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Results for "

COX-1 selective

" in MedChemExpress (MCE) Product Catalog:

By Targets:	COX (93) Akt (2) Aldose Reductase (1) Apoptosis (16) Bacterial (1) Bcl-2 Family (1) Caspase (1) CFTR (4) Collagen (1) Endogenous Metabolite (5) Endoplasmic Reticulum Oxidoreductase 1 (ERO1) (4) Interleukin Related (3) Isotope-Labeled Compounds (12) Lipoxygenase (3) MMP (2) MOFs (1) Monoamine Oxidase (2) NF-κB (3) NO Synthase (3) p38 MAPK (2) Parasite (11) PGE synthase (7) Prostaglandin Receptor (1) Reactive Oxygen Species (ROS) (5) Reference Standards (20) SARS-CoV (1) TNF Receptor (3)
By Research Areas:	Cancer (41) Cardiovascular Disease (2) Infection (11) Inflammation/Immunology (84) Metabolic Disease (7) Neurological Disease (19)

By Targets:

COX (93)

Akt (2)

Aldose Reductase (1)

Apoptosis (16)

Bacterial (1)

Bcl-2 Family (1)

Caspase (1)

CFTR (4)

Collagen (1)

Endogenous Metabolite (5)

Endoplasmic Reticulum Oxidoreductase 1 (ERO1) (4)

Interleukin Related (3)

Isotope-Labeled Compounds (12)

Lipoxygenase (3)

MMP (2)

MOFs (1)

Monoamine Oxidase (2)

NF-κB (3)

NO Synthase (3)

p38 MAPK (2)

Parasite (11)

PGE synthase (7)

Prostaglandin Receptor (1)

Reactive Oxygen Species (ROS) (5)

Reference Standards (20)

SARS-CoV (1)

TNF Receptor (3)

By Research Areas:

Cancer (41)

Cardiovascular Disease (2)

Infection (11)

Inflammation/Immunology (84)

Metabolic Disease (7)

Neurological Disease (19)

104

Inhibitors & Agonists

Bibliotecas de Screening

Natural
Products

Isotope-Labeled Compounds

Targets Recommended: COX

Cat. No.	Nombre del producto	Target	Áreas de investigación	Chemical Structure

HY-78131

Ibuprofen Maximum Cited Publications 22 Publications Verification (±)-Ibuprofen	COX Apoptosis Parasite	Infection Neurological Disease Inflammation/Immunology Cancer
Ibuprofen ((±)-Ibuprofen) is a potent, orally active, selective *COX-1* inhibitor with an IC₅₀ value of 13 μM. Ibuprofen inhibits cell proliferation, angiogenesis, and induces cell apoptosis. Ibuprofen is a nonsteroidal anti-inflammatory agent and a nitric oxide (NO) donor. Ibuprofen ((±)-Ibuprofen) can be used in the research of pain, swelling, inflammation, infection, immunology, cancers .

HY-B0363

Nimesulide 5+ Cited Publications R805	COX	Inflammation/Immunology Cancer
Nimesulide is a selective *COX-2* inhibitor, with IC₅₀s of 70 nM-70 μM in a time-dependent manner, but it shows no effect on COX-1 (IC₅₀ >100 μM). Nimesulide has potent anti-inflammatory, analgesic and antipyretic properties.

HY-111310

ML351 2 Publications Verification	Lipoxygenase	Neurological Disease Metabolic Disease
ML351 is a potent and highly specific 15-LOX-1 inhibitor with an IC₅₀ of 200 nM. ML351 shows excellent selectivity (>250-fold) versus the related isozymes, 5-LOX, platelet 12-LOX, 15-LOX-2, ovine COX-1, and human COX-2 . ML351 prevents dysglycemia and reduces β-cell oxidative stress in nonobese diabetic mouse model of T1D .

HY-59105

SC-560 3 Publications Verification	COX	Cancer
SC-560 is a potent and selective *COX-1* inhibitor with an IC₅₀ of 9 nM.

HY-17372

Rofecoxib 5 Publications Verification MK 966	COX	Inflammation/Immunology Cancer
Rofecoxib is a potent, specific and orally active *COX-2* inhibitor, with IC₅₀s of 26 and 18 nM for human COX-2 in human osteosarcoma cells and Chinese hamster ovary cells, with a 1000-fold selectivity for COX-2 over human COX-1 (IC₅₀ > 50 μM in U937 cells and > 15 μM in Chinese hamster ovary cells).

