2. Immunology/Inflammation
  3. CD3
  4. Solitomab

Solitomab  (Synonyms: AMG 110; MT110)

Cat. No.: HY-P99592

Solitomab (AMG 110) is a bispecific anti-CD3 and anti-epithelial-cell-adhesion-molecule (EpCAM) antibody. Solitomab can be used for the research of primary uterine and ovarian carcinosarcoma cancer.

For research use only. We do not sell to patients.

Solitomab Chemical Structure

Solitomab Chemical Structure

CAS No. : 1005198-65-1

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Description

Solitomab (AMG 110) is a bispecific anti-CD3 and anti-epithelial-cell-adhesion-molecule (EpCAM) antibody. Solitomab can be used for the research of primary uterine and ovarian carcinosarcoma cancer[1][2].

In Vitro

Solitomab (1 μg/mL; 4 hours) shows cytotoxicity to EpCAM-positive cell lines and increases the sensibility of EpCAM positive carcinosarcomas (CS) cells to T-cell-cytotoxicity[1].
Solitomab (7 days) increases the expression level of CD25 and HLA-DR protein (T-cell activation markers) on CD8+ and CD4+ T cells[1].
Solitomab (0-2.5 μg/mL; 4 hours) is cytotoxic to ovarian carcinoma cells and the 1 μg/mL dose shows the best tumor killing effects[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
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SMILES

[Solitomab]
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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Keywords:

Solitomab1005198-65-1AMG 110 MT110AMG110AMG-110MT110MT 110MT-110CD3Cluster of differentiation 3bispecificcancerantibodyovarianuterineInhibitorinhibitorinhibit

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