BHK

By Targets:	Amyloid-β (2) Apolipoprotein (2) Apoptosis (1) ATP-binding cassette (ABC) transporters (1) Biochemical Assay Reagents (1) Dengue Virus (1) Flavivirus (1) Fluorescent Dye (2) Glycosidase (1) Liposome (1) mGluR (1) PAK (1) Quinone Reductase (1) Ras (1) Reactive Oxygen Species (ROS) (1) Virus Protease (5)
By Research Areas:	Cancer (4) Cardiovascular Disease (1) Infection (6) Metabolic Disease (3) Neurological Disease (3)
Oligonucleotides:	Cationic Lipids (1)

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-23430

TES	Biochemical Assay Reagents	Others
TES is an excellent hydrogen ion buffer. TES has characteristics such as an appropriate dissociation constant, a low metal-binding constant, and high water solubility. TES can be used in the research of mammalian cell culture, viruses, and so on .

HY-P6306

CS-6253 1 Publications Verification	Apolipoprotein Amyloid-β	Neurological Disease Metabolic Disease
CS-6253 is an agonist of ABCA1. CS-6253 can regulate lipoprotein metabolism, promote high-density lipoprotein biogenesis, and cellular cholesterol efflux. CS-6253 also has certain neuroprotective effects and can clear Aβ from the brain. CS-6253 can be used for research on cholesterol metabolism and diseases such as Alzheimer’s disease .

HY-W590549

Dioleyldimethylammonium chloride DODAC	Liposome	Cancer
Dioleyldimethylammonium chloride (DODAC) is a positively charged lipid promoter with membrane-disrupting activity, which is often formulated into cationic liposomes with dioleoylphosphatidylethanolamine. Dioleyldimethylammonium chloride is used in gene transfection research; through electrostatic interactions, it effectively promotes the binding of programmable fusion vesicles to cells and induces membrane disruption. Dioleyldimethylammonium chloride is also applied in studies on L1210 leukemia and LS180 human colon cancer .

HY-121138

1,8-Dihydroxy-4,5-dinitroanthraquinone ARDP0006; DHDNE	Flavivirus Dengue Virus Virus Protease	Infection
1,8-Dihydroxy-4,5-dinitroanthraquinone (ARDP0006; DHDNE) is a potent inhibitor of serine proteinase NS2B/3, the dengue viral protein. 1,8-Dihydroxy-4,5-dinitroanthraquinone has intermolecular proteinase activity and viral inhibition ability with IC₅₀s of 432 μM and 4.2 μM, respectively. Meanwhile 1,8-Dihydroxy-4,5-dinitroanthraquinone inhibits NS2B/3 cleavage in BHK-21 cells at a dose ranging from 4.2 μM to 432 μM .

HY-122914

KRAS inhibitor-3 1 Publications Verification	Ras	Cancer
KRAS inhibitor-3 is an inhibitor of KRAS inhibitor. KRAS inhibitor-3 binds to WT and oncogenic KRAS mutants with high affinity (K_D: 0.28 μM for KRAS WT, 0.63 μM for KRAS G12C, 0.37 μM for KRAS G12D, 0.74 μM for KRAS Q61H). KRAS inhibitor-3 also disrupts interaction of KRAS with Raf .

HY-P6306A

CS-6253 TFA 1 Publications Verification	Apolipoprotein Amyloid-β	Neurological Disease Metabolic Disease
CS-6253 TFA is an agonist of ABCA1. CS-6253 TFA can regulate lipoprotein metabolism, promote high-density lipoprotein biogenesis, and cellular cholesterol efflux. CS-6253 TFA also has certain neuroprotective effects and can clear Aβ from the brain. CS-6253 TFA can be used for research on cholesterol metabolism and diseases such as Alzheimer’s disease .

HY-W674245

10-Hydroxyhexadecanoic acid	ATP-binding cassette (ABC) transporters	Cardiovascular Disease
10-Hydroxyhexadecanoic acid is a hydroxy fatty acid found in Camembert cheese. 10-Hydroxyhexadecanoic acid can promote cholesterol efflux from ABCA1 and ABCG1, preventing the accumulation of excess cholesterol in cells. 10-Hydroxyhexadecanoic acid can be used in anti-atherosclerosis research .

HY-P2624

st-Ht31	PAK	Metabolic Disease
st-Ht31 is a membrane-permeable peptide inhibitor of protein kinase A (PKA) anchoring. st-Ht31 induces robust cholesterol/phospholipid efflux. st-Ht31 completely reverses foam cell formation and restores the metabolic health of macrophage .

HY-139663

IHVR-17028	Glycosidase	Infection
IHVR-17028 is a potent and broad-spectrum antiviral agent. IHVR-17028 exhibits antiviral activity against BVDV, TCRV and DENV with EC₅₀ values of 0.4 μM, 0.26 μM, 0.3 μM, respectively. IHVR-17028 is a potent ER α-glucosidase I inhibitor with an IC₅₀ of 0.24 μM. IHVR-17028 can be used for infectious diseases research .