HY-15762

Valdecoxib 5 Publications Verification SC 65872	COX Endogenous Metabolite	Inflammation/Immunology Cancer
Valdecoxib is a highly potent and selective inhibitor of *COX-2, with IC₅₀s of 5 nM and 140 μM for COX-2 and COX-1*, respeceively. Valdecoxib can be used in the research of arthritis and pain.

HY-13913

NS-398 15+ Cited Publications	COX	Inflammation/Immunology Cancer
NS-398 is a non-steroidal an-inflammatory agent with analgesic and antipyretic effects, and selectively inhibits prostaglandin G/H synthase 2/cyclooxygenase 2 (COX-2) activity, with an IC₅₀ of 3.8 μM, and has no effect on COX-1 at 100 μM.

HY-78131C

Ibuprofen sodium Maximum Cited Publications 22 Publications Verification (±)-Ibuprofen sodium	COX Apoptosis Parasite	Infection Neurological Disease Inflammation/Immunology Cancer
Ibuprofen ((±)-Ibuprofen) sodium is an orally active, selective *COX-1* inhibitor with an IC₅₀ value of 13 μM. Ibuprofen sodium inhibits cell proliferation, angiogenesis, and induces cell apoptosis. Ibuprofen sodium is a nonsteroidal anti-inflammatory agent and a nitric oxide (NO) donor. Ibuprofen sodium can be used in the research of pain, swelling, inflammation, infection, immunology, cancers .

HY-B1153

Glafenine 4 Publications Verification Glafenin	COX CFTR Apoptosis Endoplasmic Reticulum Oxidoreductase 1 (ERO1)	Metabolic Disease Inflammation/Immunology
Glafenine (Glafenin) is a non-selective, non-steroidal anti-inflammatory drug-based *COX-1/COX-2* inhibitor. Glafenine exerts anti-inflammatory, anti-proliferative and anti-cell migration effects by inhibiting the arachidonic acid metabolic pathway and reducing prostaglandin synthesis. Glafenine can induce cell cycle arrest in vascular smooth muscle cells and endothelial cells and reduce the synthesis of the extracellular matrix protein Tenascin. Glafenine can be used in the research of inflammatory-related diseases, vascular restenosis and cystic fibrosis (CF) .

HY-118827

Vedaprofen Quadrisol; CERM 10202; PM 150	COX	Inflammation/Immunology
Vedaprofen (Quadrisol) is a *COX-1* selective nonsteroidal anti-inflammatory agent (NSAID) for serum TxB2 and exudate PGE2 inhibition . Vedaprofen is a Escherichia coli (E. coli) sliding clamp (SC) inhibitor with the IC₅₀ of 222 μM .

HY-15321

Etoricoxib MK-0663; L-791456	COX	Inflammation/Immunology Cancer
Etoricoxib (MK-0663) is a non steroidal anti-inflammatory agent, acting as a selective and orally active *COX-2* inhibitor. Etoricoxib can cross the blood-brain barrier, with IC₅₀s of 1.1 μM and 116 μM for *COX-2* and *COX-1* in human whole blood .

HY-B0335

Tolfenamic Acid 2 Publications Verification GEA 6414	COX	Infection Neurological Disease Inflammation/Immunology Cancer
Tolfenamic Acid (GEA 6414) is a CNS-penetrant non-steroidal anti-inflammatory and anti-cancer agent, selectively inhibits *COX-2, with an IC₅₀* of 13.49 μM (3.53 μg/mL) in LPS-treated (COX-2) canine DH82 monocyte/macrophage cells, but shows no effect on COX-1.

HY-114200

Imrecoxib BAP-909	COX	Inflammation/Immunology
Imrecoxib (BAP-909) is a novel and selective cyclooxygenase 2 (COX-2) inhibitor with an IC₅₀ value of 18 nM, it also inhibits COX1- activity with an IC₅₀ value of 115 nM. Imrecoxib (BAP-909) has anti-inflammatory effect .

