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CA IV

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Adrenergic Receptor (1) Antibiotic (1) Bacterial (1) Carbonic Anhydrase (7) Dipeptidyl Peptidase (1) Drug Metabolite (1) Small Interfering RNA (siRNA) (1)
By Research Areas:	Cancer (1) Cardiovascular Disease (1) Infection (2) Metabolic Disease (1) Neurological Disease (2)
Oligonucleotides:	Human Pre-designed siRNA Sets (1) siRNAs (1)

Inhibitors & Agonists

Recombinant Proteins

Antibodies

Oligonucleotides

Targets Recommended: Calcium Channel Glucokinase CRAC Channel Na+/Ca2+ Exchanger CaSR Calmodulin CaMK

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-W074975

CL 5343 5-Amino-1,3,4-thiadiazole-2-sulfonamide	Carbonic Anhydrase	Cancer
CL 5343 (5-Amino-1,3,4-thiadiazole-2-sulfonamide) is a selective inhibitor of carbonic anhydrase B (HCA-B) and isoforms I, II, IV, and VII. CL 5343 has a K_i of 7.9 nM for hCA II. CL 5343 acts as a CA9 ligand to achieve targeted delivery of maytansine to the cell membrane of SKRC52 renal cancer cells. CL 5343 is useful in the development of therapeutics for diseases associated with CA overactivity, such as glaucoma, epilepsy, and cancer .

HY-W424792A

O-Desmethyl Brinzolamide hydrochloride	Carbonic Anhydrase Drug Metabolite	Neurological Disease
O-Desmethyl Brinzolamide hydrochloride (compound 6a), an active metabolite of Brinzolamide, is a carbonic anhydrase (CA) inhibitor with a K_d of 0.136 nM for CA II and an IC₅₀ of 165 nM for CA IV .

HY-101136

Dealanylascamycin AT-265	Antibiotic Carbonic Anhydrase Bacterial	Infection
Dealanylascamycin (AT-265) (Compound 2) is a nucleoside antibiotic. AT 265 is a carbonic anhydrase (CA) inhibitor, with K_i values of 167, 65.2, 234, and 143 nM for hCA I, hCA II, hCA IV, and hCA IX respectively. Dealanylascamycin is the active form of Ascamycin (HY-121071). Dealanylascamycin exhibits broad-spectrum antibacterial activity and is effective against pathogenic bacteria such as Xanthomonas citri (MIC = 0.4 μg/mL). Dealanylascamycin has high cytotoxicity .

HY-151578

DPP IV/hCA II-IN-1	Dipeptidyl Peptidase Carbonic Anhydrase	Metabolic Disease
DPP IV/hCA II-IN-1 is a potent and selective dipeptidyl peptidase IV (DPP IV) and carbonic anhydrase (CA) inhibitor with an IC₅₀ value of 0.049 μM for DPP IV and with K_i values of 0.0361, 0.0428, 0.0941, 0.1328, 0.2615, and 3.034 μM for CA II, CA VB, CA VA, CA IX, CA I, and CA IV, respectively .

HY-RS01770

CA4 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
CA4 Human Pre-designed siRNA Set A contains three designed siRNAs for CA4 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

CA4 Human Pre-designed siRNA Set A CA4 Human Pre-designed siRNA Set A

HY-178030

CAXII-IN-3	Carbonic Anhydrase Adrenergic Receptor	Neurological Disease
CAXII-IN-3 is an effective carbonic anhydrase (CA XII) inhibitor with a K_i of 53 nM. CAXII-IN-3 exhibits selective inhibition against multiple human CA subtypes with K_is of 5.3 μM, 75 nM, 1.9 μM, > 10 μM against CA I, CA II, CA IV and CA IX. CAXII-IN-3 mainly inhibits CA II and XII, and reduces aqueous humor production. CAXII-IN-3 exhibits β3-AR agonistic activity, can dilate retinal blood vessels, and improve optic nerve perfusion. CAXII-IN-3 can be used in the research of ocular disorders such as glaucoma .

HY-151472

hCAIX/XII-IN-6	Carbonic Anhydrase	Infection
hCAIX/XII-IN-6 is an orally active carbonic anhydrase (CA) inhibitor. hCAIX/XII-IN-6 inhibits human CA isoforms hCA I, II, IV, IX, and XII with K_i values of 6697 nM, 2950 nM, 4093 nM, 4.1 nM and 7.7 nM, respectively. hCAIX/XII-IN-6 can be used for the research of rheumatoid arthritis (RA) .

