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C. albicans strains

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Cytochrome P450 (1) Fungal (6)
By Research Areas:	Infection (6)

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Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-169165

14α-Demethylase-IN-1	Fungal	Infection
14α-Demethylase-IN-1 (compound 2e) is a 14α-demethylase inhibitor and can be used as an antifungal agent. 14α-Demethylase-IN-1 (48 h) exhibits MIC50 values of 2.47 μM, 1.23 μM, 19.70 μM, and 19.70 μM for C. albicans, C. parapsilosis, C. krusei, and C. glabrata, respectively .

HY-146024

Antifungal agent 28	Fungal	Infection
Antifungal agent 28 (compound 18) is a potent and selective antifungal agent. Antifungal agent 28 inhibits pathogenic strains of C. albicans and non-albicans species including fluconazole-resistant strains. Antifungal agent 28 inhibits Cryptococcus and Aspergillus strains. Antifungal agent 28 disrupts mature Candida biofilm .

HY-122134

SC-58272	Fungal	Infection
SC-58272 is a potent and selective dipeptide N-myristoyltransferase (Nmt) inhibitor with an IC₅₀ of 56 nM for C. albicans (strain B311) Nmt. SC-58272 shows 250-fold selective for the fungal enzyme compared to human enzyme .

HY-173206

Antifungal agent 128	Fungal	Infection
Antifungal agent 128 (Compound 3ja) is an antifungal agent. When used in combination with Fluconazole (HY-B0101), the MIC range against C. albicans strains is 0.5-4 μg/mL. Antifungal agent 128 can be used in the research of the anti-infection field .

HY-19377

SS-750	Fungal Cytochrome P450	Infection
SS-750 is an orally active Triazole derivative and antifungal agent. SS-750 binds to fungal cytochrome P450. SS-750 shows antifungal activities against Candida species and C. neoformans strains tested. SS750 shows MIC₉₀ values of 0.25, 1, and 2 μg/mL against Candida parapsilosis, C. krusei, and C. glabrata, respectively. SS-750 improves systemic and pulmonary candidiasis caused by C. albicans .

HY-N19506

Vincadifformine N(4)-oxide	Fungal	Infection
Vincadifformine N (4)-oxide is a monoterpenoid indole alkaloid. Vincadifformine N (4)-oxide can be isolated from Rhazya stricta. Vincadifformine N (4)-oxide shows a MIC > 50 μg/mL against tested Candida strains and exhibits no antifungal activity .

Vincadifformine N(4)-oxide	Apocynaceae Structural Classification Alkaloids Piperidine Alkaloids Plants Rhazya stricta Decne. Source Classification	Fungal
Vincadifformine N (4)-oxide is a monoterpenoid indole alkaloid. Vincadifformine N (4)-oxide can be isolated from Rhazya stricta. Vincadifformine N (4)-oxide shows a MIC > 50 μg/mL against tested Candida strains and exhibits no antifungal activity .

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BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature.

BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

MedchemExpress Validation 03

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred

MedchemExpress Validation 04

MedchemExpress Validation

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C. albicans strains

Inhibitors & Agonists

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Natural
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