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Antiproliferative.

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Oligonucleotides

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-Y0479
    L-Lactic acid
    10+ Cited Publications

    (S)-2-Hydroxypropanoic acid

    		 Environmental Pollutants Antibiotic Endogenous Metabolite Bacterial Infection Cancer
    L-Lactic acid is a buildiing block which can be used as a precursor for the production of the bioplastic polymer poly-lactic acid. L-Lactic acid has antiproliferative activity .
    L-Lactic acid
  • HY-W040233
    L-Lactic acid sodium
    10+ Cited Publications

    (S)-2-Hydroxypropanoic acid sodium

    		 Environmental Pollutants Antibiotic Endogenous Metabolite Drug Intermediate Bacterial Infection Cancer
    L-lactate Sodium (Sodium (S)-2-hydroxypropanoate) is a buildiing block which can be used as a precursor for the production of the bioplastic polymer poly-lactic acid. L-Lactic acid Sodium has antiproliferative activity .
    L-Lactic acid sodium
  • HY-N0181
    Ergosterol
    3 Publications Verification

    		 Endogenous Metabolite Inflammation/Immunology
    Ergosterol is the primary sterol found in fungi, with antioxidative, anti-proliferative, and anti-inflammatory effects.
    Ergosterol
  • HY-N0180
    18β-Glycyrrhetinic acid
    10+ Cited Publications

    		 Endogenous Metabolite Inflammation/Immunology Cancer
    18β-Glycyrrhetinic acid is the major bioactive component of Glycyrrhiza uralensis and possesses anti-ulcerative, anti-inflammatory and antiproliferative properties.
    18β-Glycyrrhetinic acid
  • HY-148185
    T01-1

    KL610023

    		 ADC Payload Cancer
    T01-1 is an anticancer agent (camptothecin derivative) with good anti-proliferative activity .
    T01-1
  • HY-N1497
    Plumbagin
    3 Publications Verification

    2-Methyljuglone

    		 Others Cancer
    Plumbagin (2-Methyljuglone) is a naphthoquinone isolated from Plumbago zeylanica, exhibits anticancer and antiproliferative activities .
    Plumbagin
  • HY-16114
    BNC105
    1 Publications Verification

    		 Microtubule/Tubulin Cancer
    BNC105 is a tubulin polymerization inhibitor with potent antiproliferative and tumor vascular disrupting properties.
    BNC105
  • HY-128224
    Antiproliferative agent-13

    		Drug Intermediate Cancer
    Antiproliferative agent-13 (compound 16c) shows an antiproliferative activity against human A375 cells with an IC50 value of 32.7 nM. Antiproliferative agent-13 can be used for the research of cancer .
    Antiproliferative agent-13
  • HY-N12282
    Isovitexin 2′′-O-rhamnoside

    		Others Cancer
    Isovitexin 2′′-O-rhamnoside, a phenolic, has antioxidant and antiproliferative activities .
    Isovitexin 2′′-O-rhamnoside
  • HY-N0944
    (-)-Heraclenol

    		Others Cancer
    (-)-Heraclenol is a derivative of furocoumarin isolated from Ducrosia anethifolia. (-)-Heraclenol shows antiproliferative and cytotoxic activities on cancer cell lines .
    (-)-Heraclenol
  • HY-123656
    Antiproliferative agent-61

    		Apoptosis Cancer
    Antiproliferative agent-61 is a synthetic β-carlinyl chalcone with significant antiproliferative activity. Antiproliferative agent-61 showed significant effects in a range of solid tumor cell lines, with the most prominent effects in breast cancer. Antiproliferative agent-61 showed IC50 values of 2.25 and 3.29 μM in the human breast cancer MCF-7 cell line. Antiproliferative agent-61 significantly induced DNA fragmentation and apoptosis in breast cancer cells. Antiproliferative agent-61 inhibited the interaction of MDM2 with p53 and promoted the degradation of MDM2 .
    Antiproliferative agent-61
  • HY-164906
    TMX-2138

