FGF-1 Protein, Cynomolgus

Fibroblast growth factor 1 is a growth factor and signaling protein encoded by the FGF1 gene. FGF-1 is a ligand of FGFR1 and integrin, and plays an important role in cell survival, division, angiogenesis, differentiation, and migration. FGF-1 induces the phosphorylation and activation of FGFR1, FRS2, MAPK3/ERK1, MAPK1/ERK2, and AKT1, and also stimulates angiogenesis. FGF-1 Protein, Cynomolgus is the recombinant cynomolgus-derived FGF-1 protein, expressed by E. coli , with tag free. The total length of FGF-1 Protein, Cynomolgus is 140 a.a., with molecular weight of ~16 KDa.

Fibroblast growth factor 1 is a growth factor and signaling protein encoded by the FGF1 gene. FGF-1 protein plays a critical role in the regulation of a variety of cellular processes, including cell survival, division, angiogenesis, differentiation, and migration. It acts as a potent mitogen and as a ligand for FGFR1 and integrin. In the presence of heparin, FGF-1 binds to FGFR1, leading to dimerization and activation through autophosphorylation of tyrosine residues. FGF-1 also binds to the integrin ITGAV: ITGB3, forms a ternary complex with FGFR1 and induces PTPN11 recruitment to the complex. It induces the phosphorylation and activation of FGFR1, FRS2, MAPK3/ERK1, MAPK1/ERK2, and AKT1, and can also stimulate angiogenesis. FGF-1 interacts with a variety of receptors and proteins, including FGFR2, FGFR3, FGFR4, FGFBP1, S100A13, SYT1, LRRC59, CSNKA, CSNKB and FIBP^[1][2][3].

Cynomolgus

E. coli

Tag Free

NP_001252958 (F16-D155)

705970  [NCBI]

Approximately 16 kDa.

Greater than 95% as determined by reducing SDS-PAGE

<1 EU/μg, determined by LAL method.