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Results for "

ACLY-IN-3

" in MedChemExpress (MCE) Product Catalog:

9

Inhibitors & Agonists

1

Fluorescent Dyes

1

Peptides

2

Click Chemistry

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-P10925A
    (Z)-Zolucatetide

    (Z)-FOG-001; I-67

    		 β-catenin Cancer
    (Z)-Zolucatetide (I-67) is a β-catenin inhibitor with IC50 ≤50 nM. (Z)-Zolucatetide's sequence is Ac-PL3-Asp-Npg-B5-Asp-3COOHF-Aib-Ala-Phe-Lys3-PyrS2-3Thi-BztA-GlnR3-Ala-NH2. (Z)-Zolucatetide can be used for cancer research .
    (Z)-Zolucatetide
  • HY-182750
    ACLY-IN-3

    		ATP Citrate Lyase Inflammation/Immunology
    ACLY-IN-3 is an ATP-citrate lyase (ACLY) inhibitor with an IC50 of 0.036 μM and a target Kd of 0.54 μM. ACLY-IN-3 interacts with the allosteric binding site of ACLY to inhibit its activity. ACLY-IN-3 exhibits excellent lipid-lowering effects and alleviates hepatic inflammation and liver fibrosis. ACLY-IN-3 can be used for the research of metabolic dysfunction-associated steatohepatitis .
    ACLY-IN-3
  • HY-175589
    XSJ81

    		Topoisomerase Apoptosis Bcl-2 Family Cancer
    XSJ81 is an orally active anti-cancer agent. XSJ81 significantly inhibits the proliferation of ampullary carcinoma (AC) DPC-X3 cells with an IC50 of 0.655 μM. XSJ81 inhibits the colony formation, arrests cell cycle at the G2/M phase and inhibits the migration in DPC-X3 cells. XSJ81 induces DNA damage and apoptosis in DPC-X3 cells. XSJ81 demonstrates significant anti-tumor efficacy in mice bearing DPC-X3 xenografts. XSJ81 can be used for the study of ampullary carcinoma .
    XSJ81
  • HY-178485
    SJY26

    		PI3K HDAC Akt Histone Methyltransferase Cancer
    SJY26 is a PI3K/HDAC dual-target inhibitor with IC50s of 0.59 nM (PI3Kα and PI3Kδ), 2.02 nM (PI3Kγ), 12.69 nM (PI3Kβ) and 114 nM (HDAC1). SJY26 exhibits potent broad-spectrum anti-proliferative activity, and is particularly sensitive to Jurkat and PC9R cells. SJY26 inhibited the migration of PC9R cells, arrested the cell cycle and induced cell apoptosis. SJY26 reduces AKT phosphorylation, and decreases histone H3 deacetylation (Ac-H3). SJY26 can be used for the studies of non-small cell lung cancer and leukemia .
    SJY26
  • HY-D2989
    BG-NH2-Ac-N3

    SNAP-NH2-Ac-N3

    		 Biochemical Assay Reagents Others
    BG-NH2-Ac-N3 (SNAP-NH2-Ac-N3) is a nitrogen-containing SNAP tag with a nitro group. BG-NH2-Ac-N3 can be used for click chemistry labeling .
    BG-NH2-Ac-N3
  • HY-141077
    N-(Ac-PEG3)-N'-(azide-PEG3)-Cy7 chloride

    		PROTAC Linkers Cancer
    N-(Ac-PEG3)-N'-(azide-PEG3)-Cy7 (chloride) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs . N-(Ac-PEG3)-N'-(azide-PEG3)-Cy7 (chloride) is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
    N-(Ac-PEG3)-N'-(azide-PEG3)-Cy7 chloride
  • HY-170841
    HDAC3/BRD4-IN-1

    		HDAC Epigenetic Reader Domain Cancer
    HDAC3/BRD4-IN-1 (compound 26n) is an inhibitor of HDAC3/BRD4 with an IC50 of 8 nM for HDAC3 (IC50s are 220 nM and 120 nM for HDAC1 and HDAC2, respectively). HDAC3/BRD4-IN-1 has anti-tumor and anti-proliferative effects by upregulating Ac-H3 and downregulating c-Myc. The half-life of HDAC3/BRD4-IN-1 in human liver microsomes is 29.36 min .
    HDAC3/BRD4-IN-1
  • HY-120278
    4-Ethoxyquinazoline

    		Endogenous Metabolite Others
    4-Ethoxyquinazoline is a selective small molecule activator of bacterial glycoside hydrolases (AC50=3.5 mM) .
    4-Ethoxyquinazoline
  • HY-181024
    PROTAC HDAC8 Degrader-4

    		PROTACs HDAC Cancer
    PROTAC HDAC8 Degrader-3 (Compound BP6) is an efficient, selective and low-toxicity HDAC8 PROTAC degrader with a DC50 of 80 nM. PROTAC HDAC8 Degrader-3 exhibits IC50 of PROTAC for HDAC8 and CRBN of 0.26 and 30 μM respectively. PROTAC HDAC8 Degrader-3 increases the level of Ac-SMC3, stabilizes p53 and sensitizes targeted reagents (such as Idasanutlin (HY-15676)), demonstrating its great potential in combination therapy .
    PROTAC HDAC8 Degrader-4

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