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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
173 Results for "
ATP-dependent
" in MedChemExpress (MCE) Product Catalog:
Products (173)
173 Results for "ATP-dependent" in MCE Product Catalog:
14
14 Publications Verification
Synonyms: LY333531
Target:
Forschungsgebiete:
Ruboxistaurin (LY333531) is an orally active, selective PKC beta inhibitor (Ki=2 nM). Ruboxistaurin exhibits ATP dependent competitive inhibition of PKC beta I with an IC50 of 4.7 nM. Ruboxistaurin inhibits PKC beta II with an IC50 of 5.9 nM .
14
14 Publications Verification
Synonyms: LY333531 hydrochloride
Target:
Forschungsgebiete:
Ruboxistaurin (LY333531) hydrochloride is an orally active, selective PKC beta inhibitor (Ki=2 nM). Ruboxistaurin hydrochloride exhibits ATP dependent competitive inhibition of PKC beta I with an IC50 of 4.7 nM. Ruboxistaurin hydrochloride inhibits PKC beta II with an IC50 of 5.9 nM .
10
10 Cited Publications
Forschungsgebiete:
TAS4464 is a long-acting, highly selective covalent inhibitor targeting NEDD8-activating enzyme (NAE) (IC50=0.955 nM), and also inhibits CAII with an IC50 of 0.73 μM, which is less potent than MLN4924 (HY-70062). The IC50 values of TAS4464 against other E1 enzymes UAE and SAE are 449 nM and 1280 nM, respectively. TAS4464 targets NEDD8 in an ATP-dependent manner to inhibit NAE, blocks the neddylation pathway, causes accumulation of CRL ubiquitin ligase substrates (such as CDT1, p27, phosphorylated IκBα), and further induces tumor cell apoptosis. TAS4464 exhibits antiproliferative and cytotoxic effects, and has broad-spectrum antitumor activity against various hematologic and solid tumor cell lines as well as patient-derived tumor cells. TAS4464 has a wide selcetive window, without obvious toxicity. TAS4464 can be used in the research of hematologic malignancies (leukemia, lymphoma, multiple myeloma, etc.) and solid tumors (small cell lung cancer, colorectal cancer, sarcoma, endometrial cancer, ovarian cancer, etc.) .
10
10 Cited Publications
Forschungsgebiete:
TAS4464 hydrochloride is a long-acting, highly selective covalent inhibitor targeting NEDD8-activating enzyme (NAE) (IC50=0.955 nM), and also inhibits CAII with an IC50 of 0.73 μM, which is less potent than MLN4924 (HY-70062). The IC50 values of TAS4464 hydrochloride against other E1 enzymes UAE and SAE are 449 nM and 1280 nM, respectively. TAS4464 hydrochloride targets NEDD8 in an ATP-dependent manner to inhibit NAE, blocks the neddylation pathway, causes accumulation of CRL ubiquitin ligase substrates (such as CDT1, p27, phosphorylated IκBα), and further induces tumor cell apoptosis. TAS4464 hydrochloride exhibits antiproliferative and cytotoxic effects, and has broad-spectrum antitumor activity against various hematologic and solid tumor cell lines as well as patient-derived tumor cells. TAS4464 hydrochloride has a wide therapeutic window, without obvious toxicity. TAS4464 hydrochloride can be used in the research of hematologic malignancies (leukemia, lymphoma, multiple myeloma, etc.) and solid tumors (small cell lung cancer, colorectal cancer, sarcoma, endometrial cancer, ovarian cancer, etc.) .
8
8 Cited Publications
Art. -Nr.: HY-D1297
CAS. Nr.: 730931-46-1
8
8 Cited Publications
Synonyms: AEGR-733 mesylate; BMS-201038 mesylate
Forschungsgebiete:
Cardiovascular Disease Neurological Disease Metabolic Disease Cancer
Lomitapide (AEGR-733; BMS-201038) mesylate is an orally active microsomal triglyceride transfer protein (MTP) inhibitor and a selective mTORC1 inhibitor with lipid-lowering activity and BBB permeability. Lomitapide mesylate significantly reduces plasma LDL levels by blocking the assembly and secretion of very-low-density lipoprotein (VLDL). Lomitapide mesylate inhibits mTORC1 in an ATP-dependent manner, thereby inducing AMPK-independent autophagic cell death and suppressing cancer cell growth and apoptosis. Lomitapide mesylate also enhances tumor infiltration of CD8 + T cells. In addition, Lomitapide mesylate inhibits HDAC, improves endothelial function, effectively alleviates vascular inflammation and oxidative stress, and exerts neuroprotective effects in a cerebral ischemia/reperfusion injury model. Lomitapide mesylate can be used in research on related diseases such as colorectal cancer, breast cancer, melanoma, ischemic stroke, and familial hypercholesterolemia .
