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Results for "

Bisphosphonate

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Apoptosis (30) Autophagy (8) Bacterial (10) Biochemical Assay Reagents (2) CXCR (1) Drug Derivative (1) Environmental Pollutants (1) Farnesyl Transferase (5) Fluorescent Dye (2) Interleukin Related (3) Isotope-Labeled Compounds (9) NF-κB (3) Parasite (6) Phosphatase (1) Phospholipase (1) Proton Pump (4) RANKL/RANK (6) Ras (1) Reference Standards (10) Survivin (1) Toll-like Receptor (TLR) (6) Wnt (6) β-catenin (6)
By Research Areas:	Cancer (43) Endocrinology (1) Infection (10) Inflammation/Immunology (14) Metabolic Disease (33) Neurological Disease (2)

By Targets:

Apoptosis (30)

Autophagy (8)

Bacterial (10)

Biochemical Assay Reagents (2)

CXCR (1)

Drug Derivative (1)

Environmental Pollutants (1)

Farnesyl Transferase (5)

Fluorescent Dye (2)

Interleukin Related (3)

Isotope-Labeled Compounds (9)

NF-κB (3)

Parasite (6)

Phosphatase (1)

Phospholipase (1)

Proton Pump (4)

RANKL/RANK (6)

Ras (1)

Reference Standards (10)

Survivin (1)

Toll-like Receptor (TLR) (6)

Wnt (6)

β-catenin (6)

By Research Areas:

Cancer (43)

Endocrinology (1)

Infection (10)

Inflammation/Immunology (14)

Metabolic Disease (33)

Neurological Disease (2)

Inhibitors & Agonists

Fluorescent Dyes

Peptides

Isotope-Labeled Compounds

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-13777

Zoledronic Acid Maximum Cited Publications 24 Publications Verification Zoledronate; CGP 42446; CGP42446A; ZOL 446	Apoptosis Autophagy Bacterial	Metabolic Disease Cancer
Zoledronic Acid (Zoledronate) is a third-generation bisphosphonate (BP), with potent anti-resorptive activity. Zoledronic Acid inhibits the differentiation and apoptosis of osteoclasts. Zoledronic Acid also has anti-cancer effects .

HY-B0631

Alendronic acid 5+ Cited Publications	NF-κB Interleukin Related	Metabolic Disease
Alendronate acid is an orally active bisphosphonate which binds to bone surfaces and inhibits bone resorption by osteoclasts. Alendronate acid induces skeletal alterations in the chicken embryonic development model. Alendronate acid can be used for osteoporosis research .

HY-108309

Medronic acid 1 Publications Verification Methylenediphosphonic acid	Biochemical Assay Reagents	Others
Medronic acid (Methylenediphosphonic acid) is a methylene-substituted bisphosphonate. Medronic acid has an affinity for the surface of hydroxyapatite crystals in the bone matrix and adheres to them. Medronic acid can be used in complex with radioisotopes in bone imaging. Due to its strong metal chelating ability, medronic acid is also used as a water treatment chemical. In addition, medronic acid is used as a solvent additive to improve peak shape and signal of metal-sensitive metabolites in LC/MS analysis .

HY-13777A

Zoledronic acid monohydrate Maximum Cited Publications 24 Publications Verification Zoledronate monohydrate; CGP 42446 monohydrate; CGP42446A monohydrate; ZOL 446 monohydrate	Apoptosis Autophagy Bacterial	Metabolic Disease Cancer
Zoledronic acid monohydrate (Zoledronate monohydrate) is a third-generation bisphosphonate (BP), with potent anti-resorptive activity. Zoledronic acid monohydrate inhibits the differentiation and apoptosis of osteoclasts. Zoledronic acid monohydrate also has anti-cancer effects .

HY-108685

Alendronate sodium 5+ Cited Publications Alendronic acid monosodium salt	NF-κB Interleukin Related	Metabolic Disease
Alendronate sodium is an orally active bisphosphonate which binds to bone surfaces and inhibits bone resorption by osteoclasts. Alendronate sodium induces skeletal alterations in the chicken embryonic development model. Alendronate sodium can be used for osteoporosis research .

HY-B0302

Etidronic acid 1 Publications Verification Etidronate; HEDPA; HEDP	Environmental Pollutants Apoptosis	Metabolic Disease Cancer
Etidronic acid (Etidronate) is an orally and intravenously active bisphosphonate. Etidronic acid inhibits resorption of bone, reduces arterial calcification and can be used for osteoporosis research. Etidronic acid has anticancer activity. Etidronic acid is a chelating agent and can be used to remove heavy metal in water .

