3 Results for "

ABBV-400 Antibody

" in MedChemExpress (MCE) Product Catalog:
Products (3)

3 Results for "ABBV-400 Antibody" in MCE Product Catalog:

Cat. No.: HY-P99391
CAS No.: 1781223-80-0
Synonyms: ABT-700; ABBV-400 Antibody

Target:  

c-Met/HGFR Apoptosis

Research Areas:  

Cancer

Telisotuzumab (ABT-700) is a bivalent humanized IgG1 anti-c-Met monoclonal antibody. Telisotuzumab binds cellular c-Met and disrupts its productive dimerization and activation induced by HGF or by the high density of c-Met on the cell surface independent of ligand. Telisotuzumab induces apoptosis. Telisotuzumab can be used for the study of cancers harboring amplified MET, such as gastric and lung cancers .
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Cat. No.: HY-171945
CAS No.: 2850366-99-1
Synonyms: ABBV-400; Temab-A
Telisotuzumab Adizutecan (ABBV-400) is an anti-c-Met antibody-drug conjugate (ADC). Telisotuzumab Adizutecan is composed of the humanized anti-c-Met antibody Telisotuzumab (HY-P99391) and the topoisomerase 1 inhibitor (7-MAD-MDCPT) (HY-132162). Telisotuzumab Adizutecan exhibits significant anti-tumor activity against advanced solid tumors such as colorectal cancer, gastric cancer, and non-small cell lung cancer .
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Cat. No.: HY-P99391B
CAS No.: 1781223-80-0
Synonyms: ABT-700 (WT IgG1); ABBV-400 Antibody (WT IgG1)
Target:  

c-Met/HGFR

Research Areas:  

Cancer

Telisotuzumab (WT IgG1) is a monoclonal antibody that retains the natural wild-type IgG1 Fc structure without engineering modification. Telisotuzumab (HY-P99391) is a humanized IgG1 anti-c-Met monoclonal antibody whose Fc hinge region has been engineered to introduce additional cysteine ​​coupling sites for targeted drug conjugation .
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