2. Anti-infection
  3. Virus Protease
  4. 2-Hydroxy-4-methylbenzenesulphonic acid ammonium

2-Hydroxy-4-methylbenzenesulphonic acid ammonium 

Cat. No.: HY-136574 Purity: 99.81%
COA Handling Instructions

2-Hydroxy-4-methylbenzenesulphonic acid ammonium is an impurity of Policresulen. Policresulen is a potent NS2B/NS3 protease inhibitor with an IC50 of 0.48 μg/mL. Policresulen effectively inhibits the replication of DENV2 virus in BHK-21 cells with an IC50 of 4.99 μg/mL. Policresulen acted as a competitive inhibitor of the protease, and slightly affected the protease stability.

For research use only. We do not sell to patients.

2-Hydroxy-4-methylbenzenesulphonic acid ammonium Chemical Structure

2-Hydroxy-4-methylbenzenesulphonic acid ammonium Chemical Structure

CAS No. : 79093-71-3

Size Price Stock Quantity
10 mg USD 50 In-stock
Estimated Time of Arrival: December 31
25 mg USD 100 In-stock
Estimated Time of Arrival: December 31
50 mg USD 160 In-stock
Estimated Time of Arrival: December 31
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Based on 1 publication(s) in Google Scholar

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Description

2-Hydroxy-4-methylbenzenesulphonic acid ammonium is an impurity of Policresulen. Policresulen is a potent NS2B/NS3 protease inhibitor with an IC50 of 0.48 μg/mL. Policresulen effectively inhibits the replication of DENV2 virus in BHK-21 cells with an IC50 of 4.99 μg/mL. Policresulen acted as a competitive inhibitor of the protease, and slightly affected the protease stability[1].

Molecular Weight

205.23

Appearance

Solid

Formula

C7H11NO4S
CAS No.
SMILES

O=S(C1=CC=C(C)C=C1O)(O)=O.N
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Solvent & Solubility
In Vitro: 

DMSO : 125 mg/mL (609.07 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 4.8726 mL 24.3629 mL 48.7258 mL
5 mM 0.9745 mL 4.8726 mL 9.7452 mL
10 mM 0.4873 mL 2.4363 mL 4.8726 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.08 mg/mL (10.13 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.08 mg/mL (10.13 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.08 mg/mL (10.13 mM); Clear solution

*All of the co-solvents are available by MCE.
Purity & Documentation

Purity: 99.81%

COA (256 KB) HNMR (245 KB) LCMS (258 KB)

Handling Instructions (2659 KB)
References
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

Keywords:

2-Hydroxy-4-methylbenzenesulphonic acid79093-71-3Virus ProteaseInhibitorinhibitorinhibit

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2-Hydroxy-4-methylbenzenesulphonic acid ammonium
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