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AngiotensinII (AngiotensinII) is a vasoconstrictor and a major bioactive peptide of the renin/angiotensin system. AngiotensinII human plays a central role in regulating human blood pressure, which is mainly mediated by interactions between AngiotensinII and the G-protein-coupled receptors (GPCRs) AngiotensinIItype 1 receptor (AT1R) and AngiotensinIItype 2receptor (AT2R). AngiotensinII human stimulates sympathetic nervous stimulation, increases aldosterone biosynthesis and renal actions. AngiotensinII human induces growth of vascular smooth muscle cells, increases collagen type I and III synthesis in fibroblasts, leading to thickening of the vascular wall and myocardium, and fibrosis. AngiotensinII human also induces apoptosis. AngiotensinII induces capillary formation from endothelial cells via the LOX-1 dependent redox-sensitive pathway .
AngiotensinII human (AngiotensinII) acetate is a vasoconstrictor and a major bioactive peptide of the renin/angiotensin system. AngiotensinII human acetate plays a central role in regulating human blood pressure, which is mainly mediated by interactions between AngiotensinII and the G-protein-coupled receptors (GPCRs) AngiotensinIItype 1 receptor (AT1R) and AngiotensinIItype 2receptor (AT2R). AngiotensinII human acetate stimulates sympathetic nervous stimulation, increases aldosterone biosynthesis and renal actions. AngiotensinII human acetate induces growth of vascular smooth muscle cells, increases collagen type I and III synthesis in fibroblasts, leading to thickening of the vascular wall and myocardium, and fibrosis. AngiotensinII human acetate also induces apoptosis. AngiotensinII human acetate induces capillary formation from endothelial cells via the LOX-1 dependent redox-sensitive pathway .
Apelin-13 is an endogenous ligand for the G-protein coupled receptorangiotensinII protein J (APJ), activating this G protein-coupled receptor with an EC 50 value of 0.37 nM. Apelin-13 is widely distributed in the central and peripheral nervous systems. Apelin-13 has vasodilatory and antihypertensive effects. Apelin-13 also can be used for researching type 2 diabetes and metabolic syndrome .
Apelin-13 TFA is an endogenous ligand for the G-protein coupled receptorangiotensinII protein J (APJ), activating this G protein-coupled receptor with an EC 50 value of 0.37 nM. Apelin-13 TFA has vasodilatory and antihypertensive effects. Apelin-13 TFA also can be used for researching type 2 diabetes and metabolic syndrome .
Buloxibutid (AT2 receptor agonist C21) is an orally active, selective angiotensinIItype 2receptor (AT2R) agonist, with a Ki value of 0.4 nM for porcine AT2R. Buloxibutid exerts effects such as vasodilation, anti-inflammation, anti-fibrosis (promoting the expression of collagenase MMP-13) and tissue repair mainly by activating the NO/cGMP pathway, inhibiting the pro-proliferative MAPK signaling, and suppressing the pro-fibrotic TGF-β/Smad pathway as well as the inflammatory NF-κB pathway. Buloxibutid can be used in research related to idiopathic pulmonary fibrosis, hypertension, and systemic sclerosis .
Olodanrigan (EMA401) is a highly selective, orally active, peripherally restricted angiotensinIItype 2receptor (AT2R) antagonist. It is under development as a neuropathic pain therapeutic agent. Olodanrigan (EMA401) analgesic action appears to involve inhibition of augmented AngII/AT2R induced p38 and p42/p44 MAPK activation, and hence inhibition of DRG neuron hyperexcitability and sprouting of DRG neurons .
AngiotensinII human (AngiotensinII) TFA is a vasoconstrictor and a major bioactive peptide of the renin/angiotensin system. AngiotensinII human TFA plays a central role in regulating human blood pressure, which is mainly mediated by interactions between AngiotensinII and the G-protein-coupled receptors (GPCRs) AngiotensinIItype 1 receptor (AT1R) and AngiotensinIItype 2receptor (AT2R). AngiotensinII human TFA stimulates sympathetic nervous stimulation, increases aldosterone biosynthesis and renal actions. AngiotensinII human TFA induces growth of vascular smooth muscle cells, increases collagen type I and III synthesis in fibroblasts, leading to thickening of the vascular wall and myocardium, and fibrosis. AngiotensinII human TFA also induces apoptosis. AngiotensinII human TFA induces capillary formation from endothelial cells via the LOX-1 dependent redox-sensitive pathway .