HY-N0396

Harpagoside 4 Publications Verification	COX NO Synthase	Inflammation/Immunology Cancer
Harpagoside can be obtained by Harpagophytum procumbens, which has anti-inflammatory, anti-cancer, protective activity, and efficacy. Harpagoside has an inhibitory effect on *COX-1* and *COX-2* active, and suppresses NO production. Harpagoside inhibits HepG2 cell lipid polysaccharide, which is a protein that is expressed horizontally and selectively, and has anti-inflammatory and latent pain effects. Harpagoside has the ability to protect the body, and has a degenerative effect on the β-oxidation (Aβ).

HY-N0929

Hexahydrocurcumin	COX Reactive Oxygen Species (ROS)	Cancer
Hexahydrocurcumin is one of the major metabolites of curcumin and a selective, orally active *COX-2* inhibitor. Hexahydrocurcumin is inactive against COX-1. Hexahydrocurcumin has antioxidant, anticancer and anti-inflammatory activities .

HY-14670

Firocoxib ML 1785713	COX	Inflammation/Immunology
Firocoxib (ML 1785713) is a potent, selective and orally active *COX-2* inhibitor with an IC₅₀ of 0.13 μM. Firocoxib shows 58-fold more selective for *COX-2* than COX-1 (IC₅₀ of 7.5 μM). Firocoxib has anti-inflammatory effects .

HY-N0389

Columbin 1 Publications Verification	COX Parasite	Inflammation/Immunology
Columbin is an orally active diterpenoid furanolactone from Calumbae radix, has anti-inflammatory and anti-trypanosomal effects. Columbin selectively inhibits *COX-2* (EC₅₀=53.1 μM) over COX-1 (EC₅₀=327 μM) .

HY-10439

HPGDS inhibitor 1	PGE synthase	Inflammation/Immunology
HPGDS inhibitor 1 is a potent, selective and orally active Hematopoietic Prostaglandin D Synthase (HPGDS) inhibitor with an IC₅₀s of 0.6 nM and 32 nM in enzyme and cellular assays, respectively. HPGDS inhibitor 1 does not inhibit human L-PGDS, mPGES, COX-1, COX-2, or 5-LOX .

HY-120824

Mofezolac 2 Publications Verification	COX	Inflammation/Immunology
Mofezolac, a non-steroidal anti-inflammatory drug (NSAID), is a selective, reversible and orally active *COX-1* inhibitor with an IC₅₀ of 1.44 nM. Mofezolac shows weak inhibitory activity on COX-2 (IC₅₀ of 447 nM). Mofezolac can relieve pain and has anti-inflammatory activities .

HY-108259

HQL-79	PGE synthase	Inflammation/Immunology
HQL-79, a potent, selective and orally active human hematopoietic prostaglandin D synthase (H-PGDS) inhibitor, highly selectively inhibits the synthesis of PGD₂, and acts as an anti-allergic agent, with a K_d of 0.8 μM and an IC₅₀ of 6 μM. Shows no obvious effect on COX-1, COX-2, m-PGES, or L-PGDS .

HY-121537

CAY10404	COX Akt Apoptosis	Neurological Disease Inflammation/Immunology Cancer
CAY10404 is a potent and selective cyclooxygenase-2 (COX-2) inhibitor with an IC₅₀ of 1 nM and a selectivity index (SI; COX-1 IC₅₀/COX-2 IC₅₀) of >500000. CAY10404 is a potent PKB/Akt and MAPK signaling pathways inhibitor and induces apoptosis in non-small cell lung cancer (NSCLC) cells. CAY10404, a diarylisoxazole, has good analgesic, anti-inflammatory, and anti-cancer activities .

HY-112731

TFAP N-(5-Aminopyridin-2-yl)-4-(trifluoromethyl)benzamide	COX Endogenous Metabolite	Metabolic Disease
TFAP is a selective cyclooxygenase-1 *(COX-1)* inhibitor, with an IC₅₀ of 0.8 μM.

HY-19384

Enflicoxib E 6087	COX	Inflammation/Immunology
Enflicoxib (E 6087) is a nonsteroidal anti-inflammatory compound that selectively inhibits cyclooxygenase-2 (COX-2).?Enflicoxib does not inhibit cyclooxygenase-1 (COX-1). E-6087 shows anti-inflammatory, analgesic and antipyretic activities in animal models .

