CDK14/PFTK1
CDK14, originally named PFTK1, forms an unusual complex with the palmitoylated cyclin Y, which tethers the kinase to the plasma membrane and controls its activation cycle. At the membrane, cyclin Y-CDK14 phosphorylates the Wnt co-receptor LRP6 on its Ser1490-cluster motif, a priming step required for canonical Wnt signaling. CDK14 also contributes to transcriptional regulation and to proliferation in various cancers, where it is frequently overexpressed. Among the CDK family, CDK14 and its paralog CDK15 are set apart by their cyclin Y dependence rather than cyclin D-type pairing, placing them functionally between cell-cycle CDKs and transcriptional CDK12/13.
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CDK14/PFTK1 Recombinant Proteins (2)
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Recombinant Protein Expression Service
- Codon Optimization
- Gene Synthesis
- Construction of Expression Vector
- Strain Screening
- Protein Expression
- Purification & QC
- Protein Delivery
- Formula: Human
- Molecular Weight: Sf9 insect cells
The EpCAM/TROP1 protein serves as an important homogeneous interacting molecule that promotes direct contact between intestinal epithelial cells (IEC) and intraepithelial lymphocytes (IEL) in the mucosal epithelium. This feature helps establish an immune barrier against mucosal infections. EpCAM/TROP1 Protein, Human (His-SUMO) is the recombinant human-derived EpCAM/TROP1 protein, expressed by E. coli , with N-6*His, N-SUMO labeled tag.
