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3 Results for "
1,4-Naphthoquinone (Standard)
" in MedChemExpress (MCE) Product Catalog:
Products (3)
3 Results for "1,4-Naphthoquinone (Standard)" in MCE Product Catalog:
Cat. No.: HY-W015490R
CAS No.: 130-15-4
Research Areas:
1,4-Naphthoquinone is an inhibitor with broad-spectrum inhibitory activity targeting DNA polymerase, NF-κB and monoamine oxidase (MAO-A/B), with antibacterial and anti-biofilm efficacy. 1,4-Naphthoquinone is a competitive inhibitor of MAO-B (Ki=1.4 μM) and a non-competitive inhibitor of MAO-A (Ki=7.7 μM). 1,4-Naphthoquinone inhibits DNA polymerase pol α, β, γ, δ, ε, λ with IC50 ranging from 5.57-128 μM. 1,4-Naphthoquinone inhibits tumor cell proliferation, induces apoptosis and necrosis, and has anti-angiogenic and anti-inflammatory activities by inducing oxidative stress, depleting glutathione (GSH), inhibiting DNA polymerase-mediated DNA synthesis and blocking NF-κB nuclear translocation. 1,4-Naphthoquinone can be used in anti-bacterial , anti-tumor and anti-inflammatory studies, including inhibition of melanoma and colon cancer cell growth and endothelial cell function, as well as LPS-induced inflammation models .
Synonyms: DHNQ (Standard); 5,8-Dihydroxy-1,4-Naphthoquinone (Standard)
Category:
Quinones Juglandaceae Juglans sigillata Dode Phenols Polyphenols Plants Naphthalene Quinones
Target:
Target:
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Protocols
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