HY-103387

DuP-697 1 Publications Verification	COX Apoptosis	Inflammation/Immunology Cancer
DuP-697 is a member of the vicinal diaryl heterocycles and a potent, irreversible, selective and orally active *COX-2* inhibitor (IC₅₀ of 10 nM and 800 nM for human *COX-2* and *COX-1, respectively). DuP-697 exerts antiproliferative (IC₅₀* of 42.8 nM), antiangiogenic and apoptotic effects on HT29 colorectal cancer cells. DuP-697 inhibits prostaglandin synthesis and has anti-inflammatory, anticancer and antipyretic effects .

HY-B1153A

Glafenine hydrochloride 4 Publications Verification Glafenin hydrochloride	COX CFTR Apoptosis Endoplasmic Reticulum Oxidoreductase 1 (ERO1)	Metabolic Disease Inflammation/Immunology
Glafenine (Glafenin) hydrochloride is a non-selective, non-steroidal anti-inflammatory drug-based *COX-1/COX-2* inhibitor. Glafenine hydrochloride exerts anti-inflammatory, anti-proliferative and anti-cell migration effects by inhibiting the arachidonic acid metabolic pathway and reducing prostaglandin synthesis. Glafenine hydrochloride can induce cell cycle arrest in vascular smooth muscle cells and endothelial cells and reduce the synthesis of the extracellular matrix protein Tenascin. Glafenine hydrochloride can be used in the research of inflammatory-related diseases, vascular restenosis and cystic fibrosis (CF) .

HY-15321S

Etoricoxib-d4 1 Publications Verification MK-0663-d₄; L-791456-d₄	COX	Others
Etoricoxib-d₄ (MK-0663-d₄) is a deuterium labeled Etoricoxib. Etoricoxib is a non steroidal anti-inflammatory agent, acting as a selective and orally active COX-2 inhibitor, with IC50s of 1.1 μM and 116 μM for COX-2 and COX-1 in human whole blood.

HY-78131R

Ibuprofen (Standard) (±)-Ibuprofen (Standard)	MOFs	Infection Neurological Disease Inflammation/Immunology Cancer
Ibuprofen (Standard) is the analytical standard of Ibuprofen. This product is intended for research and analytical applications. Ibuprofen ((±)-Ibuprofen) is a potent, orally active, selective *COX-1* inhibitor with an IC₅₀ value of 13 μM. Ibuprofen inhibits cell proliferation, angiogenesis, and induces cell apoptosis. Ibuprofen is a nonsteroidal anti-inflammatory agent and a nitric oxide (NO) donor. Ibuprofen ((±)-Ibuprofen) can be used in the research of pain, swelling, inflammation, infection, immunology, cancers .

HY-121585

CAY10698	Lipoxygenase	Inflammation/Immunology
CAY10698 (compound 1) is a potent and selective inhibitor of 12-Lipoxygenase (12-LOX) with an IC₅₀ of 5.1 μM. CAY10698 is inactive against 5-LOX, 15-LOX-1, 15-LOX-2 and COX-1/2 .

HY-B1153R

Glafenine (Standard) Glafenin (Standard)	COX CFTR Apoptosis Endoplasmic Reticulum Oxidoreductase 1 (ERO1) Reference Standards	Metabolic Disease Inflammation/Immunology
Glafenine (Standard) is the analytical standard of Glafenine. This product is intended for research and analytical applications. Glafenine (Glafenin) is a non-selective, non-steroidal anti-inflammatory drug-based COX-1/COX-2 inhibitor. Glafenine exerts anti-inflammatory, anti-proliferative and anti-cell migration effects by inhibiting the arachidonic acid metabolic pathway and reducing prostaglandin synthesis. Glafenine can induce cell cycle arrest in vascular smooth muscle cells and endothelial cells and reduce the synthesis of the extracellular matrix protein Tenascin. Glafenine can be used in the research of inflammatory-related diseases, vascular restenosis and cystic fibrosis (CF) .

