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Results for "

2-adrenoceptor

" in MedChemExpress (MCE) Product Catalog:

By Targets:	5-HT Receptor (10) Adrenergic Receptor (202) Akt (7) Antibiotic (3) Apoptosis (13) Atg8/LC3 (1) Autophagy (7) Bacterial (2) Dopamine Receptor (13) Drug Derivative (1) Drug Isomer (1) Drug Metabolite (3) Endogenous Metabolite (4) Histamine Receptor (4) Histone Methyltransferase (5) Imidazoline Receptor (23) Influenza Virus (2) Isotope-Labeled Compounds (30) LDLR (8) mAChR (9) Monoamine Oxidase (3) mTOR (1) Ornithine decarboxylase (ODC) (1) Parasite (3) Phosphodiesterase (PDE) (4) Potassium Channel (1) Reactive Oxygen Species (ROS) (1) Reference Standards (45) Sodium Channel (1) Vasopressin Receptor (1) Wnt (6) β-catenin (6)
By Research Areas:	Cancer (41) Cardiovascular Disease (67) Endocrinology (89) Infection (8) Inflammation/Immunology (50) Metabolic Disease (15) Neurological Disease (84)

By Targets:

5-HT Receptor (10)

Adrenergic Receptor (202)

Akt (7)

Antibiotic (3)

Apoptosis (13)

Atg8/LC3 (1)

Autophagy (7)

Bacterial (2)

Dopamine Receptor (13)

Drug Derivative (1)

Drug Isomer (1)

Drug Metabolite (3)

Endogenous Metabolite (4)

Histamine Receptor (4)

Histone Methyltransferase (5)

Imidazoline Receptor (23)

Influenza Virus (2)

Isotope-Labeled Compounds (30)

LDLR (8)

mAChR (9)

Monoamine Oxidase (3)

mTOR (1)

Ornithine decarboxylase (ODC) (1)

Parasite (3)

Phosphodiesterase (PDE) (4)

Potassium Channel (1)

Reactive Oxygen Species (ROS) (1)

Reference Standards (45)

Sodium Channel (1)

Vasopressin Receptor (1)

Wnt (6)

β-catenin (6)

By Research Areas:

Cancer (41)

Cardiovascular Disease (67)

Endocrinology (89)

Infection (8)

Inflammation/Immunology (50)

Metabolic Disease (15)

Neurological Disease (84)

209

Inhibitors & Agonists

Natural
Products

Recombinant Proteins

Isotope-Labeled Compounds

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-17034A

Dexmedetomidine hydrochloride Maximum Cited Publications 26 Publications Verification (+)-Medetomidine hydrochloride; (S)-Medetomidine hydrochloride	Adrenergic Receptor	Infection Cancer
Dexmedetomidine hydrochloride ((+)-Medetomidine hydrochloride) is a potent, selective and orally active agonist of *α2-adrenoceptor, with a K_i* of 1.08 nM. Dexmedetomidine hydrochloride shows 1620-fold selectivity against α1-adrenoceptor. Dexmedetomidine hydrochloride exhibits anxiolysis, sedation, and modest analgesia effects ^[2] .

HY-12719

Dexmedetomidine Maximum Cited Publications 26 Publications Verification (+)-Medetomidine; (S)-Medetomidine	Adrenergic Receptor	Neurological Disease Cancer
Dexmedetomidine ((+)-Medetomidine) is a potent, selective and orally active agonist of *α2-adrenoceptor, with a K_i* of 1.08 nM. Dexmedetomidine shows 1620-fold selectivity against α1-adrenoceptor. Dexmedetomidine exhibits anxiolysis, sedation, and modest analgesia effects ^[2] .

HY-B0409A

Clonidine hydrochloride 5+ Cited Publications	Adrenergic Receptor	Cardiovascular Disease Endocrinology Cancer
Clonidine hydrochloride is an agonist of *α2-adrenoceptor* and potent antihypertensive agent.

HY-12380A

Atipamezole 5+ Cited Publications MPV 1248	Adrenergic Receptor	Neurological Disease Endocrinology
Atipamezole (MPV 1248) is a potent α₂-adrenoceptor antagonist with a K_i of 1.6 nM .

HY-14301

Olodaterol 1 Publications Verification BI1744	Adrenergic Receptor	Inflammation/Immunology Endocrinology
Olodaterol (BI1744) is a selective, long acting *β₂-adrenoceptor* (β₂-AR) agonist (EC₅₀=0.1 nM and pK_i= 9.14 for human β₂-adrenoceptor, respectively). Olodaterol can be used for chronic obstructive pulmonary disease (COPD) and pulmonary fibrosis ^[2] .

HY-12380

Atipamezole hydrochloride 5+ Cited Publications MPV-1248 hydrochloride	Adrenergic Receptor	Neurological Disease Endocrinology
Atipamezole (MPV-1248) hydrochloride is a potent α₂-adrenoceptor antagonist with a K_i of 1.6 nM .

HY-12710

Rauwolscine 1 Publications Verification α-Yohimbine; Corynanthidine; Isoyohimbine	Adrenergic Receptor	Cancer
Rauwolscine is a selective *α2-adrenoceptor* antagonist that inhibits tumor growth and induces apoptosis .

HY-B0976

Fenoterol Th-1165; Phenoterol	Adrenergic Receptor	Inflammation/Immunology Endocrinology
Fenoterol (Th-1165), a sympathomimetic agent, is a selective and orally active *β2-adrenoceptor* agonist. Fenoterol is an effective bronchodilator and can be used for bronchospasm associated with asthma, bronchitis and other obstructive airway diseases research ^[2].

HY-B0976A

Fenoterol hydrobromide Th-1165a; Phenoterol hydrobromide	Adrenergic Receptor	Inflammation/Immunology Endocrinology
Fenoterol hydrobromide (Th-1165a), a sympathomimetic agent, is a selective and orally active *β2-adrenoceptor* agonist. Fenoterol hydrobromide is an effective bronchodilator and can be used for bronchospasm associated with asthma, bronchitis and other obstructive airway diseases research ^[2].

