Anti-CD3 antibody

Pathways Recommended:	Antibody-drug Conjugate/ADC Related

By Targets:	Apoptosis (1) CD3 (9) CTLA-4 (1) EGFR (1) Fluorescent Dye (1) IFNAR (1) Interleukin Related (1) MHC (1) PD-1/PD-L1 (2) ROR (1) TNF Receptor (2)
By Research Areas:	Cancer (5) Infection (1) Inflammation/Immunology (13)
Click Chemistry:	DBCO (1)

Targets Recommended: ADC Antibody Antibody-Drug Conjugates (ADCs) Antibody-Oligonucleotide Conjugates (AOCs) ADC Linker PROTAC-Linker Conjugates for PAC

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-P990864

Anti-CD3 Antibody (OKT-3)	CD3	Inflammation/Immunology
Anti-CD3 Antibody (OKT-3) is a kind of mouse IgG2a κ antibody inhibitor, targeting to human CD3. Anti-CD3 Antibody (OKT-3) decreases T cells. Anti-CD3 Antibody (OKT-3) can be used for the research of immunology, such as graft-versus-host disease .

HY-P99592

Solitomab AMG 110	CD3	Cancer
Solitomab (AMG 110) is a bispecific *anti-CD3* and anti-epithelial-cell-adhesion-molecule (EpCAM) antibody. Solitomab can be used for the research of primary uterine and ovarian carcinosarcoma cancer .

HY-P99909

Elranatamab PF-06863135; RN-613	TNF Receptor	Inflammation/Immunology
Elranatamab (PF-06863135) is an anti-CD3E/TNFRSF17 human IgG2κ monoclonal antibody . Recommend Isotype Controls: Human IgG2 kappa, Isotype Control (HY-P99002).

HY-P99332

Visilizumab Anti-Human CD3E Recombinant Antibody; HuM291	Apoptosis	Inflammation/Immunology Cancer
Visilizumab (Anti-Human CD3E Recombinant Antibody) is a humanized low-Fc receptor binding anti-CD3 monoclonal IgG2 antibody. Visilizumab can be used for ulcerative colitis and Crohn's disease research .

HY-P99199

Foralumab NI-0401	CD3	Inflammation/Immunology
Foralumab (NI-0401) is a potent, orally active human monoclonal antibody targeting the CD3. Foralumab modulates immune responses by human cells in NSG mice that were reconstituted with human hematopoietic stem cells .

HY-D2171

AF488 DBCO	Fluorescent Dye	Others
AF488 DBCO is a fluorescent dye and also a click chemistry reagent that can label azide-containing biomolecules. AF488 DBCO mediates the coupling reaction with azide-modified 2'-OMe RNA oligonucleotides. DBCO is a bioorthogonal partner of azides and enables covalent coupling without copper (Ex/Em = 470/520 nm) .

HY-P991209

Nebratamig GNC-035	ROR CD3 PD-1/PD-L1	Inflammation/Immunology Cancer
Nebratamig (GNC-035) is an anti-ROR1/anti-CD3/anti-PD-L1/anti-4-1BB tetra-specific antibody with potential immunostimulatory and antineoplastic activities .

HY-P991842

Anti-CD3 Antibody (UCHT-1)	CD3	Inflammation/Immunology
Anti-CD3 Antibody (UCHT-1) reacts with human CD3ε. Anti-CD3 Antibody (UCHT-1) can be used for the study of graft-versus-host disease (GVHD). Recommend Isotype Controls: Mouse IgG1 kappa, Isotype Control (HY-P99977) .

HY-P990714

Obertamig	CD3	Inflammation/Immunology
Obertamig is an engineered, humanized, anti-CD3E/HLA-G monoclonal antibody with humanized CH2-CH3 modifications and consists of half immunoglobulin IgG1 λ2 and a single-chain variable fragment (scFv) .

HY-P99837

Dafsolimab SPV-T3a	CD3	Infection
Dafsolimab (SPV-T3a) is a Mouse IgG2b monoclonal antibody (anti-CD3). Dafsolimab can induce cell death through modulation and activation of the CD3/T cell receptor complex. Dafsolimab can be used for the research of graft-versus-host disease (GVHD) .

HY-P990698

Umizortamig	PD-1/PD-L1 EGFR	Inflammation/Immunology
Umizortamig is an anti-CD3E/EGFR/TNFRSF9/PD-L1/CD3G monoclonal antibody .