HY-100586

Ibuprofen L-lysine Maximum Cited Publications 22 Publications Verification (±)-Ibuprofen L-lysine	COX Apoptosis Parasite	Infection Inflammation/Immunology Cancer
Ibuprofen ((±)-Ibuprofen) L-lysine is a potent orally active, selective *COX-1* inhibitor with an IC₅₀ value of 13 μM. Ibuprofen L-lysine inhibits cell proliferation, angiogenesis, and induces cell apoptosis. Ibuprofen L-lysine is a nonsteroidal anti-inflammatory agent and a nitric oxide (NO) donor. Ibuprofen L-lysine can be used in the research of pain, swelling, inflammation, infection, immunology, cancers .

HY-78131CS

Ibuprofen-d3 sodium 1 Publications Verification (±)-Ibuprofen-d3 sodium	Apoptosis COX Isotope-Labeled Compounds Parasite	Infection Neurological Disease Inflammation/Immunology Cancer
Ibuprofen-d₃ ((±)-Ibuprofen-d₃) sodium is the deuterium labeled Ibuprofen sodium (HY-78131C). Ibuprofen sodium is an orally active, selective *COX-1* inhibitor with an IC₅₀ value of 13 μM. Ibuprofen sodium inhibits cell proliferation, angiogenesis, and induces cell apoptosis. Ibuprofen sodium is a nonsteroidal anti-inflammatory agent and a nitric oxide (NO) donor. Ibuprofen sodium can be used in the research of pain, swelling, inflammation, infection, immunology, cancers .

HY-78131S3

Ibuprofen-13C6 (±)-Ibuprofen-¹³C₆	Isotope-Labeled Compounds Apoptosis Parasite COX	Cancer
Ibuprofen- ¹³C₆ ((±)-Ibuprofen- ¹³C₆) is a ¹³C labeled Ibuprofen (HY-78131). Ibuprofen ((±)-Ibuprofen) is a potent, orally active, selective *COX-1* inhibitor with an IC₅₀ value of 13 μM. Ibuprofen inhibits cell proliferation, angiogenesis, and induces cell apoptosis. Ibuprofen is a nonsteroidal anti-inflammatory agent and a nitric oxide (NO) donor. Ibuprofen ((±)-Ibuprofen) can be used in the research of pain, swelling, inflammation, infection, immunology, cancers .

HY-N1965

Gaultherin	NF-κB p38 MAPK COX Monoamine Oxidase MMP Interleukin Related TNF Receptor Reactive Oxygen Species (ROS)	Metabolic Disease Inflammation/Immunology
Gaultherin is an orally active non-steroidal anti-inflammatory agent. Gaultherin selectively inhibits NF-κB, MAPK, *COX-2* (IC₅₀ = 0.35 mg/mL), LOX (IC₅₀ = 0.56 mg/mL) and HYAL (IC₅₀ = 28.58 μg/mL) to exert anti-inflammatory, antipyretic and analgesic effects. Gaultherin exhibits modest direct antioxidant capacity, greater in cell-based models. Gaultherin does not affect COX-1 so that avoids the common gastrointestinal side effects of Aspirin (HY-14654) .

HY-N0929R

Hexahydrocurcumin (Standard)	Reference Standards COX Reactive Oxygen Species (ROS)	Cancer
Hexahydrocurcumin (Standard) is the analytical standard of Hexahydrocurcumin. This product is intended for research and analytical applications. Hexahydrocurcumin is one of the major metabolites of curcumin and a selective, orally active COX-2 inhibitor. Hexahydrocurcumin is inactive against COX-1. Hexahydrocurcumin has antioxidant, anticancer and anti-inflammatory activities .

HY-B0335R

Tolfenamic Acid (Standard) GEA 6414 (Standard)	Reference Standards COX	Inflammation/Immunology Cancer
Tolfenamic Acid (Standard) is the analytical standard of Tolfenamic Acid. This product is intended for research and analytical applications. Tolfenamic Acid (GEA 6414) is a non-steroidal anti-inflammatory and anti-cancer agent, selectively inhibits *COX-2, with an IC₅₀* of 13.49 μM (3.53 μg/mL) in LPS-treated (COX-2) canine DH82 monocyte/macrophage cells, but shows no effect on COX-1.

HY-162167

COX-1-IN-1	COX	Cardiovascular Disease Neurological Disease
COX-1-IN-1 (compound 15a) is a selective inhibitor for cyclooxygenase (COX), with IC₅₀s of 0.23 μM (COX-1) and >50 μM (COX-2), selective index (COX-2 IC₅₀/COX-1 IC₅₀) is 217. COX-1-IN-1 inhibits platelet aggregation .