HY-B0657A

Clodronic acid disodium salt 4 Publications Verification Clodronate disodium salt	Apoptosis	Metabolic Disease Cancer
Clodronic acid (Clodronate) disodium salt is an orally active bisphosphonate. Clodronic acid disodium salt inhibits osteoclast-mediated bone resorption. Clodronic acid disodium salt reduces skeletal event risk in malignant bone disease, impairs malignant osteolysis, blocks bone matrix growth-factor release, induces apoptosis in osteoclasts and macrophages. Clodronic acid disodium salt is effective in the maintenance or improvement of bone mineral density. Clodronic acid disodium salt can be used for the research of multiple myeloma and postmenopausal osteoporosis .

HY-B0302A

Etidronic acid disodium 1 Publications Verification Etidronate disodium; HEDPA disodium; HEDP disodium	Apoptosis	Metabolic Disease Cancer
Etidronic acid (Etidronate) disodium is an orally and intravenously active bisphosphonate. Etidronic acid disodium inhibits resorption of bone, reduces arterial calcification and can be used for osteoporosis research. Etidronic acid disodium has anticancer activity. Etidronic acid disodium is a chelating agent and can be used to remove heavy metal in water .

HY-B0148

Risedronic acid 2 Publications Verification Risedronate	Parasite Apoptosis	Infection Metabolic Disease Cancer
Risedronic acid (Risedronate) is a bisphosphonate and potent antiresorptive agent. Risedronic acid induces Apoptosis. Risedronic acid inhibits the transfer of farnesyl pyrophosphate groups to parasite proteins. Risedronic acid inhibits osteoclast-mediated bone resorption and alters bone metabolism. Risedronic acid inhibits blood-stage Plasmodium falciparum (IC₅₀ of 20.3 μM) .

HY-150168

TH-Z145	Bacterial	Infection
TH-Z145, a lipophilic bisphosphonate, is a FPPS inhibitor (IC₅₀: 210 nM) .

HY-107794

Clodronate disodium tetrahydrate 4 Publications Verification Disodium clodronate tetrahydrate	Apoptosis	Neurological Disease Inflammation/Immunology Cancer
Clodronate disodium tetrahydrate (Disodium clodronate tetrahydrate) is first-generation bisphosphonate, with anti-osteoporotic, anti-inflammatory and analgesic effects. Clodronate disodium tetrahydrate is a selective, potent, reversible and Cl ^- competitive vesicular nucleotide transporter (VNUT) inhibitor, with an IC₅₀ of 15.6 nM. Clodronate disodium tetrahydrate inhibits vesicular ATP release from neurons and reduces chronic neuropathic and inflammatory pain .

HY-A0213A

Tiludronate disodium 1 Publications Verification Tiludronic acid disodium	Proton Pump	Inflammation/Immunology
Tiludronate (Tiludronic Acid) disodium, an orally active bisphosphonate, can act an osteoregulator. Tiludronate is used for the research of the metabolic bone disorders. Tiludronate is a potent inhibitor of the osteoclast vacuolar H(+)-ATPase. Antiresorptive and anti-inflammatory properties .

HY-16011

NE 10790 2 Publications Verification 3-PEHPC	Farnesyl Transferase	Others
NE 10790, a poor farnesyl pyrophosphate synthase inhibitor, is a phosphonocarboxylate analogue of the potent bisphosphonate risedronate and is a weak antiresorptive agent.

HY-B0119

Risedronic acid sodium 2 Publications Verification Risedronate sodium	Parasite Apoptosis	Infection Metabolic Disease Cancer
Risedronic acid (Risedronate) sodium, a bisphosphonate, is a potent anti-resorption agent that inhibits osteoclast-mediated bone resorption and changes the bone metabolism. Risedronic acid sodium suppresses osteoblast differentiation and induced caspase- and isoprenoid depletion-dependent apoptosis. Risedronic acid sodium inhibits blood stages of Plasmodium falciparum (IC₅₀ of 20.3 μM). Risedronic acid sodium inhibits the transfer of the farnesyl pyrophosphate group to parasite proteins .