AngiotensinII human- 13C6, 15N TFA (Ang II- 13C6, 15N TFA) is 13C- and 15N-labeled AngiotensinII human (TFA) (HY-13948B). AngiotensinII human (AngiotensinII) TFA is a vasoconstrictor and a major bioactive peptide of the renin/angiotensin system. AngiotensinII human TFA plays a central role in regulating human blood pressure, which is mainly mediated by interactions between AngiotensinII and the G-protein-coupled receptors (GPCRs) AngiotensinIItype 1 receptor (AT1R) and AngiotensinIItype 2receptor (AT2R). AngiotensinII human TFA stimulates sympathetic nervous stimulation, increases aldosterone biosynthesis and renal actions .
Olodanrigan (EMA401) sodium is a highly selective, orally active, peripherally restricted angiotensinIItype 2receptor (AT2R) antagonist. Olodanrigan sodium is under development as a neuropathic pain therapeutic agent. Olodanrigan sodium analgesic action appears to involve inhibition of augmented AngII/AT2R induced p38 and p42/p44 MAPK activation, and hence inhibition of DRG neuron hyperexcitability and sprouting of DRG neurons .
Buloxibutid (AT2 receptor agonist C21) hydrochloride is an orally active, selective angiotensinIItype 2receptor (AT2R) agonist, with a Ki value of 0.4 nM for porcine AT2R. Buloxibutid hydrochloride exerts vasodilatory, anti-inflammatory, antifibrotic (promoting the expression of collagenase MMP-13) and tissue repair effects mainly by activating the NO/cGMP pathway, inhibiting the pro-proliferative MAPK signaling, and suppressing the pro-fibrotic TGF-β/Smad pathway and inflammatory NF-κB pathway. Buloxibutid hydrochloride can be used in research related to idiopathic pulmonary fibrosis, hypertension, systemic sclerosis and other conditions .
Buloxibutid (AT2 receptor agonist C21) (Standard) is the analytical standard of Buloxibutid (HY-100113). This product is intended for research and analytical applications. Buloxibutid is an orally active, selective angiotensinIItype 2receptor (AT2R) agonist, with a Ki value of 0.4 nM for porcine AT2R. Buloxibutid exerts effects such as vasodilation, anti-inflammation, anti-fibrosis (promoting the expression of collagenase MMP-13) and tissue repair mainly by activating the NO/cGMP pathway, inhibiting the pro-proliferative MAPK signaling, and suppressing the pro-fibrotic TGF-β/Smad pathway as well as the inflammatory NF-κB pathway. Buloxibutid can be used in research related to idiopathic pulmonary fibrosis, hypertension, and systemic sclerosis.
AngiotensinII (AngiotensinII) is a vasoconstrictor and a major bioactive peptide of the renin/angiotensin system. AngiotensinII human plays a central role in regulating human blood pressure, which is mainly mediated by interactions between AngiotensinII and the G-protein-coupled receptors (GPCRs) AngiotensinIItype 1 receptor (AT1R) and AngiotensinIItype 2receptor (AT2R). AngiotensinII human stimulates sympathetic nervous stimulation, increases aldosterone biosynthesis and renal actions. AngiotensinII human induces growth of vascular smooth muscle cells, increases collagen type I and III synthesis in fibroblasts, leading to thickening of the vascular wall and myocardium, and fibrosis. AngiotensinII human also induces apoptosis. AngiotensinII induces capillary formation from endothelial cells via the LOX-1 dependent redox-sensitive pathway .
AngiotensinII human (AngiotensinII) acetate is a vasoconstrictor and a major bioactive peptide of the renin/angiotensin system. AngiotensinII human acetate plays a central role in regulating human blood pressure, which is mainly mediated by interactions between AngiotensinII and the G-protein-coupled receptors (GPCRs) AngiotensinIItype 1 receptor (AT1R) and AngiotensinIItype 2receptor (AT2R). AngiotensinII human acetate stimulates sympathetic nervous stimulation, increases aldosterone biosynthesis and renal actions. AngiotensinII human acetate induces growth of vascular smooth muscle cells, increases collagen type I and III synthesis in fibroblasts, leading to thickening of the vascular wall and myocardium, and fibrosis. AngiotensinII human acetate also induces apoptosis. AngiotensinII human acetate induces capillary formation from endothelial cells via the LOX-1 dependent redox-sensitive pathway .
Apelin-13 is an endogenous ligand for the G-protein coupled receptorangiotensinII protein J (APJ), activating this G protein-coupled receptor with an EC 50 value of 0.37 nM. Apelin-13 is widely distributed in the central and peripheral nervous systems. Apelin-13 has vasodilatory and antihypertensive effects. Apelin-13 also can be used for researching type 2 diabetes and metabolic syndrome .