HY-136720

ZXX2-77	COX	Others
ZXX2-77 is a cyclooxygenase-1 (COX-1) selective inhibitor belonging to the benzenesulfonylanilide class of compounds. It is reported as a novel analgesic that does not cause gastric damage. ZXX2-77 has a weak analgesic effect but exhibits potent COX-1 inhibitory activity in vitro. The low oral absorption rate of ZXX2-77 leads to its weak analgesic effect in vivo. At a dose of 30 mg/kg, the maximum plasma concentration of ZXX2-77 (1.2 mM) did not reach its COX-1 IC50 value (3.2 mM). In contrast, its derivative ZXX2-79, although weaker in vitro COX inhibitory activity, is better absorbed, exhibits stronger analgesic effect and hardly causes gastric damage. These findings suggest that ZXX2-77 and its derivatives as COX-1 selective inhibitors may become effective analgesics that do not cause gastric damage.

HY-103386

FR122047	COX	Inflammation/Immunology
FR122047 (hydrochloride) is a selective and oral active inhibitor of *COX-1* with an IC₅₀ of 28 nM. FR122047 hydrochloride has antiplatelet, analgesic and anti-inflammatory effects in vivo .

HY-134753

Teriflunomide impurity 3 4-Amino-N-(4-trifluoromethylphenyl)benzamide	COX	Inflammation/Immunology
Teriflunomide impurity 3 (4-Amino-N-(4-trifluoromethylphenyl)benzamide) is a selective *COX-1* inhibitor with an IC₅₀ of 30 µM. Teriflunomide impurity 3 is less active against COX-2 (IC₅₀>100 µM) .

HY-14670S

Firocoxib-d4	Isotope-Labeled Compounds COX	Inflammation/Immunology
Firocoxib-d₄ (ML 1785713-d₄) is the deuterium labeled Firocoxib. Firocoxib (ML 1785713) is a potent, selective and orally active COX-2 inhibitor with an IC₅₀ of 0.13 μM. Firocoxib shows 58-fold more selective for COX-2 than COX-1 (IC₅₀ of 7.5 μM). Firocoxib has anti-inflammatory effects .

HY-15321S2

Etoricoxib-d3 MK-0663-d₃; L-791456-d₃	COX	Inflammation/Immunology
Etoricoxib-d₃ is the deuterium labeled Etoricoxib . Etoricoxib (MK-0663) is a non steroidal anti-inflammatory agent, acting as a selective and orally active COX-2 inhibitor, with IC₅₀s of 1.1 μM and 116 μM for COX-2 and COX-1 in human whole blood .

HY-15321R

Etoricoxib (Standard) MK-0663 (Standard); L-791456 (Standard)	Reference Standards COX	Inflammation/Immunology Cancer
Etoricoxib (Standard) is the analytical standard of Etoricoxib. This product is intended for research and analytical applications. Etoricoxib (MK-0663) is a non steroidal anti-inflammatory agent, acting as a selective and orally active *COX-2* inhibitor, with IC₅₀s of 1.1 μM and 116 μM for COX-2 and COX-1 in human whole blood.

HY-B0335S1

Tolfenamic acid-13C6 GEA 6414-¹³C₆	Isotope-Labeled Compounds COX	Inflammation/Immunology Cancer
Tolfenamic acid- ¹³C₆ is the ¹³C₆ labeled Tolfenamic acid. Tolfenamic Acid (GEA 6414) is a non-steroidal anti-inflammatory and anti-cancer agent, selectively inhibits COX-2, with an IC50 of 13.49 μM (3.53 μg/mL) in LPS-treated (COX-2) canine DH82 monocyte/macrophage cells, but shows no effect on COX-1.

HY-19384R

Enflicoxib (Standard) E 6087 (Standard)	COX Reference Standards	Inflammation/Immunology
Enflicoxib (Standard) is the analytical standard of Enflicoxib. This product is intended for research and analytical applications. Enflicoxib (E 6087) is a nonsteroidal anti-inflammatory compound that selectively inhibits cyclooxygenase-2 (COX-2). Enflicoxib does not inhibit cyclooxygenase-1 (COX-1). E-6087 shows anti-inflammatory, analgesic and antipyretic activities in animal models .

