TEAD2 Protein, Human (Depalmitoylated, sf9)
TEAD2 Protein, Human (Depalmitoylated, sf9) is the recombinant human-derived TEAD2 protein, expressed by Sf9 insect cells, with tag free tag.
- Species: Human
- Source: Sf9 insect cells
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Storage:Stored at -80°C for 1 year from date of receipt. It is stable at -20°C for 3 months after opening. It is recommended to freeze aliquots at -80°C for extended storage. Avoid repeated freeze-thaw cycles.
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Biological Activity
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Technical Parameters
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Product Properties
- Documentation
- Help & FAQs
Biological Activity
Description
TEAD2 Protein, Human (Depalmitoylated, sf9) is the recombinant human-derived TEAD2 protein, expressed by Sf9 insect cells, with tag free tag.
Background
TEAD2 is a transcription factor that plays a key role in the Hippo signaling pathway, which controls organ size and suppresses tumors by restricting proliferation and promoting apoptosis. The pathway's core involves a kinase cascade where MST1/MST2, complexed with SAV1, phosphorylates and activates LATS1/2 in complex with MOB1, leading to the phosphorylation and inactivation of the oncoproteins YAP1 and WWTR1/TAZ. TEAD2 mediates the gene expression of YAP1 and WWTR1/TAZ, regulating cell proliferation, migration, and epithelial-mesenchymal transition (EMT) induction. It binds to SPH and GT-IIC 'enhansons' (5'-GTGGAATGT-3') and may be involved in neural development gene regulation. Additionally, TEAD2 binds to the M-CAT motif.
Technical Parameters
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Species Human
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Source Sf9 insect cells
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Tag Tag Free
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Accession
Q15562-1 (A217-D447)
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Gene ID8463
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Protein Length
Partial
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Synonyms
TEAD2; TEF-4; TEA Domain Transcription Factor 2; ETF; TEF4; Transcriptional Enhancer Factor TEF-4; TEA Domain Family Member 2; TEAD-2
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AA Sequence
AWQARGLGTARLQLVEFSAFVEPPDAVDSYQRHLFVHISQHCPSPGAPPLESVDVRQIYDKFPEKKGGLRELYDRGPPHAFFLVKFWADLNWGPSGEEAGAGGSISSGGFYGVSSQYESLEHMTLTCSSKVCSFGKQVVEKVETERAQLEDGRFVYRLLRSPMCEYLVNFLHKLRQLPERYMMNSVLENFTILQVVTNRDTQELLLCTAYVFEVSTSERGAQHHIYRLVRD
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Predicted Molecular Mass
26.4 kDa
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Purity
≥ 90%, as determined by reducing SDS-PAGE.
Product Properties
Solution.
<1 EU/μg, determined by LAL method.
Please use rapid thawing with running water to thaw the protein.
Stored at -80°C for 1 year from date of receipt. It is stable at -20°C for 3 months after opening. It is recommended to freeze aliquots at -80°C for extended storage. Avoid repeated freeze-thaw cycles.
Shipping with dry ice.
Documentation
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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