1 Result for "

1195786-61-8

" in MedChemExpress (MCE) Product Catalog:
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1 Results for "1195786-61-8" in MCE Product Catalog:

Cat. No.: HY-118184
CAS No.: 1195786-61-8
Target:  

PGE synthase

Research Areas:  

Cancer

AF3485 is a human mPGES-1 inhibitor that exhibits antitumor activity in vitro and in vivo. AF3485 inhibits tumor-associated angiogenesis by reducing PGE2 production, inhibiting EGFR signaling, and decreasing VEGF and FGF-2 expression. AF3485 reduced tumor growth in mice bearing human A431 xenograft tumors by subchronic administration.
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