HY-P991406

MK-1248	TNF Receptor	Cancer
MK-1248 is a human IgG4 monoclonal antibody (mAb) targeting TNFSF18. MK-1248 enhances the proliferative response of tumor-infiltrating lymphocytes to anti-CD3 stimulation and promotes the production of anti-tumor-associated regulatory cytokines. MK-1248 can be used in solid tumors research .

HY-P990692

Ciduvectamig JNJ-70218902; JNJ-902	CD3	Inflammation/Immunology
Ciduvectamig is an anti-CD3E/TMEFF2 human IgG4 κ monoclonal antibody . Recommend Isotype Controls: Human IgG4 (S228P) kappa, Isotype Control (HY-P99003).

HY-180609

TCR-IN-2	MHC Interleukin Related CD3 IFNAR	Inflammation/Immunology
TCR-IN-2 (Compound A-68) is a TCR inhibitor. TCR-IN-2 inhibits the release of IFNγ and IL-2. TCR-IN-2 inhibits the time-dependent phosphorylation of CD3ζ. TCR-IN-2 inhibits TCR-mediated T cell activation, both in response to anti-CD3 antibodies and in response to human cells with unmatched HLA .

HY-P991959

JMW-3B3	CTLA-4	Inflammation/Immunology Cancer
JMW-3B3 is a humanized IgG1λ monoclonal antibody targeting CTLA-4. JMW-3B3 selectively binds the unique C-terminal sequence of sCTLA-4 to block its immunoregulatory and immunosuppressive activity without cross-reacting with full-length CTLA-4 receptor. JMW-3B3 enhances cytokine profiles in PBMC cultures responding to lupus autoantigen-derived peptides. JMW-3B3 enhances IFN-γ production in anti-CD3 stimulated PBMC from melanoma patients at low anti-CD3 doses. JMW-3B3 can be used for the research of systemic lupus erythematosus and malignant melanoma.

Cat. No.	Product Name	Type

HY-D2171

AF488 DBCO	Fluorescent Dyes
AF488 DBCO is a fluorescent dye and also a click chemistry reagent that can label azide-containing biomolecules. AF488 DBCO mediates the coupling reaction with azide-modified 2'-OMe RNA oligonucleotides. DBCO is a bioorthogonal partner of azides and enables covalent coupling without copper (Ex/Em = 470/520 nm) .

Cat. No.	Product Name

HY-K0353

Human CD3/CD28 T Cell Activation Magnetic Beads 1 Publications Verification
MCE Human CD3/CD28 T Cell Activation Magnetic Beads are based on the two important co-stimulatory signals, without relying on feeder cells (antigen-presenting cells) or antigens, CD3 and CD28, without relying on feeder cells (antigen-presenting cells) or antigens, enabling simple and rapid T cell activation.

HY-K0354

Mouse CD3/CD28 T Cell Activation Magnetic Beads
MCE Mouse CD3/CD28 T Cell Activation Magnetic Beads are based on the two important co-stimulatory signals, without relying on feeder cells (antigen-presenting cells) or antigens, CD3 and CD28, without relying on feeder cells (antigen-presenting cells) or antigens, enabling simple and rapid T cell activation.

Cat. No.	Product Name	Target	Research Area	Image

HY-P990864

Anti-CD3 Antibody (OKT-3)	CD3	Inflammation/Immunology
Anti-CD3 Antibody (OKT-3) is a kind of mouse IgG2a κ antibody inhibitor, targeting to human CD3. Anti-CD3 Antibody (OKT-3) decreases T cells. Anti-CD3 Antibody (OKT-3) can be used for the research of immunology, such as graft-versus-host disease .

HY-P99592

Solitomab AMG 110	CD3	Cancer
Solitomab (AMG 110) is a bispecific *anti-CD3* and anti-epithelial-cell-adhesion-molecule (EpCAM) antibody. Solitomab can be used for the research of primary uterine and ovarian carcinosarcoma cancer .

HY-P99909

Elranatamab PF-06863135; RN-613	TNF Receptor	Inflammation/Immunology
Elranatamab (PF-06863135) is an anti-CD3E/TNFRSF17 human IgG2κ monoclonal antibody . Recommend Isotype Controls: Human IgG2 kappa, Isotype Control (HY-P99002).

HY-P99332

Visilizumab Anti-Human CD3E Recombinant Antibody; HuM291	Apoptosis	Inflammation/Immunology Cancer
Visilizumab (Anti-Human CD3E Recombinant Antibody) is a humanized low-Fc receptor binding anti-CD3 monoclonal IgG2 antibody. Visilizumab can be used for ulcerative colitis and Crohn's disease research .