HY-N1163

Tetrahydroalstonine (-)-Tetrahydroalstonine	Adrenergic Receptor Atg8/LC3 Akt mTOR	Neurological Disease Endocrinology
Tetrahydroalstonine ((-)-Tetrahydroalstonine) is an indole alkaloid and a selective α₂-adrenergic receptor antagonist. Tetrahydroalstonine exhibits certain neuroprotective effects. Tetrahydroalstonine can regulate autophagy-lysosomal function by activating the Akt/mTOR pathway, significantly reducing OGD/R-induced primary cortical neuronal injury ^[2] .

HY-100490

Rilmenidine	Imidazoline Receptor Adrenergic Receptor Apoptosis Autophagy	Cardiovascular Disease Cancer
Rilmenidine, an innovative antihypertensive agent, is an orally active, selective I1 imidazoline receptor agonist. Rilmenidine is an alpha 2-adrenoceptor agonist. Rilmenidine induces autophagy. Rilmenidine acts both centrally by reducing sympathetic overactivity and in the kidney by inhibiting the Na ⁺/H ⁺ antiport. Rilmenidine modulates proliferation and stimulates the proapoptotic protein Bax thus inducing the perturbation of the mitochondrial pathway and apoptosis in human leukemic K562 cells ^[2] .

HY-B0010

Formoterol fumarate 5+ Cited Publications (±)Formoterol fumarate	Adrenergic Receptor	Inflammation/Immunology
Formoterol fumarate ((±)Formoterol fumarate) is a selective *β₂-adrenoceptor* agonist. Formoterol fumarate is at least as β₂-adrenoceptor selective as Salbutamol (HY-B1037) and Terbutaline (HY-B0802A). Formoterol fumarate abolishs the contraction induced by Acetylcholine in bronchioles. Formoterol fumarate can be used for the research of chronic obstructive pulmonary disease and bronchial asthma ^[2].

HY-B1810

Tulobuterol 2 Publications Verification C-78 free base	Adrenergic Receptor	Inflammation/Immunology Endocrinology
Tulobuterol (C-78 free base) is a long-acting *β₂-adrenoceptor* agonist, which reduces the frequency of exacerbations of chronic obstructive pulmonary disease and bronchial asthma. Tulobuterol is also a sympathomimetic agent used as a transdermal patch, and increases normal diaphragm muscle strength .

HY-100490B

Rilmenidine phosphate	Imidazoline Receptor Adrenergic Receptor Apoptosis Autophagy	Cardiovascular Disease Cancer
Rilmenidine phosphate, an innovative antihypertensive agent, is an orally active, selective I1 imidazoline receptor agonist. Rilmenidine phosphate is an alpha 2-adrenoceptor agonist. Rilmenidine phosphate induces autophagy. Rilmenidine phosphate acts both centrally by reducing sympathetic overactivity and in the kidney by inhibiting the Na ⁺/H ⁺ antiport. Rilmenidine phosphate modulates proliferation and stimulates the proapoptotic protein Bax thus inducing the perturbation of the mitochondrial pathway and apoptosis in human leukemic K562 cells ^[2] .

HY-12463

Carmoterol hydrochloride	Adrenergic Receptor	Inflammation/Immunology
Carmoterol hydrochloride is a highly potent, selective and long-acting *β2-adrenoceptor* agonist with the pEC₅₀ of 10.19. Carmoterol has 53 times higher affinity for the β2-adrenoceptors than for the β1-adrenoceptors. Carmoterol hydrochloride can be used for the research of asthma and chronic obstructive pulmonary disease (COPD) ^[2].

HY-17034

Medetomidine	Adrenergic Receptor	Neurological Disease Endocrinology
Medetomidine is an orally active *α2-adrenoceptor* agonist (K_i: 1.08 nM). Medetomidine has sedative and analgesic effects. Medetomidine can cause peripheral vasoconstriction through the activation of α2 adrenoceptors on blood vessels ^[2] .

HY-W744625

Olodaterol-d3 hydrochloride BI1744-d3 hydrochloride	Isotope-Labeled Compounds Adrenergic Receptor	Endocrinology
Olodaterol-d₃ hydrochloride (BI1744-d₃ hydrochloride) is the deuterium labeled Olodaterol hydrochloride (HY-14301A). Olodaterol (BI1744) hydrochloride is a selective, long acting β2-adrenoceptor (β2-AR) agonist (EC₅₀=0.1 nM and pKi= 9.14 for human β2-adrenoceptor, respectively). Olodaterol can be used for chronic obstructive pulmonary disease (COPD) and pulmonary fibrosis ^[2] .

HY-12724

Guanabenz 2 Publications Verification	Adrenergic Receptor Parasite	Cardiovascular Disease Cancer
Guanabenz is an orally active *α-2-adrenoceptor* agonist. Guanabenz has antihypertensive effect and antiparasitic activity. Guanabenz interferes ER stress-signalling and has protective effects in cardiac myocytes. Guanabenz also is used for the research of high blood pressure ^[2] .

HY-12980

Batefenterol GSK961081; TD-5959	Adrenergic Receptor mAChR	Inflammation/Immunology Endocrinology
Batefenterol (GSK961081;TD-5959) is a novel muscarinic receptor antagonist and *β₂-adrenoceptor* agonist; displays high affinity for hM2, hM3 muscarinic and hβ₂-adrenoceptor with K_i values of 1.4, 1.3 and 3.7 nM, respectively.

HY-14301A

Olodaterol hydrochloride 1 Publications Verification BI1744 hydrochloride	Adrenergic Receptor	Inflammation/Immunology Endocrinology
Olodaterol (BI1744) hydrochloride is a selective, long acting *β₂-adrenoceptor* (β₂-AR) agonist (EC₅₀=0.1 nM and pK_i= 9.14 for human β₂-adrenoceptor, respectively). Olodaterol can be used for chronic obstructive pulmonary disease (COPD) and pulmonary fibrosis ^[2] .

HY-17034B

Medetomidine hydrochloride MPV785	Adrenergic Receptor	Neurological Disease Endocrinology
Medetomidine hydrochloride is an orally active *α2-adrenoceptor* agonist (K_i: 1.08 nM). Medetomidine hydrochloride has sedative and analgesic effects. Medetomidine hydrochloride can cause peripheral vasoconstriction through the activation of α2 adrenoceptors on blood vessels ^[2] .

