LRRTM4 Protein, Human (HEK293, His)
The LRRTM4 protein plays a critical role in the development and maintenance of the vertebrate nervous system, particularly in synaptogenesis and differentiation of excitatory presynaptic elements. LRRTM4 is associated with the AMPA receptor (AMPAR) complex, is located at the periphery of the complex, interacts directly with GluA/GRIA proteins, and helps coordinate the complex network of AMPAR complex assembly and function. LRRTM4 Protein, Human (HEK293, His) is the recombinant human-derived LRRTM4 protein, expressed by HEK293 , with C-His labeled tag.
- Species: Human
- Source: HEK293
-
Storage:Stored at -20°C for 2 years from date of receipt. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Biological Activity
-
Technical Parameters
-
Product Properties
- Documentation
- Help & FAQs
Biological Activity
Description
The LRRTM4 protein plays a critical role in the development and maintenance of the vertebrate nervous system, particularly in synaptogenesis and differentiation of excitatory presynaptic elements. LRRTM4 is associated with the AMPA receptor (AMPAR) complex, is located at the periphery of the complex, interacts directly with GluA/GRIA proteins, and helps coordinate the complex network of AMPAR complex assembly and function. LRRTM4 Protein, Human (HEK293, His) is the recombinant human-derived LRRTM4 protein, expressed by HEK293 , with C-His labeled tag.
Background
LRRTM4 protein emerges as a key player in the development and maintenance of the vertebrate nervous system, with a particularly pronounced role in synaptogenesis, specifically influencing excitatory presynaptic differentiation. Functionally associated with the AMPA receptor (AMPAR) complex, LRRTM4 is positioned peripherally within this complex, which consists of an inner core comprising four pore-forming GluA/GRIA proteins and four major auxiliary subunits. LRRTM4 is part of the outer core, interacting directly with GluA/GRIA proteins, and contributes to the intricate network of proteins orchestrating AMPAR complex assembly and function. Understanding LRRTM4's role in the context of excitatory neurotransmission and the regulation of AMPAR complex dynamics holds promise for unraveling the complexities of synaptic connectivity in the nervous system. Further investigation is needed to elucidate the specific mechanisms by which LRRTM4 influences excitatory presynaptic differentiation and contributes to overall neural network development.
Technical Parameters
-
Species Human
-
Source HEK293
-
Tag C-His
-
Accession
Q86VH4-1 (Q31-K424)
-
Molecular Construction
-
N-term
-
LRRTM4 (Q31-K424)
Accession # Q86VH4-1 -
His
-
C-term
-
-
Protein Length
Extracellular Domain
-
Synonyms
LRRTM4; FLJ12568; Leucine Rich Repeat Transmembrane Neuronal 4; CDNA FLJ12568 Fis, Clone NT2RM4000857, Weakly Similar To LEUCINE-RICH ALPHA-2-GLYCOPROTEIN; Leucine-Rich Repeat Transmembrane Neuronal Protein 4; LRRTM4 Protein
-
AA Sequence
QRACPKNCRCDGKIVYCESHAFADIPENISGGSQGLSLRFNSIQKLKSNQFAGLNQLIWLYLDHNYISSVDEDAFQGIRRLKELILSSNKITYLHNKTFHPVPNLRNLDLSYNKLQTLQSEQFKGLRKLIILHLRSNSLKTVPIRVFQDCRNLDFLDLGYNRLRSLSRNAFAGLLKLKELHLEHNQFSKINFAHFPRLFNLRSIYLQWNRIRSISQGLTWTWSSLHNLDLSGNDIQGIEPGTFKCLPNLQKLNLDSNKLTNISQETVNAWISLISITLSGNMWECSRSICPLFYWLKNFKGNKESTMICAGPKHIQGEKVSDAVETYNICSEVQVVNTERSHLVPQTPQKPLIIPRPTIFKPDVTQSTFETPSPSPGFQIPGAEQEYEHVSFHK
-
Predicted Molecular Mass
46.6 kDa
-
Molecular Weight
Approximately 65 kDa, based on SDS-PAGE under reducing conditions, due to the glycosylation.
-
Glycosylation
Yes
-
Purity
≥ 95%, as determined by reducing SDS-PAGE.
Product Properties
Lyophilized powder.
<1 EU/μg, determined by LAL method.
It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH2O. For long term storage it is recommended to add a carrier protein (0.1% BSA, 5% HSA, 10% FBS or 5% Trehalose).
Stored at -20°C for 2 years from date of receipt. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.
Room temperature in continental US; may vary elsewhere.
Documentation
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Powered by Bioz
