1 Result for "

β-lactone ring

" in MedChemExpress (MCE) Product Catalog:
Products (1)

1 Results for "β-lactone ring" in MCE Product Catalog:

Cat. No.: HY-138990
CAS No.: 2351820-19-2
Target:  

Phospholipase Apoptosis

Research Areas:  

Inflammation/Immunology

GK563 is a selective Ca 2+-independent phospholipase A2 (GVIA iPLA2) inhibitor with an IC50 value of 1 nM. GK563 is 22000 times more active against GVIA iPLA2 than GIVA cPLA2. GK563 reduces β-cell apoptosis induced by proinflammatory cytokines, raising the possibility that it can be beneficial in countering autoimmune diseases, such as type 1 diabetes .
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