    		CDK PROTACs Cancer
    TMX-2138 is a CDKs PROTAC degrader, with IC50s of 8.7 nM, 10.9 nM, 7.0 nM and 25.7 nM for CDK1/cyclinB, CDK2/cyclinA, CDK5/p25 and CDK9/cyclinT1, respectively. TMX-2138 promotes ubiquitination and degradation of CDKs. TMX-2138 can be used for the research of ovarian cancer (Pink: CDKs ligand (HY-151071); Blue: E3 ligase CRBN ligand (HY-14658); Black: linker (HY-W008352)) .
    TMX-2138
  • HY-152090
    Antiproliferative agent-17

    		Bacterial Sirtuin Infection Cancer
    Antiproliferative agent-17 is an antiproliferative agent. Antiproliferative agent-17 inhibits Gram-positive bacteria and has anticancer activity .
    Antiproliferative agent-17
  • HY-176538
    Antiproliferative agent-72

    		HSP Cancer
    Antiproliferative agent-72 (Compound 10) is a Hsp90 inhibitor with a Kd of 11 nM. Antiproliferative agent-72 has antiproliferative activity with IC50s of 1.5  μM and 1.1 μM for HCT116 and NCI-N87 cells, respectively. Antiproliferative agent-72 can be used for cancers research .
    Antiproliferative agent-72
  • HY-W278944
    Antiproliferative agent-15

    		Drug Derivative Cancer
    Antiproliferative agent-15 is an thienopyrimidine derivated anticancer agent. Antiproliferative agent-15 shows antiproliferative activity against human colon (HCT116 and HCT15) and brain (LN-229 and GBM-10) cancer cell lines .
    Antiproliferative agent-15
  • HY-N15577
    Antiproliferative agent-69

    		Drug Derivative Cancer
    Antiproliferative agent-69 (Compound 1) is a prenylated kaempferol derivative found in the fresh bud’s fur of Platanus acerifolia. Antiproliferative agent-69 shows significant antiproliferative effects against human breast cancer cells (MCF-7) and human hepatocellular carcinoma cells (Hep-G2) with IC50 values of 38.2 μM and 39.5 μM, respectively. Antiproliferative agent-69 is promising for research of breast cancer and liver cancer .
    Antiproliferative agent-69
  • HY-148453
    Antiproliferative agent-16

    		Drug Derivative Cancer
    Antiproliferative agent-16 is an indolyl hydrazide-hydrazone compound with anticancer activity. Antiproliferative agent-16 exhibits specificity toward breast cancer cells (IC50 of 6.94 μM for MCF-7 cells) .
    Antiproliferative agent-16
  • HY-169100
    Antiproliferative agent-57

    		VEGFR PI3K Akt mTOR p38 MAPK HIF/HIF Prolyl-Hydroxylase Cancer
    Antiproliferative agent-57 (compound M2) is a tumor angiogenesis inhibitor. Antiproliferative agent-57 inhibits the secretion of VEGF in SiHa cells under hypoxic conditions (IC50=0.68 μM) without inducing cytotoxicity. Antiproliferative agent-57 can modulate the PI3K/AKT/mTOR and MAPK signaling pathways in tumor cells to inhibit the expression of HIF-1α and VEGF in tumor tissues .
    Antiproliferative agent-57
  • HY-P10902
    Lorutengitide

    		DNA/RNA Synthesis Cancer
    Lorutengitide is a transcriptional regulatory peptide, and exhibits antiproliferative efficacy .
    Lorutengitide
  • HY-N7338
    Yadanziolide C

    		Others Cancer
    Yadanziolide C is a quassinoid with antiproliferative and differentiation-inducing properties in promyelocytic HL-60 cells .
    Yadanziolide C
  • HY-176485
    Antiproliferative agent-70

    		Ferroptosis Mitophagy Reactive Oxygen Species (ROS) Cancer
    Antiproliferative agent-70 (compound 23) is a potent antiproliferative agent. Antiproliferative agent-70 shows antiproliferative activities and induces MMP depolarization. Antiproliferative agent-70 induces mitochondrial dysfunction. Antiproliferative agent-70 induces mitophagy and ferroptosis. Antiproliferative agent-70 increases the protein expression of PINK1, p-Parkin, p53 and p21. Antiproliferative agent-70 increases intracellular ROS levels. Antiproliferative agent-70 shows anticancer activity .
    Antiproliferative agent-70
  • HY-147776
    Antiproliferative agent-8