HY-148310

Flaviviruses-IN-2	Virus Protease	Infection
Flaviviruses-IN-2 (compound 78) is a potent flaviviruses inhibitor. Flaviviruses-IN-2 reduces the WNV (West Nile virus) protease activity, with inhibition of 56% .

HY-NP0144

Succinylated Wheat Germ Agglutinin (Fluorescein) WGA (Fluorescein)	Fluorescent Dye	Others
Succinylated Wheat Germ Agglutinin (Fluorescein) (WGA (Fluorescein)) is a fluorescent lectin that acts as a probe to specifically bind biomolecules. Succinylated Wheat Germ Agglutinin (Fluorescein) binds to cell surface glycoconjugates containing N-acetylglucosamine. Succinylated Wheat Germ Agglutinin (Fluorescein) is a selective agglutinating agent targeting specific red blood cells, thymocytes, splenocytes and lymphocytes. Succinylated Wheat Germ Agglutinin (Fluorescein) binds to fibroblasts and lymphocytes via dual binding sites in a temperature-dependent, saturable manner. Succinylated Wheat Germ Agglutinin (Fluorescein) can be used for quantitative studies of cell surface receptor glycoconjugates (Ex=495 nm, Em=515 nm) .

HY-136575

4-Hydroxy-2-methylbenzenesulfonic acid ammonium	Virus Protease	Infection
4-Hydroxy-2-methylbenzenesulfonic acid ammonium is an impurity of Policresulen. Policresulen is a potent NS2B/NS3 protease inhibitor with an IC₅₀ of 0.48 μg/mL. Policresulen effectively inhibits the replication of DENV2 virus in BHK-21 cells with an IC₅₀ of 4.99 μg/mL. Policresulen acted as a competitive inhibitor of the protease, and slightly affected the protease stability .

HY-136573

5-Hydroxytoluene-2,4-disulphonic acid diammonium	Virus Protease	Infection
5-Hydroxytoluene-2,4-disulphonic acid diammonium is an impurity of Policresulen. Policresulen is a potent NS2B/NS3 protease inhibitor with an IC₅₀ of 0.48 μg/mL. Policresulen effectively inhibits the replication of DENV2 virus in BHK-21 cells with an IC₅₀ of 4.99 μg/mL. Policresulen acted as a competitive inhibitor of the protease, and slightly affected the protease stability .

HY-18679

TC-N 22A	mGluR	Neurological Disease
TC-N 22A is a potent, selective, orally active and brain-permeable mGlu₄ PAM with an EC₅₀ of 9 nM in human mGlu₄-expressing BHK cells. TC-N 22A is less active (EC₅₀>10 μM) in agonist and PAM model at mGlu 1, 2, 3, 5, and 7 receptors. TC-N 22A has the potential for research of CNS disease in vivo .

HY-136574

2-Hydroxy-4-methylbenzenesulphonic acid ammonium	Virus Protease	Infection
2-Hydroxy-4-methylbenzenesulphonic acid ammonium is an impurity of Policresulen. Policresulen is a potent NS2B/NS3 protease inhibitor with an IC₅₀ of 0.48 μg/mL. Policresulen effectively inhibits the replication of DENV2 virus in BHK-21 cells with an IC₅₀ of 4.99 μg/mL. Policresulen acted as a competitive inhibitor of the protease, and slightly affected the protease stability .

HY-N14947

Pterulinic acid	Quinone Reductase	Cancer
Pterulinic acid is a coenzyme I: Coenzyme Q oxidoreductase inhibitor. he IC₅₀ (μg/mL) L1210 and HL60 of Pterulinic acid to mammalian cell lines are 50 and 20 respectively. HeLaS3 25; BHK is 100 .

HY-D1749

C6 NBD L-threo-ceramide	Fluorescent Dye	Others
C6 NBD L-threo-ceramide is a cell-permeable analog of ceramides that is tagged with a fluorescent group C6 nitrobenzoxadiazole (C6 NBD). It is rapidly transferred between liposomes, labels the Golgi apparatus, and is metabolized to C6 NBD sphingomyelin in BHK cells and V79 fibroblasts.

HY-163034

Antitumor photosensitizer-5	Apoptosis Reactive Oxygen Species (ROS)	Cancer
Antitumor photosensitizer-5 (Ru2) is a photosensitizer which effectively target tumor mitochondria with an IC₅₀ of 0.3 μM for phototoxicity to A549 cells. Under 460 nm light irradiation, antitumor photosensitizer-5 induces the generation of reactive oxygen species and NADH depletion, causes mitochondrial damage and activation of caspase-3, inducing apoptosis and suppressing cell migration. Antitumor photosensitizer-5 has the potential to prevent the growth of malignant tumors, therefore, shows the potential to be applied to photodynamic therapy .