HY-B0012

Pamidronic acid 1 Publications Verification	RANKL/RANK Toll-like Receptor (TLR) Wnt β-catenin	Metabolic Disease Inflammation/Immunology Cancer
Pamidronic acid, the second-generation nitrogen-containing bisphosphonate, is an inhibitor of bone loss. Pamidronic acid significantly inhibits subchondral bone loss in early osteoarthritis by upregulating the expression of OPG in cartilage and subchondral bone, and inhibiting the expression of RANKL and MMP-9 in both tissues, as well as TLR-4 in cartilage, thereby alleviating cartilage degeneration. Additionally, Pamidronic acid can inhibit the signaling of Wnt and β-catenin, and is applicable for research on osteoporosis and osteosarcoma .

HY-U00145

Digeranyl bisphosphonate 3 Publications Verification DGBP	Ras	Inflammation/Immunology
Digeranyl bisphosphonate (DGBP) is a potent geranylgeranylpyrophosphate (GGPP) synthase inhibitor, which inhibits geranylgeranylation of Rac1.

HY-48917

C10 Bisphosphonate	Phospholipase Apoptosis	Inflammation/Immunology
C10 Bisphosphonate is an acid sphingomyelinase (aSMase) inhibitor with an IC₅₀ of 0.02 μM in rats. C10 Bisphosphonate inhibits Dexamethasone (HY-14648)-induced cell apoptosis (apoptosis) and alleviates platelet-activating factor (PAF)-induced pulmonary edema. C10 Bisphosphonate can be used for the research of pulmonary edema .

HY-B0012A

Pamidronate disodium 1 Publications Verification CGP 23339A	RANKL/RANK Toll-like Receptor (TLR) Wnt β-catenin	Metabolic Disease Inflammation/Immunology Cancer
Pamidronate disodium (CGP 23339A), the second-generation nitrogen-containing bisphosphonate, is an inhibitor of bone loss. Pamidronate disodium significantly inhibits subchondral bone loss in early osteoarthritis by upregulating the expression of osteoprotegerin in cartilage and subchondral bone, and inhibiting the expression of RANKL and MMP-9 in both tissues, as well as TLR-4 in cartilage, thereby alleviating cartilage degeneration. Additionally, Pamidronate disodium can inhibit the signaling of Wnt and β-catenin, and is applicable for research on osteoporosis and osteosarcoma .

HY-B0730

Pamidronate disodium pentahydrate 1 Publications Verification	RANKL/RANK Toll-like Receptor (TLR) Wnt β-catenin	Metabolic Disease Inflammation/Immunology Cancer
Pamidronate disodium pentahydrate, the second-generation nitrogen-containing bisphosphonate, is an inhibitor of bone loss. Pamidronate disodium pentahydrate significantly inhibits subchondral bone loss in early osteoarthritis by upregulating the expression of osteoprotegerin in cartilage and subchondral bone, and inhibiting the expression of RANKL and MMP-9 in both tissues, as well as TLR-4 in cartilage, thereby alleviating cartilage degeneration. Additionally, Pamidronate disodium pentahydrate can inhibit the signaling of Wnt and β-catenin, and is applicable for research on osteoporosis and osteosarcoma .

HY-B0657

Clodronic acid 4 Publications Verification Clodronate	Apoptosis	Metabolic Disease Cancer
Clodronic acid (Clodronate) is an orally active bisphosphonate. Clodronic acid inhibits osteoclast-mediated bone resorption. Clodronic acid reduces skeletal event risk in malignant bone disease, impairs malignant osteolysis, blocks bone matrix growth-factor release, induces apoptosis in osteoclasts and macrophages. Clodronic acid is effective in the maintenance or improvement of bone mineral density. Clodronic acid can be used for the research of multiple myeloma and postmenopausal osteoporosis .

HY-150167

TH-Z93	Bacterial	Infection
TH-Z93, a lipophilic bisphosphonate, is a FPPS inhibitor (IC₅₀: 90 nM) .

HY-113752

MMV019313	Parasite	Infection
MMV019313 is a potent, non-bisphosphonate inhibitor of farnesyl/geranylgeranyl diphosphate synthase (FPPS/GGPPS) with an IC₅₀ of 0.82 µM. MMV019313 has activity against P. falciparum (Parasite) .

HY-107093

MBC-11	Apoptosis	Cancer
MBC-11 is a first-in-class conjugate of the bone-targeting bisphosphonate etidronate covalently linked to the antimetabolite cytarabine (araC). MBC-11 has the potential for tumor-induced bone disease (TIBD) research .

