1 Result for "

162681-53-0

" in MedChemExpress (MCE) Product Catalog:
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1 Results for "162681-53-0" in MCE Product Catalog:

(Z)-Onjisaponin B
(Z)-Onjisaponin B
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Cat. No.: HY-N2099A
CAS No.: 162681-53-0
Synonyms: (Z)-Senegin III
Category:  

Polygala senega L. Triterpenes Terpenoids Polygalaceae Plants Pentacyclic Triterpenoids

Target:  

Drug Derivative

(Z)-Onjisaponin B ((Z)-Senegin III) is a derivative of Onjisaponin B (HY-N2099). Onjisaponin B is an orally active natural product derived from Polygala tenuifolia. Onjisaponin B inhibits NF-κB p65. Onjisaponin B enhances autophagy and accelerates the degradation of mutant α-synuclein and huntingtin. Onjisaponin B reduces β-amyloid (Aβ) production. Onjisaponin B reduces radiation-induced cell apoptosis. Onjisaponin B has anti-oxidant and anti-inflammatory activities. Onjisaponin B can be used for neurological disease and radiation injury study, and its metabolite tenuifolin (TF) can enter the brain through the BBB .
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