HY-101355B

CGP 20712 A CGP 20712 mesylate	Adrenergic Receptor	Cardiovascular Disease
CGP 20712 A (CGP 20712 mesylate) is a highly selective *β1-adrenoceptor* antagonist with an IC₅₀ of 0.7 nM. CGP 20712 A exhibits ~10,000-fold selectivity over β2-adrenoceptors .

HY-12724A

Guanabenz hydrochloride	Parasite Adrenergic Receptor	Cardiovascular Disease Cancer
Guanabenz hydrochloride is an orally active *α-2-adrenoceptor* agonist. Guanabenz hydrochloride has antihypertensive effect and antiparasitic activity. Guanabenz hydrochloride interferes ER stress-signalling and has protective effects in cardiac myocytes. Guanabenz hydrochloride also is used for the research of high blood pressure ^[2] .

HY-100490A

Rilmenidine hemifumarate	Imidazoline Receptor Adrenergic Receptor Apoptosis Autophagy	Cardiovascular Disease Cancer
Rilmenidine hemifumarate, an innovative antihypertensive agent, is an orally active, selective I1 imidazoline receptor agonist. Rilmenidine hemifumarate is an alpha 2-adrenoceptor agonist. Rilmenidine hemifumarate induces autophagy. Rilmenidine hemifumarate acts both centrally by reducing sympathetic overactivity and in the kidney by inhibiting the Na ⁺/H ⁺ antiport. Rilmenidine hemifumarate modulates proliferation and stimulates the proapoptotic protein Bax thus inducing the perturbation of the mitochondrial pathway and apoptosis in human leukemic K562 cells ^[2] .

HY-14304A

Zinterol hydrochloride 1 Publications Verification MJ 9184 hydrochloride	Adrenergic Receptor	Cardiovascular Disease
Zinterol hydrochloride (MJ 9184 hydrochloride) is a potent and selective *β2-adrenoceptor* agonist . Zinterol hydrochloride increases I_Ca in a concentration-dependent manner with an EC₅₀ of 2.2 nM ^[2]. Zinterol hydrochloride induces ventricular arrhythmias in conscious heart failure rabbits .

HY-135490

Reproterol	Adrenergic Receptor Phosphodiesterase (PDE)	Inflammation/Immunology
Reproterol is a selective *β2-adrenoceptor* agonist and cAMP phosphodiesterase (PDE) inhibitor. Reproterol inhibits adenylate cyclase-induced phosphodiesterase activity. Reproterol inhibits histamine release from mast cells. Reproterol is applicable to research related to asthma .

HY-108901

Formoterol hemifumarate hydrate 5+ Cited Publications	Adrenergic Receptor	Neurological Disease Inflammation/Immunology
Formoterol hemifumarate hydrate is a selective, long-acting beta 2-adrenoceptor agonist. Formoterol is a bronchodilator used for the research of the asthma and chronic obstructive pulmonary disease (COPD). Formoterol hemifumarate hydrate induces mitochondrial biogenesis and promotes cognitive recovery after traumatic brain injury ^[2] .

HY-103197

2-Methoxyidazoxan monohydrochloride RX821002 hydrochloride	Adrenergic Receptor	Neurological Disease
2-Methoxyidazoxan monohydrochloride (RX821002 hydrochloride) is a highly selective alpha 2-adrenoceptor antagonist with little or no imidazoline antagonist effect. RX 821002 has markedly higher affinity for (guinea-pig) alpha 2D-adrenoceptors (pK_d 9.7) than for (rabbit) alpha 2A-adrenoceptors (pK_d 8.2) ^[2].

HY-111144

Abediterol AZD0548; LAS100977	Adrenergic Receptor	Inflammation/Immunology
Abediterol (LAS100977) is an inhaled long-acting *β2-adrenoceptor* agonist (LABA) and can be used for the research of asthma and chronic obstructive pulmonary disease (COPD) .

HY-B1416A

Efaroxan hydrochloride	Adrenergic Receptor Imidazoline Receptor	Cardiovascular Disease Metabolic Disease
Efaroxan hydrochloride is a potent, selective and orally active *α2-adrenoceptor* antagonist, with antidiabetic activity. Efaroxan hydrochloride is a selective I1-Imidazoline receptor antagonist. Efaroxan hydrochloride can be used for the research of cardiovascular disease ^[2] .

HY-50291

HOKU-81 4-Hydroxytulobuterol	Adrenergic Receptor	Cardiovascular Disease Endocrinology
HOKU-81 (4-Hydroxytulobuterol) is one of the metabolites of Tulobuterol (HY-B1810). HOKU-81 is a potent and selective *β2-adrenoceptor* stimulant. HOKU-81 has bronchodilating effect ^[2].

HY-106769

Fluparoxan GR50360	Adrenergic Receptor	Neurological Disease
Fluparoxan is an orally active, selective and competitive alpha 2-adrenoceptor antagonist. Fluparoxan is an anti-depressant agent ^[2].

HY-14301AR

Olodaterol hydrochloride (Standard) BI1744 hydrochloride (Standard)	Reference Standards Adrenergic Receptor	Inflammation/Immunology Endocrinology
Olodaterol (hydrochloride) (Standard) is the analytical standard of Olodaterol (hydrochloride). This product is intended for research and analytical applications. Olodaterol (BI1744) hydrochloride is a selective, long acting *β₂-adrenoceptor* (β₂-AR) agonist (EC₅₀=0.1 nM and pK_i= 9.14 for human β₂-adrenoceptor, respectively). Olodaterol can be used for chronic obstructive pulmonary disease (COPD) and pulmonary fibrosis ^[2] .

HY-17034BS1

Medetomidine-13C,d3 hydrochloride MPV785-¹³C,d₃	Isotope-Labeled Compounds Adrenergic Receptor	Endocrinology
Medetomidine-13C,d3 (hydrochloride) is a deuterated labeled Medetomidine (hydrochloride) . Medetomidine hydrochloride is an orally active *α2-adrenoceptor* agonist (K_i: 1.08 nM). Medetomidine hydrochloride has sedative and analgesic effects. Medetomidine hydrochloride can cause peripheral vasoconstriction through the activation of α2 adrenoceptors on blood vessels ^[2] .