Cat. No.	Product Name	Type

HY-D1749

C6 NBD L-threo-ceramide	Fluorescent Dye
C6 NBD L-threo-ceramide is a cell-permeable analog of ceramides that is tagged with a fluorescent group C6 nitrobenzoxadiazole (C6 NBD). It is rapidly transferred between liposomes, labels the Golgi apparatus, and is metabolized to C6 NBD sphingomyelin in BHK cells and V79 fibroblasts.

Cat. No.	Product Name	Type

HY-23430

TES	Biochemical Assay Reagents
TES is an excellent hydrogen ion buffer. TES has characteristics such as an appropriate dissociation constant, a low metal-binding constant, and high water solubility. TES can be used in the research of mammalian cell culture, viruses, and so on .

HY-NP0144

Succinylated Wheat Germ Agglutinin (Fluorescein) WGA (Fluorescein)	Biochemical Assay Reagents
Succinylated Wheat Germ Agglutinin (Fluorescein) (WGA (Fluorescein)) is a fluorescent lectin that acts as a probe to specifically bind biomolecules. Succinylated Wheat Germ Agglutinin (Fluorescein) binds to cell surface glycoconjugates containing N-acetylglucosamine. Succinylated Wheat Germ Agglutinin (Fluorescein) is a selective agglutinating agent targeting specific red blood cells, thymocytes, splenocytes and lymphocytes. Succinylated Wheat Germ Agglutinin (Fluorescein) binds to fibroblasts and lymphocytes via dual binding sites in a temperature-dependent, saturable manner. Succinylated Wheat Germ Agglutinin (Fluorescein) can be used for quantitative studies of cell surface receptor glycoconjugates (Ex=495 nm, Em=515 nm) .

Succinylated Wheat Germ Agglutinin (Fluorescein)

WGA (Fluorescein)

Biochemical Assay Reagents

Succinylated Wheat Germ Agglutinin (Fluorescein) (WGA (Fluorescein)) is a fluorescent lectin that acts as a probe to specifically bind biomolecules. Succinylated Wheat Germ Agglutinin (Fluorescein) binds to cell surface glycoconjugates containing N-acetylglucosamine. Succinylated Wheat Germ Agglutinin (Fluorescein) is a selective agglutinating agent targeting specific red blood cells, thymocytes, splenocytes and lymphocytes. Succinylated Wheat Germ Agglutinin (Fluorescein) binds to fibroblasts and lymphocytes via dual binding sites in a temperature-dependent, saturable manner. Succinylated Wheat Germ Agglutinin (Fluorescein) can be used for quantitative studies of cell surface receptor glycoconjugates (Ex=495 nm, Em=515 nm) .

Cat. No.	Product Name	Target	Research Area

HY-P6306

CS-6253 1 Publications Verification	Apolipoprotein Amyloid-β	Neurological Disease Metabolic Disease
CS-6253 is an agonist of ABCA1. CS-6253 can regulate lipoprotein metabolism, promote high-density lipoprotein biogenesis, and cellular cholesterol efflux. CS-6253 also has certain neuroprotective effects and can clear Aβ from the brain. CS-6253 can be used for research on cholesterol metabolism and diseases such as Alzheimer’s disease .

HY-P6306A

CS-6253 TFA 1 Publications Verification	Apolipoprotein Amyloid-β	Neurological Disease Metabolic Disease
CS-6253 TFA is an agonist of ABCA1. CS-6253 TFA can regulate lipoprotein metabolism, promote high-density lipoprotein biogenesis, and cellular cholesterol efflux. CS-6253 TFA also has certain neuroprotective effects and can clear Aβ from the brain. CS-6253 TFA can be used for research on cholesterol metabolism and diseases such as Alzheimer’s disease .

HY-P2624

st-Ht31	PAK	Metabolic Disease
st-Ht31 is a membrane-permeable peptide inhibitor of protein kinase A (PKA) anchoring. st-Ht31 induces robust cholesterol/phospholipid efflux. st-Ht31 completely reverses foam cell formation and restores the metabolic health of macrophage .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N14947

Pterulinic acid	Microorganisms Antibiotics Other Antibiotics Source Classification	Quinone Reductase
Pterulinic acid is a coenzyme I: Coenzyme Q oxidoreductase inhibitor. he IC₅₀ (μg/mL) L1210 and HL60 of Pterulinic acid to mammalian cell lines are 50 and 20 respectively. HeLaS3 25; BHK is 100 .

Cat. No.	Product Name		Classification

HY-W590549

Dioleyldimethylammonium chloride DODAC		Cationic Lipids
Dioleyldimethylammonium chloride (DODAC) is a positively charged lipid promoter with membrane-disrupting activity, which is often formulated into cationic liposomes with dioleoylphosphatidylethanolamine. Dioleyldimethylammonium chloride is used in gene transfection research; through electrostatic interactions, it effectively promotes the binding of programmable fusion vesicles to cells and induces membrane disruption. Dioleyldimethylammonium chloride is also applied in studies on L1210 leukemia and LS180 human colon cancer .

MCE Japan Authorized Agent ナミキ商事株式会社コスモ・バイオ株式会社重松貿易株式会社
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BHK

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