HY-108309R

Medronic acid (Standard) Methylenediphosphonic acid (Standard)	Biochemical Assay Reagents Reference Standards	Others
Medronic acid (Standard) is the analytical standard of Medronic acid. This product is intended for research and analytical applications. Medronic acid (Methylenediphosphonic acid) is a methylene-substituted bisphosphonate. Medronic acid has affinity for and adheres to the surface of hydroxyapatite crystals in the bone matrix. Medronic acid can be used in bone imaging, while being complexed with radioisotopes. Due to its strong metal-chelating ability, Medronic acid can also be used as a water treatment chemical .

HY-B2097

Incadronate disodium YM 175; Bisphonal	Farnesyl Transferase	Metabolic Disease
Incadronate disodium (YM 175) is a bisphosphonate with strong inhibitory activity on bone resorption. Incadronate disodium indirectly stimulates renal 25-hydroxyvitamin D-1-hydroxylase by increasing circulating parathyroid hormone. Incadronate disodium, a cholesterol-lowering agent, is a potent inhibitor of rat liver microsomal squalene synthase (K_i=57 nM). Incadronate disodium inhibits sterol biosynthesis in mouse macrophage J774 cells (IC₅₀=64 μM). Incadronate disodium has the potential for malignant tumors research .

HY-A0213

Tiludronate Tiludronic acid	Proton Pump	Inflammation/Immunology
Tiludronate (Tiludronic Acid), an orally active bisphosphonate, can act an osteoregulator. Tiludronate is used for the research of the metabolic bone disorders. Tiludronate is a potent inhibitor of the osteoclast vacuolar H(+)-ATPase. Antiresorptive and anti-inflammatory properties .

HY-B0515A

Ibandronic acid	Others	Cancer
Ibandronic acid is a highly effective nitrogen-containing bisphosphonate that can be used for osteoporosis.

HY-D2133

Cy5-ALN Alendronate-Cy5	Fluorescent Dye	Others
Cy5-ALN (Alendronate-Cy5) is a fluorescently labeled bisphosphonate probe .

HY-118224

BPH-715	Parasite	Infection
BPH-715 is a bisphosphonate, inhibits Plasmodium liver-stage growth, with an IC₅₀ of 10 μM for Plasmodium exoerythrocytic forms in HepG2 cells .

HY-B0631S

Alendronic acid-d6	Isotope-Labeled Compounds	Cancer
Alendronic acid-d₆ is the deuterium labeled Alendronic acid. Alendronic acid, a bisphosphonate, is a farnesyl diphosphate synthase (FDPS) inhibitor. Alendronic acid inhibits osteoclast-mediated bone resorption. Alendronic acid shows efficacy in postmenopausal osteoporosis, malignant hypercalcemia and Paget’s disease .

HY-B0148R

Risedronic acid (Standard) Risedronate (Standard)	Parasite Reference Standards Apoptosis	Infection Metabolic Disease Cancer
Risedronic acid (Standard) (Risedronate (Standard)) is the analytical standard of Risedronic acid (HY-B0148). This product is intended for research and analytical applications. Risedronic acid (Risedronate) is a bisphosphonate and potent antiresorptive agent. Risedronic acid induces Apoptosis. Risedronic acid inhibits the transfer of farnesyl pyrophosphate groups to parasite proteins. Risedronic acid inhibits osteoclast-mediated bone resorption and alters bone metabolism. Risedronic acid inhibits blood-stage Plasmodium falciparum (IC₅₀ of 20.3 μM).

HY-B0148S

Risedronic acid-d4 Risedronate-d₄	Isotope-Labeled Compounds Parasite Apoptosis	Infection Metabolic Disease Cancer
Risedronic acid-d₄ (Risedronate-d₄) is the deuterium labeled Risedronic acid (HY-B0148). Risedronic acid (Risedronate) is a bisphosphonate and potent antiresorptive agent. Risedronic acid induces Apoptosis. Risedronic acid inhibits the transfer of farnesyl pyrophosphate groups to parasite proteins. Risedronic acid inhibits osteoclast-mediated bone resorption and alters bone metabolism. Risedronic acid inhibits blood-stage Plasmodium falciparum (IC₅₀ of 20.3 μM) .