    		MDM-2/p53 Cancer
    Antiproliferative agent-8 (Compound 5a) is an anti-cancer agent. Antiproliferative against-8 has antiproliferative activity. Antiproliferative agent-8 significantly increases the P53 levels .
    Antiproliferative agent-8
  • HY-142085
    Antiproliferative agent-20

    		VEGFR Cancer
    Antiproliferative agent-20 is a potent and orally active anticancer agent. Antiproliferative agent-20 exhibits antiproliferative and anti-angiogenic activities .
    Antiproliferative agent-20
  • HY-161089
    Antiproliferative agent-45

    		Others Cancer
    Antiproliferative agent-45 (compound 9) is a prodrug. Antiproliferative agent-45 exhibits significant anti-proliferative effects for human pancreatic cells in hypoxia but fewer effects in normoxia. Antiproliferative agent-45 can be used for cancer research .
    Antiproliferative agent-45
  • HY-155380
    Antiproliferative agent-41

    		Others Others
    Antiproliferative agent-41 (compound 14) is a antiproliferative agent indanorine .
    Antiproliferative agent-41
  • HY-156777
    Antiproliferative agent-36

    		Drug Derivative Cancer
    Antiproliferative agent-36 (compound 8i) is a benzothiazolyl hydrazones derived compound with antiproliferative activity. Antiproliferative agent-36 has a broad-spectrum anticancer activity .
    Antiproliferative agent-36
  • HY-152091
    Antiproliferative agent-18

    		Fungal Infection Cancer
    Antiproliferative agent-18 (Compound 5k) is an anti-proliferative agent. Antiproliferative agent-18 also displays moderate anti-bacterial and anti-fungi activity .
    Antiproliferative agent-18
  • HY-162770
    Antiproliferative agent-55

    		Biochemical Assay Reagents Cancer
    Antiproliferative agent-55 (Compound 2d) is an anti-proliferative agent that can inhibit the growth of cancer cells. Antiproliferative agent-55 can be used in cancer research .
    Antiproliferative agent-55
  • HY-N8676
    Antiproliferative agent-29

    		Others Cancer
    Antiproliferative agent-29 (Compound 16) is a triterpenoid isolated from the seeds of Peganum harmala L. Antiproliferative agent-29 has antiproliferative activity and has potential for cancer research .
    Antiproliferative agent-29
  • HY-N8677
    Antiproliferative agent-28

    		Others Cancer
    Antiproliferative agent-28 (Compound 14) is a triterpenoid isolated from the seeds of Peganum harmala L. Antiproliferative agent-28 has antiproliferative activity and has potential for cancer research .
    Antiproliferative agent-28
  • HY-150968
    Antiproliferative agent-11

    		Apoptosis Cancer
    Antiproliferative agent-11 (compound 7) is an antiproliferative and selective Ruthenium(II)-Tris-pyrazolylmethane complex. Antiproliferative agent-11 shows antiproliferative activity towards MCF-7, HeLa, 518A2, HCT116 and RD with IC50s of 6, 10, 6.8, 6.7 and 6 μM, respectively. Antiproliferative agent-11 can be used for the research of cancer .
    Antiproliferative agent-11
  • HY-158016
    Antiproliferative agent-49

    		EGFR Apoptosis Cancer
    Antiproliferative agent-49 (Compound 5a) is a EGFR-TK inhibitor with an IC50 of 0.09 μM. Antiproliferative agent-49 is a anti-proliferative agent. Antiproliferative agent-49 displays good activities against HER3 and HER4 with IC50 values 0.18 and 0.37 µM. Antiproliferative agent-49 induces mitochondrial apoptotic pathway and increased accumulation of ROS .
    Antiproliferative agent-49
  • HY-155069
    Antiproliferative agent-27