HY-103203

ST91	Adrenergic Receptor	Neurological Disease
ST91 is a **α₂-adrenoceptor (α₂AR)** agonist. ST91 activates both α_2AAR and non-α_2AAR subtypes to produce spinal antinociception ^[2] .

HY-N3298

Meranzin	Adrenergic Receptor	Cardiovascular Disease Neurological Disease
Meranzin is an absorbed bioactive compound from the Traditional Chinese Medicine (TCM) Chaihu-Shugan-San (CSS). Meranzin, isolated from leaves of Murraya exotica L., regulates the shared alpha 2-adrenoceptor and involves the AMPA-ERK1/2–BDNF signaling pathway. Meranzin has the potential for the prevention of the comorbidity of atherosclerosis and depression ^[2].

HY-136409R

N-Decanoyl-L-homoserine lactone (Standard) C10-HSL (Standard)	Reference Standards Bacterial Reactive Oxygen Species (ROS)	Infection
Formoterol (hemifumarate hydrate) (Standard) is the analytical standard of Formoterol (hemifumarate hydrate). This product is intended for research and analytical applications. Formoterol hemifumarate hydrate is a selective, long-acting beta 2-adrenoceptor agonist. Formoterol is a bronchodilator used for the research of the asthma and chronic obstructive pulmonary disease (COPD). Formoterol hemifumarate hydrate induces mitochondrial biogenesis and promotes cognitive recovery after traumatic brain injury ^[2] .

HY-103212A

Azepexole hydrochloride B-HT 933 hydrochloride; Oxazoloazepin hydrochloride	Adrenergic Receptor	Cardiovascular Disease
Azepexole hydrochloride (B-HT 933 dihydrochloride; Oxazoloazepin dihydrochloride) is a selective agonist for α 2-adrenoceptor, with pK_i of 8.3, 7.6, and 7.5 for α2A-, α2B- and α2C-adrenoceptor subtypes, resepctively. Azepexole dihydrochloride causes concentration-dependent inhibition of peristaltic contractions with IC₅₀ of 78.72 nM. Azepexole hydrochloride exhibits antitussive and analgesic efficacy ^[2].

HY-155879

(±)-N-Methylcoclaurine	Adrenergic Receptor	Others
(±)-N-Methylcoclaurine is a selective α2-adrenoceptor antagonist .

HY-119868

Butaxamine Butoxamin	Adrenergic Receptor	Metabolic Disease
Butaxamine (Butoxamin) is a potent, selective and orally active *β2-adrenoceptor* antagonist. Butaxamine shows antiosteoporotic activity .

HY-N3198A

Sophoramine 1 Publications Verification (-)-Sophoramine	Adrenergic Receptor	Cardiovascular Disease
Sophoramine ((-)-Sophoramine) is a prejunctional *α₂-adrenoceptor* inhibitor that can be found in the seeds of Sophora alopecuroides. Sophoramine inhibits prejunctional α2-adrenoceptors to facilitate norepinephrine release from adrenergic nerves. Sophoramine shows cytotoxic activity against human cancer cells, positive inotropic activity, and activity in rodent arrhythmia models. Sophoramine can be used for the research of arrhythmias ^[2].

HY-B0010S

Formoterol-d6 (±)Formoterol-d₆	Isotope-Labeled Compounds Adrenergic Receptor	Inflammation/Immunology Endocrinology
Formoterol-d₆ is the deuterium labeled Formoterol. Formoterol ((±)Formoterol) is a potent, selective and long-acting β2-adrenoceptor agonist .

HY-A0008

Talipexole dihydrochloride B-HT 920 dihydrochloride	Adrenergic Receptor Dopamine Receptor 5-HT Receptor	Neurological Disease Endocrinology
Talipexole dihydrochloride (B-HT 920 dihydrochloride) is a dopamine D2 receptor agonist, α2-adrenoceptor agonist and 5-HT3 receptor antagonist, which displays antiParkinsonian activity.

HY-101355A

CGP 20712 dihydrochloride	Adrenergic Receptor	Neurological Disease Endocrinology
CGP 20712 dihydrochloride is a highly selective *β1-adrenoceptor* antagonist with an IC₅₀ of 0.7 nM. CGP 20712 dihydrochloride exhibits ~10,000-fold selectivity over β2-adrenoceptors .

HY-148529

Midaglizole (±)-DG5128 free base; DG5128 free base	Adrenergic Receptor	Cardiovascular Disease Metabolic Disease
Midaglizole ((±)-DG5128 free base, DG5128 free base) is a potent *α2-adrenoceptor* antagonist. Midaglizole is a hypoglycemic agent. Midaglizole increases blood pressure and reduces blood glucose levels in vivo ^[2] .

HY-136435

Mapenterol hydrochloride	Adrenergic Receptor	Endocrinology
Mapenterol hydrochloride is a type of *β2-adrenoceptor* agonist .

HY-19942A

TD-5471 hydrochloride	Adrenergic Receptor	Metabolic Disease Endocrinology
TD-5471 hydrochloride is a potent and selective full agonist of the human *β₂-adrenoceptor*.

HY-B0409S

Clonidine-d4	Isotope-Labeled Compounds Adrenergic Receptor	Cardiovascular Disease Endocrinology Cancer
Clonidine-d₄ is the deuterium labeled Clonidine. Clonidine hydrochloride is an agonist of α2-adrenoceptor and potent antihypertensive agent ^[2] .

HY-136935

Alloyohimbine	Adrenergic Receptor	Endocrinology
Alloyohimbine, an alkaloid, is a selective *α2-adrenoceptor* antagonist with K_Dα1, K_Dα2 of 0.28 μM and 0.006 μM, respectively .

HY-106769C

Fluparoxan hydrochloride GR50360 hydrochloride	Adrenergic Receptor	Neurological Disease
Fluparoxan hydrochloride is an orally active, selective and competitive alpha 2-adrenoceptor antagonist. Fluparoxan hydrochloride is an anti-depressant agent ^[2].

