1 Result for "

2962941-25-7

" in MedChemExpress (MCE) Product Catalog:
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1 Results for "2962941-25-7" in MCE Product Catalog:

Cat. No.: HY-163527
CAS No.: 2962941-25-7
Target:  

FGFR

Research Areas:  

Cancer

FGFR-IN-13 (compound III-30) is an irreversible covalent fibroblast growth factor receptor (FGFR) inhibitor. FGFR-IN-13 regulates endogenous FGFR1(IC50=0.20±0.02 nM) and FGFR4(IC50=0.40±0.03 nM) mediated signaling pathways by inhibiting the expression of key proteins. FGFR-IN-13 inhibits total-PARP and Bcl-2 protein expressions, and promote Cleaved-PARP and Bax protein expressions in a dose-dependent manner. FGFR-IN-13 has significant antitumor activity and oral activity .
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