Apelin-13 TFA is an endogenous ligand for the G-protein coupled receptorangiotensinII protein J (APJ), activating this G protein-coupled receptor with an EC 50 value of 0.37 nM. Apelin-13 TFA has vasodilatory and antihypertensive effects. Apelin-13 TFA also can be used for researching type 2 diabetes and metabolic syndrome .
AngiotensinII human (AngiotensinII) TFA is a vasoconstrictor and a major bioactive peptide of the renin/angiotensin system. AngiotensinII human TFA plays a central role in regulating human blood pressure, which is mainly mediated by interactions between AngiotensinII and the G-protein-coupled receptors (GPCRs) AngiotensinIItype 1 receptor (AT1R) and AngiotensinIItype 2receptor (AT2R). AngiotensinII human TFA stimulates sympathetic nervous stimulation, increases aldosterone biosynthesis and renal actions. AngiotensinII human TFA induces growth of vascular smooth muscle cells, increases collagen type I and III synthesis in fibroblasts, leading to thickening of the vascular wall and myocardium, and fibrosis. AngiotensinII human TFA also induces apoptosis. AngiotensinII human TFA induces capillary formation from endothelial cells via the LOX-1 dependent redox-sensitive pathway .
AngiotensinII human- 13C6, 15N TFA (Ang II- 13C6, 15N TFA) is 13C- and 15N-labeled AngiotensinII human (TFA) (HY-13948B). AngiotensinII human (AngiotensinII) TFA is a vasoconstrictor and a major bioactive peptide of the renin/angiotensin system. AngiotensinII human TFA plays a central role in regulating human blood pressure, which is mainly mediated by interactions between AngiotensinII and the G-protein-coupled receptors (GPCRs) AngiotensinIItype 1 receptor (AT1R) and AngiotensinIItype 2receptor (AT2R). AngiotensinII human TFA stimulates sympathetic nervous stimulation, increases aldosterone biosynthesis and renal actions .
AngiotensinII (AngiotensinII) is a vasoconstrictor and a major bioactive peptide of the renin/angiotensin system. AngiotensinII human plays a central role in regulating human blood pressure, which is mainly mediated by interactions between AngiotensinII and the G-protein-coupled receptors (GPCRs) AngiotensinIItype 1 receptor (AT1R) and AngiotensinIItype 2receptor (AT2R). AngiotensinII human stimulates sympathetic nervous stimulation, increases aldosterone biosynthesis and renal actions. AngiotensinII human induces growth of vascular smooth muscle cells, increases collagen type I and III synthesis in fibroblasts, leading to thickening of the vascular wall and myocardium, and fibrosis. AngiotensinII human also induces apoptosis. AngiotensinII induces capillary formation from endothelial cells via the LOX-1 dependent redox-sensitive pathway .
AGTR2 Protein-VLP, Human (HEK293, His) is recommended for animal immunization, ELISA. It is not recommended for receptor-ligand interaction detection and SPR/BLI assay since there are other irrelevant membrane proteins of the host on the VLP envelope, and the receptor-ligand interaction will have strong background interference. High requirements for chips and experimental protocols are needed for SPR/BLI assays. If VLP control is required, it is recommended HY-P701236. Tags can only be detected under denaturing conditions.
AngiotensinII human- 13C6, 15N TFA (Ang II- 13C6, 15N TFA) is 13C- and 15N-labeled AngiotensinII human (TFA) (HY-13948B). AngiotensinII human (AngiotensinII) TFA is a vasoconstrictor and a major bioactive peptide of the renin/angiotensin system. AngiotensinII human TFA plays a central role in regulating human blood pressure, which is mainly mediated by interactions between AngiotensinII and the G-protein-coupled receptors (GPCRs) AngiotensinIItype 1 receptor (AT1R) and AngiotensinIItype 2receptor (AT2R). AngiotensinII human TFA stimulates sympathetic nervous stimulation, increases aldosterone biosynthesis and renal actions .
Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred
to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was
used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature.
Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred
to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was
used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature.
Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred
to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was
used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature.
Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred
to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was
MedchemExpress Validation 03
Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred
MedchemExpress Validation 04
Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred
to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was
used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature.
MedchemExpress Validation
Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred
to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was
used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature.
Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred
to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was
used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature.
MedchemExpress Validation
Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred
to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was
used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature.
MedchemExpress Validation
Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred
to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was
used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature.
MedchemExpress Validation
Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred
to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was
used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature.
MedchemExpress Validation
Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred
to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was
used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature.
MedchemExpress Validation
Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred
to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was
used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature.
MedchemExpress Validation
Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred
to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was
used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature.
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