HY-13777B

Zoledronic acid disodium tetrahydrate Zoledronate disodium tetrahydrate; CGP 42446 disodium tetrahydrate; CGP42446A disodium tetrahydrate; ZOL 446 disodium tetrahydrate	Apoptosis Autophagy Bacterial	Metabolic Disease Cancer
Zoledronic Acid (Zoledronate) disodium tetrahydrate is a third-generation bisphosphonate (BP), with potent anti-resorptive activity. Zoledronic Acid disodium tetrahydrate inhibits the differentiation and apoptosis of osteoclasts. Zoledronic Acid disodium tetrahydrate also has anti-cancer effects .

HY-19295

TRK-530 sodium	CXCR	Inflammation/Immunology Endocrinology
TRK-530 sodium is an orally active bisphosphonate. TRK-530 sodium inhibits CINC-1. TRK-530 sodium inhibits dental calculus formation. TRK-530 sodium also inhibits paw edema, joint destruction and osteomyelitis .

HY-13777S1

Zoledronic acid-d3 Zoledronate-d₃; CGP 42446-d₃; CGP42446A-d₃; ZOL 446-d₃	Isotope-Labeled Compounds Apoptosis Bacterial Autophagy	Metabolic Disease Cancer
Zoledronic acid-d₃ (Zoledronate-d₃) is the deuterium labeled Zoledronic acid (HY-13777). Zoledronic Acid (Zoledronate) is a third-generation bisphosphonate (BP), with potent anti-resorptive activity. Zoledronic Acid inhibits the differentiation and apoptosis of osteoclasts. Zoledronic Acid also has anti-cancer effects .

HY-A0213AS

Tiludronate-d5 sodium Tiludronic acid-d5 sodium	Isotope-Labeled Compounds Proton Pump	Inflammation/Immunology
Tiludronate-d₅ (sodium)mis the deuterium labeled Tiludronate disodium. Tiludronate (Tiludronic Acid) disodium, an orally active bisphosphonate, can act an osteoregulator. Tiludronate is used for the research of the metabolic bone disorders. Tiludronate is a potent inhibitor of the osteoclast vacuolar H(+)-ATPase. Antiresorptive and anti-inflammatory properties .

HY-144128

hGGPPS-IN-1	Apoptosis	Cancer
hGGPPS-IN-1 (Compound 18b) is a potent inhibitor of the human geranylgeranyl pyrophosphate synthase (hGGPPS). hGGPPS-IN-1 is an analogue of C-2-substituted thienopyrimidine-based bisphosphonates (C2-ThP-BPs). hGGPPS-IN-1 induces target-selective apoptosis of multiple myeloma (MM) cells and exhibits antimyeloma activity in vivo .

HY-136829

BPH-675	Apoptosis	Others
BPH-675 is a large bisphosphonate inhibitor with long hydrophobic side chains and a potent and selective geranylgeranyl diphosphate synthase (GGPPS) inhibitor with an IC₅₀ of 0.71 μM. GGPPS inhibitor promotes HUVEC apoptosis .

HY-A0213B

Tiludronate disodium hemihydrate Tiludronic acid disodium hemihydrate	Proton Pump	Metabolic Disease
Tiludronate (Tiludronic Acid) disodium hemihydrate, an orally active bisphosphonate, can act an osteoregulator. Tiludronate disodium hemihydrate is used for the research of the metabolic bone disorders. Tiludronate disodium hemihydrate is a potent inhibitor of the osteoclast vacuolar H ⁺-ATPase. Antiresorptive and anti-inflammatory properties .

HY-13777R

Zoledronic Acid (Standard) Zoledronate (Standard); CGP 42446 (Standard); CGP42446A (Standard); ZOL 446 (Standard)	Reference Standards Apoptosis Autophagy Bacterial	Metabolic Disease Cancer
Zoledronic Acid (Standard) is the analytical standard of Zoledronic Acid. This product is intended for research and analytical applications. Zoledronic Acid (Zoledronate) is a third-generation bisphosphonate (BP), with potent anti-resorptive activity. Zoledronic Acid inhibits the differentiation and apoptosis of osteoclasts. Zoledronic Acid also has anti-cancer effects .