    		Apoptosis Cancer
    Antiproliferative agent-27 (compound 11) is an antiproliferative agent that significantly reduces the number of tumor cell colonies and induces apoptosis. Antiproliferative agent-27 has the potential to be used in the study of cancer .
    Antiproliferative agent-27
  • HY-148265
    Antiproliferative agent-14

    		Microtubule/Tubulin Cancer
    Antiproliferative agent-14 (compound 3b) a potent tubulin polymerization inhibitor, with an IC50 of 3.41 μM. Antiproliferative agent-14 has excellent antiproliferative activity. Antiproliferative agent-14 possess the ability to arrest cells at G2/M phases of the cell cycle .
    Antiproliferative agent-14
  • HY-161824
    Antiproliferative agent-52

    		Drug Intermediate Cancer
    Antiproliferative agent-52 (Compound 4a) is an antiproliferative agent that exhibits significant antiproliferative activity against four human tumor cell lines (A549, A2780, SKOV3, HCC827), with IC50 values ranging from 5.83 to 8.63 nM. Antiproliferative agent-52 can be used in cancer research .
    Antiproliferative agent-52
  • HY-155402
    Antiproliferative agent-42

    		Caspase Apoptosis Others
    Antiproliferative agent-42 (compound 7m) is a dihydrodipyrrolo compound. Antiproliferative agent-42 showed antiproliferative activity against Panc-1 cell line with an IC50 value of 12.54 μM .
    Antiproliferative agent-42
  • HY-155127
    Antiproliferative agent-33

    		Fungal Cancer
    Antiproliferative agent-33 (Compound 2g) is an anti-proliferative, antifungal, and antibacterial agent. Antiproliferative agent-33 inhibits MDA-MB-231 cell proliferation (IC50: 16.38 μM). Antiproliferative agent-33 inhibits gram-negative bacteria growth, and inhibits S. faecalis with an MIC value of 8 μg/mL .
    Antiproliferative agent-33
  • HY-146354
    Antiproliferative agent-4

    		Apoptosis Reactive Oxygen Species (ROS) Cancer
    Antiproliferative agent-4 (compound 2y) has excellent anti-proliferative activity against certain cancer cell lines. Antiproliferative agent-4 reduces the mitochondrial membrane potential, and increases the apoptosis rate and the level of ROS on EC109. Antiproliferative agent-4 inhibits tumour growth in nude mice, with low toxicity .
    Antiproliferative agent-4
  • HY-146103
    Antiproliferative agent-7

    		Apoptosis Reactive Oxygen Species (ROS) Cancer
    Antiproliferative agent-7 (compound 8f) is a potent anti-proliferative agent. Antiproliferative agent-7 has antiproliferative activity against cancer cell lines MCF-7, MDA-MB-231, HCT-116 and FR-2 with IC50s of 3.5 μM, 15.54 μM, 30.43 μM and 34.8 μM, respectively. Antiproliferative agent-7 can increase ROS production and induce apoptosis .
    Antiproliferative agent-7
  • HY-155051
    Antiproliferative agent-25

    		Apoptosis Histone Methyltransferase Cancer
    Antiproliferative agent-25 (Compound 3s4) is a selective PRMT5 inhibitor (IC50: 0.11 μM). Antiproliferative agent-25 up-regulates hnRNP E1 protein level. Antiproliferative agent-25 forms H-bond interactions with SAM and E444 residue of PRMT5. Antiproliferative agent-25 has antiproliferative effects against A549 cells by inducing apoptosis and inhibiting cell migration. Antiproliferative agent-25 has high clearances with T1/2 of only 21.8 and 4.7 min in human and rat liver microsomes .
    Antiproliferative agent-25
  • HY-175174
    Antiproliferative agent-73

    		Glutaminase Cancer
    Antiproliferative agent-73 (Compound 7) is an antiproliferative agent. Antiproliferative agent-73 significantly inhibits proliferation of human cancer cells with excellent cytotoxicity. Antiproliferative agent-73 has potent anticancer activity with IC50s of 15.20, 18.18, 20.20 and 13.23  μM for HepG2, MCF-7, HCT-116 and WI38 cells, respectively. Antiproliferative agent-73 can be used for cancers research, such as breast, colorectal and liver cancer .
    Antiproliferative agent-73
  • HY-162078
    Antiproliferative agent-46