5
5 Cited Publications
Art. -Nr.: HY-D1431
5
Category:
4
4 Cited Publications
Synonyms: 5'-Uridylic acid
4
4 Cited Publications
Art. -Nr.: HY-W013175
CAS. Nr.: 3387-36-8
Synonyms: 5'-Uridylic acid disodium salt
3
3 Cited Publications
Synonyms: Adenylyl-imidodiphosphate tetralithium
Target:
Forschungsgebiete:
AMP-PNP (Adenylyl-imidodiphosphate) tetralithium is a non-hydrolyzable ATP analog. AMP-PNP tetralithium binds to ATP binding sites competely but is not hydrolyzed by enzymes, providing stable experimental conditions for studying ATP-dependent processes. AMP-PNP tetralithium can also be used to study enzyme activity, kinase regulation, DNA/RNA metabolism, ion channel function, and protein complex assembly .
3
3 Cited Publications
Art. -Nr.: HY-130777A
Reinheit: ≥94.0%
Synonyms: Adenylyl imidodiphosphate lithium hydrate
1
1 Cited Publications
Art. -Nr.: HY-175328
Target:
Forschungsgebiete:
LIBX-A403 is a potent, selective and reversible ACSL4 inhibitor with a human IC50 of 0.049 μM and a Kd of 0.29 μM. LIBX-A403 binds in the ACSL4 fatty acid pocket in an ATP-dependent manner. LIBX-A403 prevents cell ferroptosis. LIBX-A403 can be used for the researches of cancer and parkinson's disease .
1
1 Cited Publications
Target:
Forschungsgebiete:
DHX9-IN-1 is an inhibitor of ATP-dependent RNA helicase A (DHX9). Its EC50 value is 1.41 μM. DHX9-IN-1 has anti-tumor activity and can be used in colorectal cancer research .
1
1 Cited Publications
Art. -Nr.: HY-P702583
Reinheit: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: DDX5; DEAD (Asp-Glu-Ala-Asp) Box Helicase 5; Prev. G17P1; Putative ATP-dependent RNA Helicase DDX5; Prev. HLR1; ATP-dependent RNA Helicase DDX5; Probable ATP-dependent RNA Helicase DDX5; RNA Helicase; DEAD Box Protein 5; DEAD Box-5; P68; HUMP68; DEAD/H (A
Species:
Human
Source:
E. coli
1
1 Cited Publications
Art. -Nr.: HY-P703175
Reinheit: ≥ 85%, as determined by reducing SDS-PAGE.
Synonyms: ABCB1; P-170; Prev. PGY1; ATP-dependent Translocase ABCB1; Prev. MDR1; Phospholipid Transporter ABCB1; Prev. CLCS; Colchicin Sensitivity; Multidrug Resistance Protein 1; ATP-Binding Cassette Sub-Family B Member 1; ATP-Binding Cassette, Sub-Family B (MDR/T
Species:
Human
Source:
HEK293
1
1 Cited Publications
Art. -Nr.: HY-D0194
CAS. Nr.: 111843-78-8
Target:
Forschungsgebiete:
5 (6)-Carboxy-2',7'-dichlorofluorescein is a fluorescent probe substrate that acts on MRP1 and MRP3/Mrp3, passively diffuses across cell membranes, and is actively effluxed by MRP1 in MRP1-positive cells. 5 (6)-Carboxy-2',7'-dichlorofluorescein is transported across membranes in an ATP-dependent manner, but does not stimulate ATPase activity .
1
1 Cited Publications
Art. -Nr.: HY-P703112
Reinheit: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: DHX9; ATP-dependent RNA Helicase A; Prev. DDX9; NDH II; Prev. LKP; NDH2; Nuclear DNA Helicase II; DEAH (Asp-Glu-Ala-His) Box Polypeptide 9; RNA Helicase A; DEAH-Box Helicase 9; Leukophysin; RNA Helicase; RHA; MRD75; DEAD/H (Asp-Glu-Ala-Asp/His) Box Polype
Species:
Human
Source:
Sf9 insect cells
Art. -Nr.: HY-B0501
CAS. Nr.: 119478-55-6
Synonyms: CP 76136-27
Target:
Forschungsgebiete:
Danofloxacin mesylate (CP 76136-27) is a fluoroquinolone used as a veterinary drug. Danofloxacin mesylate has a broad spectrum of bactericidal activity, mainly inhibiting the DNA cycloenzyme of the bacteria. In addition, Danofloxacin mesylate is a substrate for ATP-dependent efflux transporters (P-gp and MRP2) .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