HY-13777AR

Zoledronic acid monohydrate (Standard) Zoledronate monohydrate (Standard); CGP 42446 monohydrate (Standard); CGP42446A monohydrate (Standard); ZOL 446 monohydrate (Standard)	Reference Standards Apoptosis Autophagy Bacterial	Metabolic Disease Cancer
Zoledronic acid (monohydrate) (Standard) is the analytical standard of Zoledronic acid (monohydrate). This product is intended for research and analytical applications. Zoledronic acid monohydrate (Zoledronate monohydrate) is a third-generation bisphosphonate (BP), with potent anti-resorptive activity. Zoledronic acid monohydrate inhibits the differentiation and apoptosis of osteoclasts. Zoledronic acid monohydrate also has anti-cancer effects .

HY-13777S

Zoledronic acid-d5 Zoledronate-d₅; CGP 42446-d₅; CGP42446A-d₅; ZOL 446-d₅	Bacterial Apoptosis Autophagy Isotope-Labeled Compounds	Metabolic Disease Cancer
Zoledronic acid-d₅ is deuterated labeled Zoledronic Acid (HY-13777). Zoledronic Acid (Zoledronate) is a third-generation bisphosphonate (BP), with potent anti-resorptive activity. Zoledronic Acid inhibits the differentiation and apoptosis of osteoclasts. Zoledronic Acid also has anti-cancer effects .

HY-119001

BKM1644	Survivin	Cancer
BKM1644, an acyl-tyrosine bisphosphonate amide derivative, exhibits potent anti-cancer activity. BKM1644 effectively inhibits the proliferation of metastatic, castration-resistant prostate cance (mCRPC) cells. BKM1644 sensitizes mCRPC cells to Docetaxel (HY-B0011) and retards the bone metastatic growth of prostate cance .

HY-B0515AS1

Ibandronic acid-d3	Apoptosis Isotope-Labeled Compounds	Cancer
Ibandronic acid-d₃ is the deuterium labeled Ibandronic acid. Ibandronic acid is a highly potent nitrogen-containing bisphosphonate used for the treatment of osteoporosis.

HY-B0515AS

Ibandronic Acid-d3 sodium salt	Apoptosis Isotope-Labeled Compounds	Cancer
Ibandronic Acid-d₃ (sodium) is the deuterium labeled Ibandronic acid. Ibandronic acid is a highly potent nitrogen-containing bisphosphonate used for the treatment of osteoporosis[1][2].

HY-107093B

MBC-11 triethylamine	Apoptosis	Cancer
MBC-11 triethylamine is a first-in-class conjugate of the bone-targeting bisphosphonate etidronate covalently linked to the antimetabolite cytarabine (araC). MBC-11 triethylamine has the potential for tumor-induced bone disease (TIBD) research .

HY-107093A

MBC-11 trisodium	Apoptosis	Cancer
MBC-11 trisodium is a first-in-class conjugate of the bone-targeting bisphosphonate HEDP covalently linked to the antimetabolite Ara-C. MBC-11 trisodium has the potential for tumor-induced bone disease (TIBD) research .

HY-108685S

Alendronate-d4 sodium Alendronic acid-d4 monosodium salt	Isotope-Labeled Compounds	Metabolic Disease Cancer
Alendronate-d₄ (sodium) (Alendronic acid-d₄ (monosodium salt)) is deuterium labeled Alendronate sodium. Alendronate sodium is an orally active nitrogen-containing bisphosphonate. Alendronate sodium potently inhibits bone resorption. Alendronate sodium is used for the research of postmenopausal osteoporosis .

HY-106431

Olpadronic acid Olpadronate; OLP	Farnesyl Transferase	Metabolic Disease Cancer
Olpadronic acid (Olpadronate) is an orally active amino-bisphosphonate and inhibits bone resorption. Olpadronic acid also prevents bone destruction and tumor growth in the skeletal prostate cancer mouse model. Olpadronic acid can be used for research of osteoporosis, malignancies and rheumatoid arthritis .

HY-106431R

Olpadronic acid (Standard) Olpadronate (Standard); OLP (Standard)	Reference Standards Others	Metabolic Disease Cancer
Olpadronic acid (Standard) is the analytical standard of Olpadronic acid. This product is intended for research and analytical applications. Olpadronic acid (Olpadronate) is an orally active amino-bisphosphonate and inhibits bone resorption. Olpadronic acid also prevents bone destruction and tumor growth in the skeletal prostate cancer mouse model. Olpadronic acid can be used for research of osteoporosis, malignancies and rheumatoid arthritis .

