1. Recombinant Proteins
  2. Cytokines and Growth Factors
  3. Chemokine & Receptors
  4. CC Chemokines
  5. CCL23
  6. MPIF-1/CCL23 Protein, Human (99a.a, CHO)

MPIF-1/CCL23 Protein, Human (99a.a, CHO)

Cat. No.: HY-P7259
Handling Instructions

MPIF-1/CCL23 Protein, Human (99a.a, CHO) is a CC chemokine, induces endothelial cell migration and tube formation via CCR1.

For research use only. We do not sell to patients.

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Top Publications Citing Use of Products
  • Biological Activity

  • Technical Parameters

  • Properties

  • Documentation

  • References

Description

MPIF-1/CCL23 Protein, Human (99a.a, CHO) is a CC chemokine, induces endothelial cell migration and tube formation via CCR1.

Background

Human CCL23 (also known as CKb8, MPIF-1, or MIP-3) is a CC chemokine, which induces endothelial cell migration and tube formation via CCR1. CCL23 also exhibits chemotactic activity on monocytes and dendritic cells, and inhibits the formation of bone marrow-derived colony-forming cells[1].

Biological Activity
The ED50 is <2 μg/mL as measured by CHO-K1/Gα15/hCCR1 cells (human Gα15 and human CCR1 stably expressed in CHO-K1 cells).
Species

Human

Source

CHO

Tag

Tag Free

Accession

P55773 (R22-N120)

Gene ID

6368  [NCBI]

Synonyms
rHuMIP-3/CCL23; C-C motif chemokine 23; MPIF-1; SCYA23
AA Sequence

RVTKDAETEFMMSKLPLENPVLLDRFHATSADCCISYTPRSIPCSLLESYFETNSECSKPGVIFLTKKGRRFCANPSDKQVQVCVRMLKLDTRIKTRKN

Molecular Weight

Approximately 12 kDa

Appearance

Lyophilized powder.

Formulation

Lyophilized after extensive dialysis against PBS.

Endotoxin Level

<0.2 EU/μg, determined by LAL method.

Reconstitution

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH2O or PBS.

Storage & Stability

Stored at -20°C. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer. It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Shipping

Room temperature in continental US; may vary elsewhere.

Documentation
References

MPIF-1/CCL23 Protein, Human (99a.a, CHO) Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

  • Reconstitution Calculator

  • Dilution Calculator

  • Specific Active Calculator

The reconstitution calculator equation

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration
= ÷

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

The specific active calculator equation

Specific Active (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Active (Unit/mg) = 106 ÷ Biological Activity (ED50)
Unit/mg = 106 ÷ ng/mL

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Product Name:
MPIF-1/CCL23 Protein, Human (99a.a, CHO)
Cat. No.:
HY-P7259
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