HY-134043

Chlorthalidone Impurity G Chlorthalidone EP Impurity G	Carbonic Anhydrase	Cardiovascular Disease
Chlorthalidone Impurity G (Chlorthalidone EP Impurity G) is a potential impurity found in commercial preparations of chlorthalidone with moderate antihypertensive effects. Chlorthalidone is a thiazide diuretic that inhibits the Na+/Cl- cotransporter in the distal tubule of the kidney, thereby preventing sodium and chloride reabsorption, resulting in decreased plasma volume and cardiac output. It also inhibits carbonic anhydrase (CA), including isoenzymes CAVB, VII, IX, XII, and XIII (Kis=2.8-23 nM) and to a lesser extent CAI, CAII, IV, VA, and VI (Ki=138-1,347 nM), mediating vasodilatory activity.

Recombinant Proteins Recommended:

Carbonic Anhydrase 4 (CA IV)

Species:	Human (2) Mouse (1)
Tag:	His (3)
Source:	HEK293 (2) E. coli (1)

Cat. No.	Compare	Product Name	Species	Source	Image

HY-P72862

	Carbonic Anhydrase 4 Protein, Human (HEK293, His) CArbonic anhydrase 4; CArbonate dehydratase IV; CA-IV; CA4	Human	HEK293
	Carbonic anhydrase 4 catalyzes the reversible hydration of carbon dioxide and plays a crucial role in maintaining intracellular and extracellular pH. Carbonic Anhydrase 4 Protein, Human (HEK293, His) is the recombinant human-derived Carbonic Anhydrase 4 protein, expressed by HEK293 , with C-His labeled tag.

HY-P7720

	Carbonic Anhydrase 4 Protein, Human (His) rHuCArbonic Anhydrase 4, His; CArbonic Anhydrase 4; CArbonate Dehydratase IV; CArbonic Anhydrase IV; CA4	Human	E. coli
	Carbonic Anhydrase 4 Protein, Human (His) a recombinant Mouse Carbonic Anhydrase 4 produced in E. coli, has a His tag at the N-terminus. The Carbonic Anhydrase 4 (CA4) protein is a zinc metalloenzyme that catalyzes the reversible hydration and dehydration of CO2 and HCO3^-.

HY-P7717

	Carbonic Anhydrase 4 Protein, Mouse (HEK293, His) rMuCArbonic Anhydrase 4, His; CArbonic Anhydrase 4; CAIV; CA4; CArbonate dehydratase IV	Mouse	HEK293
	Carbonic Anhydrase 4 Protein, Mouse (HEK293, His), a recombinant human CAMK1 produced in HEK293 cells, has a His tag at the N-terminus. The Carbonic Anhydrase 4 (CA4) protein is a zinc metalloenzyme that catalyzes the reversible hydration and dehydration of CO₂ and HCO₃^-.

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Host:	Mouse (2)
Reactivity:	Human (1) human (1)
Application:	IHC-P (1) ICC/IF (1) IF-Tissue (1) IP (1) WB (2) ELISA (1)
Isotype:	IgM (1)
Conjugation:	Non-conjugated (2)
Clonality:	Monoclonal (1)
Modification:	Unmodified (2)

Cat. No.	Compare	Product Name	Application	Reactivity	Image

HY-P89928

	CA IV Antibody (YA9272)	WB, ICC/IF, IF-Tissue, IHC-P, IP, ELISA	human
	CA IV Antibody (YA9272) is a Mouse-derived and non-conjugated IgM monoclonal antibody, targeting to CA IV.

HY-P85537

	CaMKIV Antibody (YA5229) Brain CA; 2; CAlmodulin dependent protein kinase type 4; Brain CA; 2; CAlmodulin dependent protein kinase type IV; Brain CA -CAlmodulin dependent protein kinase type IV; CAlcium / CAlmodulin dependent protein kinase type 4 CAtalytic chain; CAlcium / CAlmodulin dependent protein kinase type IV CAtalytic chain; CAlcium/CAlmodulin dependent protein kinase IV; CAlcium/CAlmodulin dependent protein kinase type IV; CAlcium/CAlmodulin-dependent protein kinase type IV; CAM kinase 4; CAM kinase GR; CAM kinase IV; CAM kinase-GR; CAMK 4; CAMK GR; CAMK IV; CAMK4; CAMKGR; IV; KCC4_HUMAN; MGC36771.	WB	Human
	CaMKIV Antibody (YA5229) is a Mouse-derived and non-conjugated monoclonal antibody, targeting to CaMKIV.

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Cat. No.	Product Name		Classification

HY-RS01770

CA4 Human Pre-designed siRNA Set A		siRNAs Human Pre-designed siRNA Sets
CA4 Human Pre-designed siRNA Set A contains three designed siRNAs for CA4 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

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BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature.

BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

MedchemExpress Validation 03

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred

MedchemExpress Validation 04

MedchemExpress Validation

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