Cat. No.	Product Name	Target	Research Area

HY-P5284

RALA peptide	Peptides	Others
RALA peptide is a cationic amphiphilic delivery agent targeting cell membranes, which forms nanoparticles through electrostatic interactions with anionic drugs. RALA peptide has pH-responsive binding properties, which can enhance the α-helical conformation in an acidic environment and destroy the endosomal membrane, promote the release of drugs into the cytoplasm, and exert efficient intracellular delivery activity. RALA peptide can be used in cancer research (enhancing the activity of bisphosphonates against prostate cancer and breast cancer cells) and bone tissue engineering (promoting osteoblast collagen deposition and extracellular matrix mineralization) .

Cat. No.	Product Name	Chemical Structure

HY-B0631S

Alendronic acid-d6
Alendronic acid-d₆ is the deuterium labeled Alendronic acid. Alendronic acid, a bisphosphonate, is a farnesyl diphosphate synthase (FDPS) inhibitor. Alendronic acid inhibits osteoclast-mediated bone resorption. Alendronic acid shows efficacy in postmenopausal osteoporosis, malignant hypercalcemia and Paget’s disease .

HY-B0148S

Risedronic acid-d4

Risedronic acid-d₄ (Risedronate-d₄) is the deuterium labeled Risedronic acid (HY-B0148). Risedronic acid (Risedronate) is a bisphosphonate and potent antiresorptive agent. Risedronic acid induces Apoptosis. Risedronic acid inhibits the transfer of farnesyl pyrophosphate groups to parasite proteins. Risedronic acid inhibits osteoclast-mediated bone resorption and alters bone metabolism. Risedronic acid inhibits blood-stage Plasmodium falciparum (IC₅₀ of 20.3 μM) .

HY-13777S1

Zoledronic acid-d3
Zoledronic acid-d₃ (Zoledronate-d₃) is the deuterium labeled Zoledronic acid (HY-13777). Zoledronic Acid (Zoledronate) is a third-generation bisphosphonate (BP), with potent anti-resorptive activity. Zoledronic Acid inhibits the differentiation and apoptosis of osteoclasts. Zoledronic Acid also has anti-cancer effects .

HY-A0213AS

Tiludronate-d5 sodium
Tiludronate-d₅ (sodium)mis the deuterium labeled Tiludronate disodium. Tiludronate (Tiludronic Acid) disodium, an orally active bisphosphonate, can act an osteoregulator. Tiludronate is used for the research of the metabolic bone disorders. Tiludronate is a potent inhibitor of the osteoclast vacuolar H(+)-ATPase. Antiresorptive and anti-inflammatory properties .

HY-13777S

Zoledronic acid-d5
Zoledronic acid-d₅ is deuterated labeled Zoledronic Acid (HY-13777). Zoledronic Acid (Zoledronate) is a third-generation bisphosphonate (BP), with potent anti-resorptive activity. Zoledronic Acid inhibits the differentiation and apoptosis of osteoclasts. Zoledronic Acid also has anti-cancer effects .

HY-B0515AS1

Ibandronic acid-d3
Ibandronic acid-d₃ is the deuterium labeled Ibandronic acid. Ibandronic acid is a highly potent nitrogen-containing bisphosphonate used for the treatment of osteoporosis.

HY-B0515AS

Ibandronic Acid-d3 sodium salt
Ibandronic Acid-d₃ (sodium) is the deuterium labeled Ibandronic acid. Ibandronic acid is a highly potent nitrogen-containing bisphosphonate used for the treatment of osteoporosis[1][2].

HY-108685S

Alendronate-d4 sodium
Alendronate-d₄ (sodium) (Alendronic acid-d₄ (monosodium salt)) is deuterium labeled Alendronate sodium. Alendronate sodium is an orally active nitrogen-containing bisphosphonate. Alendronate sodium potently inhibits bone resorption. Alendronate sodium is used for the research of postmenopausal osteoporosis .

HY-W777154

Zoledronic acid-15N2,13C2
Zoledronic acid- ¹⁵N₂, ¹³C₂ (CGP 42446- ¹⁵N₂, ¹³C₂) is the ¹³C- and ¹⁵N-labeled Zoledronic Acid (HY-13777). Zoledronic Acid (Zoledronate) is a third-generation bisphosphonate (BP), with potent anti-resorptive activity. Zoledronic Acid inhibits the differentiation and apoptosis of osteoclasts. Zoledronic Acid also has anti-cancer effects .

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