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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
14 Results for "
Benzylguanine
" in MedChemExpress (MCE) Product Catalog:
Products (14)
14 Results for "Benzylguanine" in MCE Product Catalog:
3
3 Cited Publications
Cat. No.: HY-W002585
CAS No.: 19916-73-5
Research Areas:
Cardiovascular Disease Neurological Disease Inflammation/Immunology Cancer
O6-Benzylguanine is an orally active, blood-brain barrier-penetrant inhibitor of O 6-methylguanine-DNA methyltransferase (MGMT/AGT). O6-Benzylguanine modulates p53 and its downstream p21 and cyclins to induce cell cycle arrest and apoptosis, and on the other hand activates mTORC1/MAPK and other signaling pathways to induce cellular senescence by inhibiting intracellular MGMT. O6-Benzylguanine is used in research related to various tumors, cellular senescence, and vascular smooth muscle dysfunction .
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Alkyne-SNAP (compound 3) is an Alkyne-conjugated benzylguanine. The benzylguanine moiety reacts with the SNAP-tag, allowing irreversible and covalent labeling of SNAP fusion proteins with an additional alkyne functionality for further click chemistry conjugation .
Cat. No.: HY-151646
Purity: 99.59%
Synonyms: Alkyne-PEG5-BG
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Alkyne-PEG5-SNAP is a click chemistry reagent containing an alkyne group. Alkyne-PEG5-SNAP can alkyne conjugated benzylguanine (BG), the BG moiety reacts specifically and rapidly with SNAP-tag, a polypeptide protein tag, allowing irreversible and covalent labeling of SNAP fusion proteins with an additional alkyne functionality suitable for further conjugation . Alkyne-PEG5-SNAP is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
Cat. No.: HY-P3983
CAS No.: 123380-68-7
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Cat. No.: HY-W002585R
CAS No.: 19916-73-5
O6-Benzylguanine Standard is the analytical standard of O6-Benzylguanine (HY-W002585). This product is intended for research and analytical applications. O6-Benzylguanine is an orally active, blood-brain barrier-penetrant inhibitor of O 6-methylguanine-DNA methyltransferase (MGMT/AGT). O6-Benzylguanine modulates p53 and its downstream p21 and cyclins to induce cell cycle arrest and apoptosis, and on the other hand activates mTORC1/MAPK and other signaling pathways to induce cellular senescence by inhibiting intracellular MGMT. O6-Benzylguanine is used in research related to various tumors, cellular senescence, and vascular smooth muscle dysfunction .
Cat. No.: HY-D2994
CAS No.: 2434651-49-5
Synonyms: SNAP-MaP555
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SPY555-BG (SNAP-MaP555) is a cell-permeable fluorescent dye for SNAP-tag labeling of HIV-1 Gag, which enables visualization of HIV-1 intercellular transmission via SNAPf. SPY555-BG relies on irreversible covalent binding to the active-site cysteine of the SNAPf tag fused to HIV-1 Gag .
Cat. No.: HY-D2929
CAS No.: 2461569-42-4
Synonyms: SNAP-JF585
Cat. No.: HY-W002585A
CAS No.: 100994-97-6
Research Areas:
Cardiovascular Disease Neurological Disease Inflammation/Immunology Cancer
O6-Benzylguanine sodium is an orally active, blood-brain barrier-penetrant inhibitor of O 6-methylguanine-DNA methyltransferase (MGMT/AGT). O6-Benzylguanine sodium modulates p53 and its downstream p21 and cyclins to induce cell cycle arrest and apoptosis, and on the other hand activates mTORC1/MAPK and other signaling pathways to induce cellular senescence by inhibiting intracellular MGMT. O6-Benzylguanine sodium is used in research related to various tumors, cellular senescence, and vascular smooth muscle dysfunction .
Cat. No.: HY-D3603
CAS No.: 928817-42-9
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Benzylguanine-CY5 is a quenched fluorescent dye conjugate based on benzylguanine (BG). Benzylguanine-CY5 possesses the activity of specifically covalently labeling SNAP-tag fusion proteins. Benzylguanine-CY5 exhibits intramolecular fluorescence quenching in the unbound state; upon binding to SNAP-tag, the quenching guanine moiety is cleaved, and its fluorescence intensity increases. Benzylguanine-CY5 can be used for background-free specific fluorescent labeling and imaging studies of SNAP-tag fusion proteins in living cells .
Cat. No.: HY-N15896
CAS No.: 2389168-47-0
Cat. No.: HY-N15911
CAS No.: 2315262-37-2
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Cat. No.: HY-D2925
Synonyms: dTCO-SNAP
Cat. No.: HY-D2932
CAS No.: 1041172-60-4
Synonyms: SNAP-Maleimide
Cat. No.: HY-D2957
CAS No.: 3074567-08-8
Synonyms: NorBG; SNAP-Nor
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
