CDK14 regulates cell cycle progression and proliferation. In vitro studies demonstrate its ability to phosphorylate RB1, though in vivo relevance requires further validation. Potential roles in meiosis, neuronal differentiation, and indirect negative regulation of insulin-responsive glucose transport are suggested. by similar: Functional overlaps exist with other CDK family members (e.g., CDK1/cyclin B) in cell cycle regulation mechanisms.
Technical Parameters
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Species Human
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Source Sf9 insect cells
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Tag GST
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Accession
O94921-1 (M1-H469)
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Gene ID5218
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Protein Length
Full Length of Isoform-1
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Synonyms
CDK14; PFTAIRE1; Prev. PFTK1; PFTAIRE Protein Kinase 1; Cell Division Protein Kinase 14; HPFTAIRE1; Cyclin-Dependent Kinase 14; KIAA0834; Cyclin Dependent Kinase 14; Serine/Threonine-Protein Kinase PFTAIRE-1
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AA Sequence
MCDLIEPQPAEKIGKMKKLRRTLSESFSRIALKKDDTTFDEICVTKMSTRNCQGMDSVIKPLDTIPEDKKVRVQRTQSTFDPFEKPANQVKRVHSENNACINFKTSSTGKESPKVRRHSSPSSPTSPKFGKADSYEKLEKLGEGSYATVYKGKSKVNGKLVALKVIRLQEEEGTPFTAIREASLLKGLKHANIVLLHDIIHTKETLTLVFEYVHTDLCQYMDKHPGGLHPDNVKLFLFQLLRGLSYIHQRYILHRDLKPQNLLISDTGELKLADFGLARAKSVPSHTYSNEVVTLWYRPPDVLLGSTEYSTCLDMWGVGCIFVEMIQGVAAFPGMKDIQDQLERIFLVLGTPNEDTWPGVHSLPHFKPERFTLYSSKNLRQAWNKLSYVNHAEDLASKLLQCSPKNRLSAQAALSHEYFSDLPPRLWELTDMSSIFTVPNVRLQPEAGESMRAFGKNNSYGKSLSNSKH
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Molecular Weight
Approximately 72 kDa, based on SDS-PAGE under reducing conditions.
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Purity
≥ 95%, as determined by reducing SDS-PAGE.
Product Properties
Solution.
Please use rapid thawing with running water to thaw the protein.
Stored at -80°C for 1 year from date of receipt. It is stable at -20°C for 3 months after opening. It is recommended to freeze aliquots at -80°C for extended storage. Avoid repeated freeze-thaw cycles.
Shipping with dry ice.
Documentation
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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