    		Casein Kinase Cancer
    Antiproliferative agent-46 (compound 5e) is an inhibitor of the casein kinase-2 enzyme (CK2) receptor. Antiproliferative agent-46 has a potent antiproliferative activity with an IC50 value of 5.75 μM on the U87 cell line .
    Antiproliferative agent-46
  • HY-152099
    Antiproliferative agent-19

    		Apoptosis Cancer
    Antiproliferative agent-19 (compound 4a) is an anti-cancer agent that exerts anti-proliferative effects on lung cancer cells by inducing apoptosis. antiproliferative agent-19 also induces cell cycle arrest in the G2/M phase .
    Antiproliferative agent-19
  • HY-155112
    Antiproliferative agent-30

    		Microtubule/Tubulin FLT3 Bcr-Abl Cancer
    Antiproliferative agent-30 (Compound 8g) inhibits tubulin assembly and inhibits FLT3 and Abl1. Antiproliferative agent-30 has vascular-disrupting activity. Antiproliferative agent-30 has broad antiproliferative activities against cancer cell lines (IC50s: 0.054 nM, 0.008 nM, 0.144 nM for HCT-116, K562, MV-4-11 cells respectively). Antiproliferative agent-30 also has anticancer effect against AML with FLT3-ITD-TKD mutation .
    Antiproliferative agent-30
  • HY-168102
    Antiproliferative agent-59

    		Microtubule/Tubulin Apoptosis Cancer
    Antiproliferative agent-59 (Compound 14u) is an inhibitor for tubulin polymerization. Antiproliferative agent-59 exhibits antiproliferative activities against cancer cells Huh7, SGC-7901, and MCF-7 with IC50 of 0.03, 0.18, and 0.13μM. Antiproliferative agent-59 arrests the cell cycle at G2/M phase and induces apoptosis in Huh7 cell. Antiproliferative agent-59 exhibits antitumor efficacy against liver cancer in Huh7 xenograft mouse models, without significant toxicity .
    Antiproliferative agent-59
  • HY-163381
    Antiproliferative agent-48

    		Drug Intermediate Cancer
    Antiproliferative agent-48 (compound PC-A1) shows selective antiproliferative activity against triple-negative breast cancer (TNBC) cells .
    Antiproliferative agent-48
  • HY-146390
    Antiproliferative agent-5

    		Autophagy Reactive Oxygen Species (ROS) Cancer
    Antiproliferative agent-5 (compound 4o) can significantly and irreversibly inhibit proliferation of gastric cancer cells. Antiproliferative agent-5 causes the G2/M phase arrest, and induces ROS accumulation and activation of autophagy. Antiproliferative agent-5 can be used for researching anticancer .
    Antiproliferative agent-5
  • HY-156183
    Antiproliferative agent-37

    		MDM-2/p53 ERK Cancer
    Antiproliferative agent-37 (compound 10J) shows anti-proliferative effect by arresting the cells at the G2/M phase of the cell cycle .
    Antiproliferative agent-37
  • HY-155055
    Antiproliferative agent-26

    		Reactive Oxygen Species (ROS) Cancer
    Antiproliferative agent-26 (compound 4g) is an antiproliferative agent with much broad range of activity targeting Leukemia, CNS, Melanoma, Renal and Breast (at the concentration of 10 μM). Antiproliferative agent-26 inhibits colony forming and arrests cell cycle at G1 phase/S phase at 5 μM and 25 μM, respectively .
    Antiproliferative agent-26
  • HY-152945
    Antiproliferative agent-22

    		NF-κB Cancer
    Antiproliferative agent-22 (compound 2) is an anticancer agent. Antiproliferative agent-22 shoes anti-proliferative activities against MCF-7, MDA-MB-231 and MDA-MB-468 cells with IC50 values of 6.2 μM, 3.3 μM and 3.3 μM, respectively .
    Antiproliferative agent-22

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