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-12710

Rauwolscine 1 Publications Verification α-Yohimbine; Corynanthidine; Isoyohimbine	Apocynaceae Rauvolfia tetraphylla Linn. Alkaloids Plants Indole Alkaloids Source Classification	Adrenergic Receptor
Rauwolscine is a selective *α2-adrenoceptor* antagonist that inhibits tumor growth and induces apoptosis .

HY-N1163

Tetrahydroalstonine (-)-Tetrahydroalstonine	Apocynaceae Alkaloids Plants Indole Alkaloids Catharanthus roseus (L.) G. Don Source Classification	Adrenergic Receptor Atg8/LC3 Akt mTOR
Tetrahydroalstonine ((-)-Tetrahydroalstonine) is an indole alkaloid and a selective α₂-adrenergic receptor antagonist. Tetrahydroalstonine exhibits certain neuroprotective effects. Tetrahydroalstonine can regulate autophagy-lysosomal function by activating the Akt/mTOR pathway, significantly reducing OGD/R-induced primary cortical neuronal injury ^[2] .

HY-B0528A

Octopamine hydrochloride 5 Publications Verification (±)-p-Octopamine hydrochloride	Structural Classification Monophenols Neurological Disease Classification of Application Fields Phenols Endogenous metabolite Disease Research Fields Endocrinology Source Classification	Adrenergic Receptor Endogenous Metabolite
Octopamine ((±)-p-Octopamine) hydrochloride, a biogenic monoamine structurally related to noradrenaline, acts as a neurohormone, a neuromodulator and a neurotransmitter in invertebrates. Octopamine hydrochloride can stimulate alpha2-adrenoceptors (ARs) in Chinese hamster ovary cells transfected with human alpha2-ARs. Octopamine hydrochloride increased glycogenolysis, glycolysis, oxygen uptake, gluconeogenesis and the portal perfusion pressure ^[2] .

HY-B0528AR

Octopamine hydrochloride (Standard) (±)-p-Octopamine hydrochloride (Standard)	Structural Classification Monophenols Phenols Endogenous metabolite Source Classification	Reference Standards Adrenergic Receptor Endogenous Metabolite
Octopamine (hydrochloride) (Standard) is the analytical standard of Octopamine (hydrochloride). This product is intended for research and analytical applications. Octopamine ((±)-p-Octopamine) hydrochloride, a biogenic monoamine structurally related to noradrenaline, acts as a neurohormone, a neuromodulator and a neurotransmitter in invertebrates. Octopamine hydrochloride can stimulate alpha2-adrenoceptors (ARs) in Chinese hamster ovary cells transfected with human alpha2-ARs. Octopamine hydrochloride increased glycogenolysis, glycolysis, oxygen uptake, gluconeogenesis and the portal perfusion pressure ^[2] .

HY-N3298

Meranzin	Cardiovascular Disease other families Classification of Application Fields Neurological Disease Coumarins Phenylpropanoids Plants Disease Research Fields Source Classification	Adrenergic Receptor
Meranzin is an absorbed bioactive compound from the Traditional Chinese Medicine (TCM) Chaihu-Shugan-San (CSS). Meranzin, isolated from leaves of Murraya exotica L., regulates the shared alpha 2-adrenoceptor and involves the AMPA-ERK1/2–BDNF signaling pathway. Meranzin has the potential for the prevention of the comorbidity of atherosclerosis and depression ^[2].

HY-136409R

N-Decanoyl-L-homoserine lactone (Standard) C10-HSL (Standard)	Microorganisms Source Classification	Reference Standards Bacterial Reactive Oxygen Species (ROS)
Formoterol (hemifumarate hydrate) (Standard) is the analytical standard of Formoterol (hemifumarate hydrate). This product is intended for research and analytical applications. Formoterol hemifumarate hydrate is a selective, long-acting beta 2-adrenoceptor agonist. Formoterol is a bronchodilator used for the research of the asthma and chronic obstructive pulmonary disease (COPD). Formoterol hemifumarate hydrate induces mitochondrial biogenesis and promotes cognitive recovery after traumatic brain injury ^[2] .

HY-N3198A

Sophoramine 1 Publications Verification (-)-Sophoramine	Alkaloids Structural Classification Classification of Application Fields Leguminosae Other Diseases Pyridine Alkaloids Sophora flavescens Aiton Plants Disease Research Fields Source Classification	Adrenergic Receptor
Sophoramine ((-)-Sophoramine) is a prejunctional *α₂-adrenoceptor* inhibitor that can be found in the seeds of Sophora alopecuroides. Sophoramine inhibits prejunctional α2-adrenoceptors to facilitate norepinephrine release from adrenergic nerves. Sophoramine shows cytotoxic activity against human cancer cells, positive inotropic activity, and activity in rodent arrhythmia models. Sophoramine can be used for the research of arrhythmias ^[2].

HY-B0528

Octopamine	Monophenols Microorganisms Phenols Source Classification	Adrenergic Receptor Endogenous Metabolite
Octopamine is a biogenic monoamine structurally related to noradrenaline, acts as a neurohormone, a neuromodulator and a neurotransmitter in invertebrates. Octopamine can stimulate alpha2-adrenoceptors (ARs) in Chinese hamster ovary cells transfected with human alpha2-ARs. Octopamine increased glycogenolysis, glycolysis, oxygen uptake, gluconeogenesis and the portal perfusion pressure ^[2] .

HY-136935

Alloyohimbine	Apocynaceae Alkaloids Alstonia scholaris (L.) R. Br. Plants Indole Alkaloids Source Classification	Adrenergic Receptor
Alloyohimbine, an alkaloid, is a selective *α2-adrenoceptor* antagonist with K_Dα1, K_Dα2 of 0.28 μM and 0.006 μM, respectively .

HY-101392R

Harmane (Standard)	Alkaloids other families Plants Source Classification	Reference Standards Imidazoline Receptor Monoamine Oxidase Adrenergic Receptor
Harmane (Standard) is the analytical standard of Harmane. This product is intended for research and analytical applications. Harmane, a β-Carboline alkaloid (BCA), is a potent neurotoxin that causes severe action tremors and psychiatric manifestations. Harmane shows 1000-fold selectivity for I1-Imidazoline receptor (IC₅₀=30 nM) over *α2-adrenoceptor* (IC₅₀=18 μM). Harmane is also a potent and selective inhibitor of monoamine oxidase (MAO) (IC₅₀s=0.5 and 5 μM for human MAO A/B, respectively). Harmane exhibits comutagenic effect ^[2] .

