2. Gene
  3. LRRTM4 - leucine rich repeat transmembrane neuronal 4 Gene

LRRTM4 - leucine rich repeat transmembrane neuronal 4 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens
Gene ID: 80059 | Gene type: protein coding

About LRRTM4

Cytogenetic location: 2p12 Genomic coordinates (GRCh38): 2:76,747,685-77,522,376 (from NCBI)

This gene has 7 transcripts (splice variants), 420 orthologues and 22 paralogues. Biased expression in brain (RPKM 5.6) and lung (RPKM 0.2).

Summary

Predicted to enable heparan sulfate proteoglycan binding activity. Predicted to be involved in regulation of synapse assembly. Predicted to act upstream of or within AMPA glutamate receptor clustering; positive regulation of synapse assembly; and regulation of presynaptic membrane organization. Predicted to be located in postsynaptic membrane. Predicted to be part of AMPA glutamate receptor complex. Predicted to be active in extracellular matrix; extracellular space; and glutamatergic synapse. Predicted to be integral component of postsynaptic density membrane. [provided by Alliance of Genome Resources, Apr 2022]

LRRTM4 Products(5)

mRNA Protein Name
NM_001134745.3 NP_001128217.1 leucine-rich repeat transmembrane neuronal protein 4 isoform a precursor
NM_001282924.3 NP_001269853.1 leucine-rich repeat transmembrane neuronal protein 4 isoform a precursor
NM_001282928.3 NP_001269857.1 leucine-rich repeat transmembrane neuronal protein 4 isoform c precursor
NM_001330370.2 NP_001317299.1 leucine-rich repeat transmembrane neuronal protein 4 isoform d precursor
NM_024993.6 NP_079269.4 leucine-rich repeat transmembrane neuronal protein 4 isoform b precursor

LRRTM4 Protein Structure

LRR_8

LRR_8: Leucine rich repeat (66 - 121)

LRR_1

LRR_1: Leucine Rich Repeat (134 - 156)

LRR_8

LRR_8: Leucine rich repeat (159 - 216)

LRR_8

LRR_8: Leucine rich repeat (230 - 289)

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  • 590 a.a.
Protein Preferred Names Protein Names

leucine-rich repeat transmembrane neuronal protein 4

Recombinant LRRTM4 Proteins

Cat. No. Product Name Accession Purity
HY-P76481 LRRTM4 Protein, Human (HEK293, His) Q86VH4 (Q31-K424) ≥95%

Related Diseases

Diseases Alias
Schizophrenia 18

SCZD18

Schizophrenia 18 With Or Without An Affective Disorder

Schizophrenia Susceptibility 18

Chromosome 7q36.3 Duplication Syndrome, 362-Kb

Schizophrenia, Type 18
Epilepsy, Familial Temporal Lobe, 5

Familial Temporal Lobe Epilepsy 5

ETL5

Epilepsy, Temporal Lobe, Familial, Type 5
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS07844 LRRTM4 Human Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta LRRTM4 VGNC VGNC:106180
Canis familiaris LRRTM4 VGNC VGNC:42832
Mus musculus LRRTM4 MGD MGI:2389180
Bos taurus LRRTM4 VGNC VGNC:59345
Rattus norvegicus LRRTM4 RGD RGD:1560707
Felis catus LRRTM4 VGNC VGNC:63317
Others LRRTM4 NCBI