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LRRTM4 Protein, Human (HEK293, His)

Cat. No.: HY-P76481
Handling Instructions

The LRRTM4 protein plays a critical role in the development and maintenance of the vertebrate nervous system, particularly in synaptogenesis and differentiation of excitatory presynaptic elements. LRRTM4 is associated with the AMPA receptor (AMPAR) complex, is located at the periphery of the complex, interacts directly with GluA/GRIA proteins, and helps coordinate the complex network of AMPAR complex assembly and function. LRRTM4 Protein, Human (HEK293, His) is the recombinant human-derived LRRTM4 protein, expressed by HEK293 , with C-His labeled tag. The total length of LRRTM4 Protein, Human (HEK293, His) is 394 a.a., with molecular weight of ~65 KDa.

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Description

The LRRTM4 protein plays a critical role in the development and maintenance of the vertebrate nervous system, particularly in synaptogenesis and differentiation of excitatory presynaptic elements. LRRTM4 is associated with the AMPA receptor (AMPAR) complex, is located at the periphery of the complex, interacts directly with GluA/GRIA proteins, and helps coordinate the complex network of AMPAR complex assembly and function. LRRTM4 Protein, Human (HEK293, His) is the recombinant human-derived LRRTM4 protein, expressed by HEK293 , with C-His labeled tag. The total length of LRRTM4 Protein, Human (HEK293, His) is 394 a.a., with molecular weight of ~65 KDa.

Background

LRRTM4 protein emerges as a key player in the development and maintenance of the vertebrate nervous system, with a particularly pronounced role in synaptogenesis, specifically influencing excitatory presynaptic differentiation. Functionally associated with the AMPA receptor (AMPAR) complex, LRRTM4 is positioned peripherally within this complex, which consists of an inner core comprising four pore-forming GluA/GRIA proteins and four major auxiliary subunits. LRRTM4 is part of the outer core, interacting directly with GluA/GRIA proteins, and contributes to the intricate network of proteins orchestrating AMPAR complex assembly and function. Understanding LRRTM4's role in the context of excitatory neurotransmission and the regulation of AMPAR complex dynamics holds promise for unraveling the complexities of synaptic connectivity in the nervous system. Further investigation is needed to elucidate the specific mechanisms by which LRRTM4 influences excitatory presynaptic differentiation and contributes to overall neural network development.

Species

Human

Source

HEK293

Tag

C-His

Accession

Q86VH4 (Q31-K424)

Gene ID
Molecular Construction
N-term
LRRTM4 (Q31-K424)
Accession # Q86VH4
His
C-term
Synonyms
Leucine-rich repeat transmembrane neuronal protein 4
Molecular Weight

Approximately 65 kDa.

Purity

Greater than 95% as determined by reducing SDS-PAGE

Endotoxin Level

<1 EU/μg, determined by LAL method.

Documentation

LRRTM4 Protein, Human (HEK293, His) Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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The specific activity calculator equation

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)
Unit/mg = 106 ÷ ng/mL

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LRRTM4 Protein, Human (HEK293, His)
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HY-P76481
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