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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
17 Results for "
CA IV
" in MedChemExpress (MCE) Product Catalog:
Products (17)
17 Results for "CA IV" in MCE Product Catalog:
Cat. No.: HY-W074975
CAS No.: 14949-00-9
Synonyms: 5-Amino-1,3,4-thiadiazole-2-sulfonamide
Target:
Research Areas:
CL 5343 (5-Amino-1,3,4-thiadiazole-2-sulfonamide) is a selective inhibitor of carbonic anhydrase B (HCA-B) and isoforms I, II, IV, and VII. CL 5343 has a Ki of 7.9 nM for hCA II. CL 5343 acts as a CA9 ligand to achieve targeted delivery of maytansine to the cell membrane of SKRC52 renal cancer cells. CL 5343 is useful in the development of therapeutics for diseases associated with CA overactivity, such as glaucoma, epilepsy, and cancer .
Cat. No.: HY-W424792A
CAS No.: 2967475-56-3
Target:
Research Areas:
O-Desmethyl Brinzolamide hydrochloride (compound 6a), an active metabolite of Brinzolamide, is a carbonic anhydrase (CA) inhibitor with a Kd of 0.136 nM for CA II and an IC50 of 165 nM for CA IV .
Cat. No.: HY-101136
CAS No.: 66522-52-9
Synonyms: AT-265
Target:
Research Areas:
Dealanylascamycin (AT-265) (Compound 2) is a nucleoside antibiotic. AT 265 is a carbonic anhydrase (CA) inhibitor, with Ki values of 167, 65.2, 234, and 143 nM for hCA I, hCA II, hCA IV, and hCA IX respectively. Dealanylascamycin is the active form of Ascamycin (HY-121071). Dealanylascamycin exhibits broad-spectrum antibacterial activity and is effective against pathogenic bacteria such as Xanthomonas citri (MIC = 0.4 μg/mL). Dealanylascamycin has high cytotoxicity .
Cat. No.: HY-151578
CAS No.: 2836996-95-1
Research Areas:
DPP IV/hCA II-IN-1 is a potent and selective dipeptidyl peptidase IV (DPP IV) and carbonic anhydrase (CA) inhibitor with an IC50 value of 0.049 μM for DPP IV and with Ki values of 0.0361, 0.0428, 0.0941, 0.1328, 0.2615, and 3.034 μM for CA II, CA VB, CA VA, CA IX, CA I, and CA IV, respectively .
Cat. No.: HY-RS01770
Target:
Research Areas:
CA4 Human Pre-designed siRNA Set A contains three designed siRNAs for CA4 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-178030
Research Areas:
CAXII-IN-3 is an effective carbonic anhydrase (CA XII) inhibitor with a Ki of 53 nM. CAXII-IN-3 exhibits selective inhibition against multiple human CA subtypes with Kis of 5.3 μM, 75 nM, 1.9 μM, > 10 μM against CA I, CA II, CA IV and CA IX. CAXII-IN-3 mainly inhibits CA II and XII, and reduces aqueous humor production. CAXII-IN-3 exhibits β3-AR agonistic activity, can dilate retinal blood vessels, and improve optic nerve perfusion. CAXII-IN-3 can be used in the research of ocular disorders such as glaucoma .
Cat. No.: HY-151472
CAS No.: 3031666-31-3
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hCAIX/XII-IN-6 is an orally active carbonic anhydrase (CA) inhibitor. hCAIX/XII-IN-6 inhibits human CA isoforms hCA I, II, IV, IX, and XII with Ki values of 6697 nM, 2950 nM, 4093 nM, 4.1 nM and 7.7 nM, respectively. hCAIX/XII-IN-6 can be used for the research of rheumatoid arthritis (RA) .
Cat. No.: HY-134043
CAS No.: 16289-13-7
Synonyms: Chlorthalidone EP Impurity G
Target:
Research Areas:
Chlorthalidone Impurity G (Chlorthalidone EP Impurity G) is a potential impurity found in commercial preparations of chlorthalidone with moderate antihypertensive effects. Chlorthalidone is a thiazide diuretic that inhibits the Na+/Cl- cotransporter in the distal tubule of the kidney, thereby preventing sodium and chloride reabsorption, resulting in decreased plasma volume and cardiac output. It also inhibits carbonic anhydrase (CA), including isoenzymes CAVB, VII, IX, XII, and XIII (Kis=2.8-23 nM) and to a lesser extent CAI, CAII, IV, VA, and VI (Ki=138-1,347 nM), mediating vasodilatory activity.
Cat. No.: HY-P700579
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: CAMK4; CAM Kinase IV; CAlcium/CAlmodulin Dependent Protein Kinase IV; CAMK IV; CAMK-GR; Brain CA(2+)-CAlmodulin-Dependent Protein Kinase Type IV; CAMKIV; CAM Kinase-GR; CAlcium/CAlmodulin-Dependent Protein Kinase Type IV CAtalytic Chain; CAMK-GR; Brain CA
Species:
Rat
Source:
E. coli
Cat. No.: HY-P75457
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: CAMK4; CAM Kinase IV; CAlcium/CAlmodulin Dependent Protein Kinase IV; CAMK IV; CAMK-GR; Brain CA(2+)-CAlmodulin-Dependent Protein Kinase Type IV; CAMKIV; CAM Kinase-GR; CAlcium/CAlmodulin-Dependent Protein Kinase Type IV CAtalytic Chain; CAMK-GR; Brain CA
Species:
Mouse
Source:
Sf9 insect cells
Cat. No.: HY-P702652
Purity: ≥ 80%, as determined by reducing SDS-PAGE.
Synonyms: CAMK4; CAM Kinase IV; CAlcium/CAlmodulin Dependent Protein Kinase IV; CAMK IV; CAMK-GR; Brain CA(2+)-CAlmodulin-Dependent Protein Kinase Type IV; CAMKIV; CAM Kinase-GR; CAlcium/CAlmodulin-Dependent Protein Kinase Type IV CAtalytic Chain; CAMK-GR; Brain CA
Species:
Human
Source:
Sf9 insect cells
Cat. No.: HY-P85537
Synonyms: Brain CA; 2; CAlmodulin dependent protein kinase type 4; Brain CA; 2; CAlmodulin dependent protein kinase type IV; Brain CA -CAlmodulin dependent protein kinase type IV; CAlcium / CAlmodulin dependent protein kinase type 4 CAtalytic chain; CAlcium / CAlmodulin dependent protein kinase type IV CAtalytic chain; CAlcium/CAlmodulin dependent protein kinase IV; CAlcium/CAlmodulin dependent protein kinase type IV; CAlcium/CAlmodulin-dependent protein kinase type IV; CAM kinase 4; CAM kinase GR; CAM kinase IV; CAM kinase-GR; CAMK 4; CAMK GR; CAMK IV; CAMK4; CAMKGR; IV; KCC4_HUMAN; MGC36771.
Target:
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Thiocoumarin is a carbonic anhydrase (CA) inhibitor, with Ki values of 0.047 μM, 0.042 μM, and 0.1 μM against hCA IX, mCA XIII, and hCA I, respectively; its Ki values against hCA IV, mCA XV, hCA II, hCA VA, hCA VB, hCA VI, hCA VII, hCA XII, and hCA XIV are 4.1, 4.8, 6.2, 8.4, 7.5, 8.8, 7.3, 8.7, and 7.4 μM, respectively . As a photocage molecule, Thiocoumarin undergoes photolysis upon illumination to release the caged molecule, and it exhibits red-shifted absorption properties and rapid photolysis kinetics. Thiocoumarin can be used in cancer-related research .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
