81-55-0
Chemical Structure
1,8-Dihydroxy-4,5-dinitroanthraquinone
Synonym(s): ARDP0006; DHDNE
- CAS No.: 81-55-0
- Formula:C14H6N2O8
- Molecular Weight:330.21
IUPAC Name: 1,8-dihydroxy-4,5-dinitroanthracene-9,10-dione
InChIKey: GJCHQJDEYFYWER-UHFFFAOYSA-N
SMILES: O=C1C2=C(C(C3=C(C=CC(O)=C13)[N+]([O-])=O)=O)C([N+]([O-])=O)=CC=C2O
Biological Activity: 1,8-Dihydroxy-4,5-dinitroanthraquinone (ARDP0006; DHDNE) is a potent inhibitor of serine proteinase NS2B/3, the dengue viral protein. 1,8-Dihydroxy-4,5-dinitroanthraquinone has intermolecular proteinase activity and viral inhibition ability with IC50s of 432 μM and 4.2 μM, respectively. Meanwhile 1,8-Dihydroxy-4,5-dinitroanthraquinone inhibits NS2B/3 cleavage in BHK-21 cells at a dose ranging from 4.2 μM to 432 μM[1].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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1,8-Dihydroxy-4,5-dinitroanthraquinone | 98.03% | 1,8-Dihydroxy-4,5-dinitroanthraquinone (ARDP0006; DHDNE) is a potent inhibitor of serine proteinase NS2B/3, the dengue viral protein. 1,8-Dihydroxy-4,5-dinitroanthraquinone has intermolecular proteinase activity and viral inhibition ability with IC50s of 432 μM and 4.2 μM, respectively. Meanwhile 1,8-Dihydroxy-4,5-dinitroanthraquinone inhibits NS2B/3 cleavage in BHK-21 cells at a dose ranging from 4.2 μM to 432 μM. | ||||||||||||||||||||
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