HY-N3298R

Meranzin (Standard)	Structural Classification other families Coumarins Phenylpropanoids Plants Source Classification	Reference Standards Adrenergic Receptor
Meranzin (Standard) is the analytical standard of Meranzin. This product is intended for research and analytical applications. Meranzin is an absorbed bioactive compound from the Traditional Chinese Medicine (TCM) Chaihu-Shugan-San (CSS). Meranzin, isolated from leaves of Murraya exotica L., regulates the shared alpha 2-adrenoceptor and involves the AMPA-ERK1/2–BDNF signaling pathway. Meranzin has the potential for the prevention of the comorbidity of atherosclerosis and depression ^[2].

HY-N8268R

Nordeoxycholic acid (Standard) 3α,12α-Dihydroxynorcholanic acid (Standard)	Animals Source Classification	Drug Metabolite Reference Standards
Reproterol (hydrochloride) (Standard) is the analytical standard of Reproterol (hydrochloride). This product is intended for research and analytical applications. Reproterol hydrochloride is a dual-acting beta2-adrenoceptor agonist and phosphodiesterase inhibitor. Reproterol hydrochloride is more potent than albuterol and feterol in stimulating cAMP production in human monocytes, demonstrating its potential in enhancing airway function. Furthermore, Reproterol significantly inhibited the production of LTB4, indicating its anti-inflammatory properties. Reproterol hydrochloride may have inhibitory effects in respiratory diseases such as asthma and COPD .

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HY-P702206

	ADRB2 Protein, Human (G16R, E27Q, Cell-Free, His, SUMO) Beta-2 adrenergic receptor; Beta-2 adrenoreceptor; Beta-2 adrenoceptor	Human	E. coli Cell-free
	ADRB2 protein is an important member of the β-adrenergic receptor family and mediates catecholamine-induced adenylyl cyclase activation through G protein action. It has 30 times greater affinity for epinephrine and plays a crucial role in cellular responses to sympathetic nervous system stimulation. ADRB2 Protein, Human (Cell-Free, His, SUMO) is the recombinant human-derived ADRB2 protein, expressed by E. coli Cell-free , with N-6*His, N-SUMO labeled tag with mutatant of G16R, E27Q.

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Cat. No.	Product Name	Chemical Structure

HY-W744625

Olodaterol-d3 hydrochloride
Olodaterol-d₃ hydrochloride (BI1744-d₃ hydrochloride) is the deuterium labeled Olodaterol hydrochloride (HY-14301A). Olodaterol (BI1744) hydrochloride is a selective, long acting β2-adrenoceptor (β2-AR) agonist (EC₅₀=0.1 nM and pKi= 9.14 for human β2-adrenoceptor, respectively). Olodaterol can be used for chronic obstructive pulmonary disease (COPD) and pulmonary fibrosis ^[2] .

HY-17034BS1

Medetomidine-13C,d3 hydrochloride
Medetomidine-13C,d3 (hydrochloride) is a deuterated labeled Medetomidine (hydrochloride) . Medetomidine hydrochloride is an orally active *α2-adrenoceptor* agonist (K_i: 1.08 nM). Medetomidine hydrochloride has sedative and analgesic effects. Medetomidine hydrochloride can cause peripheral vasoconstriction through the activation of α2 adrenoceptors on blood vessels ^[2] .

HY-B0010S

Formoterol-d6
Formoterol-d₆ is the deuterium labeled Formoterol. Formoterol ((±)Formoterol) is a potent, selective and long-acting β2-adrenoceptor agonist .

HY-B0194S

Tizanidine-d4

Tizanidine-d₄ is the deuterium labeled Tizanidine (HY-B0194). Tizanidine, a skeletal muscle relaxant, is an orally effective central α₂-adrenoceptor agonist (IC₅₀ = 6.9 nmol). Tizanidine primarily exerts muscle relaxation effects by inhibiting the release of excitatory amino acids (glutamate and aspartate) from the presynaptic terminals of spinal cord interneurons. Tizanidine has anti-injury activity and can inhibit gastrointestinal (GI) transport. Tizanidine can inhibit the proliferation, migration, and invasion of lung cancer cells and induce cell apoptosis by upregulating Nischarin and inhibiting the AKT and Wnt3a/β-catenin signaling pathways. Tizanidine can be used to treat spasticity caused by diseases such as multiple sclerosis (MS), stroke, and spinal cord injury (SCI).

HY-135119

Salmeterol-d3
Salmeterol-d₃ is a deuterium labeled Salmeterol. Salmeterol is a potent and selective human β2 adrenoceptor agonist. Salmeterol shows potent stimulation of cAMP accumulation in CHO cells expressing human β2, β1 and β3 adrenoceptors with pEC₅₀s of 9.6, 6.1, and 5.9, respectively .

HY-B0409S

Clonidine-d4
Clonidine-d₄ is the deuterium labeled Clonidine. Clonidine hydrochloride is an agonist of α2-adrenoceptor and potent antihypertensive agent ^[2] .

HY-17034AS

Dexmedetomidine-13C,d3 hydrochloride

Dexmedetomidine- ¹³C,d₃ (hydrochloride) is the ¹³C- and deuterium labeled Dexmedetomidine (hydrochloride). Dexmedetomidine hydrochloride ((+)-Medetomidine hydrochloride) is a potent, selective and orally active agonist of α2-adrenoceptor, with a K_i of 1.08 nM. Dexmedetomidine hydrochloride shows 1620-fold selectivity against α1-adrenoceptor. Dexmedetomidine hydrochloride exhibits anxiolysis, sedation, and modest analgesia effects ^[2] .

HY-B0352S3

Mirtazapine-d4 hydrochloride
Mirtazapine-d₄ hydrochloride is deuterated labeled Mirtazapine (HY-B0352). Mirtazapine (Org3770) is a potent and orally active noradrenergic and specific serotonergic antidepressant (NaSSA) agent. Mirtazapine is also a *5-HT₂, 5-HT₃, histamine H1 receptor* and *α2-adrenoceptor* antagonist with pK_i values of 8.05, 8.1, 9.3 and 6.95, respectively ^[2].

