1 Result for "

AKN-028 TFA

" in MedChemExpress (MCE) Product Catalog:
Products (1)

1 Results for "AKN-028 TFA" in MCE Product Catalog:

Cat. No.: HY-118304A
CAS No.: 1175017-91-0
Target:  

FLT3 Apoptosis Caspase

Research Areas:  

Cancer

AKN-028 TFA, a novel tyrosine kinase (TK) inhibitor, is a potent, orally active FMS-like receptor tyrosine kinase 3 (FLT3) inhibitor with an IC50 value of 6 nM. AKN-028 TFA inhibits FLT3 autophosphorylation. AKN-028 TFA induces dose-dependent cytotoxic response (mean IC50=1 μM). AKN-028 TFA induces apoptosisby activation of caspase 3. AKN-028 TFA can be used in research of acute myeloid leukemia (AML) .
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