HY-P99199

Foralumab NI-0401	CD3	Inflammation/Immunology
Foralumab (NI-0401) is a potent, orally active human monoclonal antibody targeting the CD3. Foralumab modulates immune responses by human cells in NSG mice that were reconstituted with human hematopoietic stem cells .

HY-P99418

Acapatamab AMG-160	Inhibitory Antibodies	Inflammation/Immunology
Acapatamab (AMG-160) is an anti-CD3E/FOLH1 monoclonal antibody .

HY-P99912

Emerfetamab AMG-673	Inhibitory Antibodies	Inflammation/Immunology
Emerfetamab is an anti-CD3E/CD33 monoclonal antibody .

HY-P991209

Nebratamig GNC-035	ROR CD3 PD-1/PD-L1	Inflammation/Immunology Cancer
Nebratamig (GNC-035) is an anti-ROR1/anti-CD3/anti-PD-L1/anti-4-1BB tetra-specific antibody with potential immunostimulatory and antineoplastic activities .

HY-P991842

Anti-CD3 Antibody (UCHT-1)	CD3	Inflammation/Immunology
Anti-CD3 Antibody (UCHT-1) reacts with human CD3ε. Anti-CD3 Antibody (UCHT-1) can be used for the study of graft-versus-host disease (GVHD). Recommend Isotype Controls: Mouse IgG1 kappa, Isotype Control (HY-P99977) .

HY-P990714

Obertamig	CD3	Inflammation/Immunology
Obertamig is an engineered, humanized, anti-CD3E/HLA-G monoclonal antibody with humanized CH2-CH3 modifications and consists of half immunoglobulin IgG1 λ2 and a single-chain variable fragment (scFv) .

HY-P99837

Dafsolimab SPV-T3a	CD3	Infection
Dafsolimab (SPV-T3a) is a Mouse IgG2b monoclonal antibody (anti-CD3). Dafsolimab can induce cell death through modulation and activation of the CD3/T cell receptor complex. Dafsolimab can be used for the research of graft-versus-host disease (GVHD) .

HY-P990698

Umizortamig	PD-1/PD-L1 EGFR	Inflammation/Immunology
Umizortamig is an anti-CD3E/EGFR/TNFRSF9/PD-L1/CD3G monoclonal antibody .

HY-P991406

MK-1248	TNF Receptor	Cancer
MK-1248 is a human IgG4 monoclonal antibody (mAb) targeting TNFSF18. MK-1248 enhances the proliferative response of tumor-infiltrating lymphocytes to anti-CD3 stimulation and promotes the production of anti-tumor-associated regulatory cytokines. MK-1248 can be used in solid tumors research .

HY-P990692

Ciduvectamig JNJ-70218902; JNJ-902	CD3	Inflammation/Immunology
Ciduvectamig is an anti-CD3E/TMEFF2 human IgG4 κ monoclonal antibody . Recommend Isotype Controls: Human IgG4 (S228P) kappa, Isotype Control (HY-P99003).

HY-P991959

JMW-3B3	CTLA-4	Inflammation/Immunology Cancer
JMW-3B3 is a humanized IgG1λ monoclonal antibody targeting CTLA-4. JMW-3B3 selectively binds the unique C-terminal sequence of sCTLA-4 to block its immunoregulatory and immunosuppressive activity without cross-reacting with full-length CTLA-4 receptor. JMW-3B3 enhances cytokine profiles in PBMC cultures responding to lupus autoantigen-derived peptides. JMW-3B3 enhances IFN-γ production in anti-CD3 stimulated PBMC from melanoma patients at low anti-CD3 doses. JMW-3B3 can be used for the research of systemic lupus erythematosus and malignant melanoma.

Cat. No.	Product Name		Classification

HY-D2171

AF488 DBCO		DBCO
AF488 DBCO is a fluorescent dye and also a click chemistry reagent that can label azide-containing biomolecules. AF488 DBCO mediates the coupling reaction with azide-modified 2'-OMe RNA oligonucleotides. DBCO is a bioorthogonal partner of azides and enables covalent coupling without copper (Ex/Em = 470/520 nm) .

MCE Japan Authorized Agent ナミキ商事株式会社コスモ・バイオ株式会社重松貿易株式会社
Salutation			Country or Region *
Applicant Name *			Organization Name *
Department *
Email Address *			Product Name *
Cat. No.			Requested quantity *
Phone Number *
Remarks

Inhibitors & Agonists

Fluorescent Dyes

MCE Kits

Inhibitory Antibodies

Click Chemistry