HY-B0374S

Moxonidine-d4

Moxonidine-d₄ (BDF5895-d₄) is the deuterium labeled Moxonidine (HY-B0374). Moxonidine (BDF5895) is an orally active imidazoline type 1 receptor (I₁-R) agonist. Moxonidine activates imidazoline I₁ receptors and α₂ adrenoceptors, affecting oxidized low-density lipoprotein uptake. Moxonidine reduces atherosclerotic lesions and lowers blood pressure. Moxonidine can be used in the study of hypertension, heart failure, and atherosclerosis ^[2] .

HY-100490S

Rilmenidine-d4

Rilmenidine-d₄ is the deuterium labeled Rilmenidine. Rilmenidine, an innovative antihypertensive agent, is an orally active, selective I1 imidazoline receptor agonist. Rilmenidine is an alpha 2-adrenoceptor agonist. Rilmenidine induces autophagy. Rilmenidine acts both centrally by reducing sympathetic overactivity and in the kidney by inhibiting the Na+/H+ antiport. Rilmenidine modulates proliferation and stimulates the proapoptotic protein Bax thus inducing the perturbation of the mitochondrial pathway and apoptosis in human leukemic K562 cells ^[2] .

HY-136435S1

Mapenterol-d6 hydrochloride
Mapenterol-d₆ (hydrochloride) is the deuterium labeled Mapenterol hydrochloride. Mapenterol hydrochloride is a type of β2-adrenoceptor agonist ^[2].

HY-W717221

Medetomidine-d5 (d5-Major)
Medetomidine-d₅ (d5-Major) is the deuterium labeled Medetomidine (HY-17034). Medetomidine is an orally active α2-adrenoceptor agonist (Ki: 1.08 nM). Medetomidine has sedative and analgesic effects. Medetomidine can cause peripheral vasoconstriction through the activation of α2 adrenoceptors on blood vessels ^[2] .

HY-W759997

Reproterol-d3
Reproterol-d₃ is the deuterium labeled Reproterol (HY-135490). Reproterol is a dual acting β2-adrenoceptor agonist and PDE inhibitor. The theophylline constituent of Reproterol inhibits phosphodiesterase activity induced by adenylyl cyclase. Reproterol has the potential for asthma research ^[2].

HY-157502S

Buctopamine-d9
Buctopamine-d9 is the deuterium labeled Buctopamine. Buctopamine is a β2 adrenoceptor agonist .

HY-B1810S

Tulobuterol-d9 hydrochloride
Tulobuterol-d₉ (hydrochloride) is the deuterium labeled Tulobuterol. Tulobuterol (C-78 free base) is a long-acting β2-adrenoceptor agonist, which reduces the frequency of exacerbations of chronic obstructive pulmonary disease and bronchial asthma. Tulobuterol is also a sympathomimetic agent used as a transdermal patch, and increases normal diaphragm muscle strength .

HY-B0976AS

Fenoterol-d6 hydrobromide
Fenoterol-d₆ (hydrobromide) (Th-1165a-d₆) is the deuterium labeled Fenoterol hydrobromide. Fenoterol hydrobromide (Th-1165a), a sympathomimetic agent, is a selective and orally active β2-adrenoceptor agonist. Fenoterol hydrobromide is an effective bronchodilator and can be used for bronchospasm associated with asthma, bronchitis and other obstructive airway diseases research ^[2].

HY-B0352S2

Mirtazapine-d4
Mirtazapine-d₄ is deuterium labeled Mirtazapine. Mirtazapine (Org3770) is a potent and orally active noradrenergic and specific serotonergic antidepressant (NaSSA) agent. Mirtazapine is also a 5-HT2, 5-HT3, histamine H1 receptor and α2-adrenoceptor antagonist with pKi values of 8.05, 8.1, 9.3 and 6.95, respectively ^[2].

HY-B0528AS

Octopamine-d4 hydrochloride

Octopamine-d₄ (hydrochloride) is the deuterium labeled Octopamine hydrochloride. Octopamine ((±)-p-Octopamine) hydrochloride, a biogenic monoamine structurally related to noradrenaline, acts as a neurohormone, a neuromodulator and a neurotransmitter in invertebrates. Octopamine hydrochloride can stimulate alpha2-adrenoceptors (ARs) in Chinese hamster ovary cells transfected with human alpha2-ARs. Octopamine hydrochloride increased glycogenolysis, glycolysis, oxygen uptake, gluconeogenesis and the portal perfusion pressure ^[2] .

HY-101392S

Harmane-d1

Harmane-d is the deuterium labeled Harmane. Harmane, a β-Carboline alkaloid (BCA), is a potent neurotoxin that causes severe action tremors and psychiatric manifestations. Harmane shows 1000-fold selectivity for I1-Imidazoline receptor (IC₅₀=30 nM) over α2-adrenoceptor (IC₅₀=18 μM). Harmane is also a potent and selective inhibitor of monoamine oxidase (MAO) (IC₅₀s=0.5 and 5 μM for human MAO A/B, respectively) ^[2] .

HY-14300S2

Vilanterol-d12
Vilanterol-d₁₂ (GW642444-d₁₂) is deuterium labeled Vilanterol. Vilanterol (GW642444) is a long-acting *β₂-adrenoceptor* (β₂-AR) agonist with 24 h activity. The pEC₅₀s for β₂-AR,β₁-AR and β₃-AR is 10.37±0.05, 6.98±0.03 and 7.36±0.03, respectively.

HY-101392S1

Harmane-d2

Harmane-d₂ is the deuterium labeled Harmane. Harmane, a β-Carboline alkaloid (BCA), is a potent neurotoxin that causes severe action tremors and psychiatric manifestations. Harmane shows 1000-fold selectivity for I1-Imidazoline receptor (IC₅₀=30 nM) over α2-adrenoceptor (IC₅₀=18 μM). Harmane is also a potent and selective inhibitor of monoamine oxidase (MAO) (IC₅₀s=0.5 and 5 μM for human MAO A/B, respectively) ^[2] .

