1 Result for "

Aurothiomalate disodium

" in MedChemExpress (MCE) Product Catalog:
Products (1)

1 Results for "Aurothiomalate disodium" in MCE Product Catalog:

Cat. No.: HY-W010270A
CAS No.: 74916-57-7
Target:  

PKC NF-κB TrxR

Research Areas:  

Inflammation/Immunology Cancer

Aurothiomalate disodium acts as an inhibitor of PKCI and TrxR1. Aurothiomalate disodium disrupts the PKCI-Par6-Rac1 signaling pathway, and also inhibits TrxR1 activity, TNFα-induced NF-κB activation, and the expression of pro-inflammatory genes. Aurothiomalate disodium blocks Kras-mediated BASC expansion and lung tumor growth, inhibits anchorage-independent growth and tumorigenicity of lung cancer cells, and suppresses neutrophil chemotaxis, phagocytosis, and leukocyte extravasation. Aurothiomalate disodium can be used in research related to rheumatoid arthritis and non-small cell lung cancer .
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