HY-B0194AS

Tizanidine-d4 hydrochloride

Tizanidine-d₄ hydrochloride is deuterium labeled Tizanidine hydrochloride (HY-B0194A). Tizanidine hydrochloride, a skeletal muscle relaxant, is an orally effective central α₂-adrenoceptor agonist (IC₅₀ = 6.9 nmol). Tizanidine hydrochloride primarily exerts muscle relaxation effects by inhibiting the release of excitatory amino acids (glutamate and aspartate) from the presynaptic terminals of spinal cord interneurons. Tizanidine hydrochloride has anti-injury activity and can inhibit gastrointestinal (GI) transport. Tizanidine hydrochloride can inhibit the proliferation, migration, and invasion of lung cancer cells and induce cell apoptosis by upregulating Nischarin and inhibiting the AKT and Wnt3a/β-catenin signaling pathways. Tizanidine hydrochloride can be used to treat spasticity caused by diseases such as multiple sclerosis (MS), stroke, and spinal cord injury (SCI).

HY-107327S

Carazolol-d7
Carazolol-d₇ is the deuterium labeled Carazolol (HY-107327). Carazolol is a highly potent antagonist of *β₁/β₂ adrenoceptor. Carazolol is also a potent, selective β₃-adrenoceptor* agonist. Carazolol can be used in the research of hypertension .

HY-107327S1

Carazolol-d7 hydrochloride
Carazolol-d₇ (hydrochloride) is the deuterium labeled Carazolol hydrochloride (HY-W517264). Carazolol hydrochloride is a highly potent antagonist of *β₁/β₂ adrenoceptor. Carazolol hydrochloride is also a potent, selective β₃-adrenoceptor* agonist. Carazolol hydrochloride can be used in the research of hypertension .

HY-W777156

Carazolol-d6 hydrochloride
Carazolol-d₆ (hydrochloride) is deuterium labeled Carazolol hydrochloride (HY-W517264). Carazolol hydrochloride is a highly potent antagonist of *β₁/β₂ adrenoceptor. Carazolol hydrochloride is also a potent, selective β₃-adrenoceptor* agonist. Carazolol hydrochloride can be used in the research of hypertension .

HY-14302S1

Salmeterol-d5
Salmeterol-d5 is a deuterated labeled Salmeterol . Salmeterol (GR33343X) is a potent and selective human β2 adrenoceptor agonist. Salmeterol shows potent stimulation of cAMP accumulation in CHO cells expressing human β2, β1 and β3 adrenoceptors with pEC₅₀s of 9.6, 6.1, and 5.9, respectively ^[2].

HY-17453S

Salmeterol-d3 xinafoate
Salmeterol-d₃ (xinafoate) is the deuterium labeled Salmeterol xinafoate. Salmeterol (GR 33343X) xinafoate is a potent and selective human β2 adrenoceptor agonist. Salmeterol shows potent stimulation of cAMP accumulation in CHO cells expressing human β2, β1 and β3 adrenoceptors with pEC₅₀s of 9.6, 6.1, and 5.9, respectively .

HY-17453S1

Salmeterol-13C6 xinafoate
Salmeterol- ¹³C₆ (xinafoate) is the ¹³C₆ labeled Salmeterol (xinafoate). Salmeterol (GR 33343X) xinafoate is a potent and selective human β2 adrenoceptor agonist. Salmeterol shows potent stimulation of cAMP accumulation in CHO cells expressing human β2, β1 and β3 adrenoceptors with pEC50s of 9.6, 6.1, and 5.9, respectively.

HY-B0374S1

Moxonidine-d7

Moxonidine-d₇ is deuterated labeled Moxonidine (HY-B0374). Moxonidine (BDF5895) is an orally active imidazoline type 1 receptor (I₁-R) agonist. Moxonidine activates imidazoline I₁ receptors and α₂ adrenoceptors, affecting oxidized low-density lipoprotein uptake. Moxonidine reduces atherosclerotic lesions and lowers blood pressure. Moxonidine can be used in the study of hypertension, heart failure, and atherosclerosis ^[2] .

HY-B0374AS

Moxonidine-13C,d3 hydrochloride

Moxonidine- ¹³C,d₃ hydrochloride is ¹³C and deuterated labeled Moxonidine hydrochloride (HY-B0374A). Moxonidine (BDF5895) is an orally active imidazoline type 1 receptor (I₁-R) agonist. Moxonidine activates imidazoline I₁ receptors and α₂ adrenoceptors, affecting oxidized low-density lipoprotein uptake. Moxonidine reduces atherosclerotic lesions and lowers blood pressure. Moxonidine can be used in the study of hypertension, heart failure, and atherosclerosis ^[2] .

HY-B0374S2

Moxonidine-d3

Moxonidine-d₃ (BDF5895-d₃) is deuterium labeled Moxonidine (HY-B0374). Moxonidine (BDF5895) is an orally active imidazoline type 1 receptor (I₁-R) agonist. Moxonidine activates imidazoline I₁ receptors and α₂ adrenoceptors, affecting oxidized low-density lipoprotein uptake. Moxonidine reduces atherosclerotic lesions and lowers blood pressure. Moxonidine can be used in the study of hypertension, heart failure, and atherosclerosis ^[2] .

HY-15746S

(rac)-Dobutamine-d4 hydrochloride

(rac)-Dobutamine-d₄ (hydrochloride) is a labelled racemic Dobutamine hydrochloride. Dobutamine hydrochloride is a synthetic catecholamine that acts on α1-AR, β1-AR, β2-AR (α-1, β-1 andβ-2 adrenoceptors). Dobutamine hydrochloride is a selective β1-AR agonist, relatively weak activity at α1-AR and β2-AR. Dobutamine hydrochloride can increase cardiac output and correct hypoperfusion ^[2] .

HY-15746S1

(rac)-Dobutamine-d6 hydrochloride

(rac)-Dobutamine-d₆ (hydrochloride) is a labelled racemic Dobutamine hydrochloride. Dobutamine hydrochloride is a synthetic catecholamine that acts on α1-AR, β1-AR, β2-AR (α-1, β-1 andβ-2 adrenoceptors). Dobutamine hydrochloride is a selective β1-AR agonist, relatively weak activity at α1-AR and β2-AR. Dobutamine hydrochloride can increase cardiac output and correct hypoperfusion ^[2] .

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