HY-N0389R

Columbin (Standard)	Reference Standards COX Parasite	Inflammation/Immunology
Columbin (Standard) is the analytical standard of Columbin. This product is intended for research and analytical applications. Columbin is an orally active diterpenoid furanolactone from Calumbae radix, has anti-inflammatory and anti-trypanosomal effects. Columbin selectively inhibits COX-2 (EC50=53.1 μM) over COX-1 (EC50=327 μM) .

HY-150550

COX-2-IN-26	COX	Inflammation/Immunology
COX-2-IN-26 is a potent, selective and orally active *COX-2* inhibitor with IC₅₀ values of 10.61, 0.067, 1.96 µM for COX-1, COX-2, 15-LOX, respectively. COX-2-IN-26 shows anti-inflammatory activity. COX-2-IN-26 shows gastrointestinal safety profile .

HY-78131CR

Ibuprofen sodium (Standard) (±)-Ibuprofen sodium (Standard)	COX Apoptosis Parasite Reference Standards	Infection Neurological Disease Inflammation/Immunology Cancer
Ibuprofen (sodium) (Standard) is the analytical standard of Ibuprofen (sodium). This product is intended for research and analytical applications. Ibuprofen ((±)-Ibuprofen) sodium is an orally active, selective COX-1 inhibitor with an IC50 value of 13 μM. Ibuprofen sodium inhibits cell proliferation, angiogenesis, and induces cell apoptosis. Ibuprofen sodium is a nonsteroidal anti-inflammatory agent and a nitric oxide (NO) donor. Ibuprofen sodium can be used in the research of pain, swelling, inflammation, infection, immunology, cancers .

HY-78131S2

Ibuprofen-d4	Isotope-Labeled Compounds COX Apoptosis Parasite	Infection Neurological Disease Inflammation/Immunology Cancer
Ibuprofen-d₄ is a deuterium labeled Ibuprofen (HY-78131). Ibuprofen is a potent, orally active, selective COX-1 inhibitor with an IC₅₀ value of 13 μM. Ibuprofen inhibits cell proliferation, angiogenesis, and induces cell apoptosis. Ibuprofen is a nonsteroidal anti-inflammatory agent and a nitric oxide (NO) donor. Ibuprofen ((±)-Ibuprofen) can be used in the research of pain, swelling, inflammation, infection, immunology, cancers .

HY-17372S

Rofecoxib-d5	Isotope-Labeled Compounds COX	Inflammation/Immunology Cancer
Rofecoxib-d₅ is the deuterium labeled Rofecoxib. Rofecoxib is a potent, specific and orally active COX-2 inhibitor, with IC₅₀s of 26 and 18 nM for human COX-2 in human osteosarcoma cells and Chinese hamster ovary cells, with a 1000-fold selectivity for COX-2 over human COX-1 (IC₅₀ > 50 μM in U937 cells and > 15 μM in Chinese hamster ovary cells) .

HY-179125

COX-2-IN-59	COX Bcl-2 Family Caspase Apoptosis	Cancer
COX-2-IN-59 is a potent and selective *COX-2* inhibitor with an IC₅₀ of 0.052 μM. COX-2-IN-59 exhibits 200-fold selectivity over COX-1 (IC₅₀ = 11.16 μM). COX-2-IN-59 reduces COX-2 levels, induces cell cycle arrest, and triggers apoptosis by increasing Bax expression, decreasing Bcl-2 levels, and activating caspase-3. COX-2-IN-59 can be used for the research of colon cancer .

Cat. No.	Nombre del producto

HY-L130

Non-steroidal Anti-Inflammatory Compound Library

627 compounds

Non-steroidal anti-inflammatory drugs (NSAIDs) are members of a therapeutic drug class with potent anti-inflammatory, analgesic and antipyretic activity, and are among the most widely used drugs worldwide. The most prominent NSAIDs are aspirin, ibuprofen, and naproxen.

The main mechanism of action of NSAIDs is the inhibition of the enzyme cyclooxygenase (COX), based on which NSAIDs can be classified into two types: non-selective and COX-2 selective. Most NSAIDs are non-selective and inhibit both COX-1 and COX-2 activity.

MCE offers a unique collection of 627 non-steroidal compounds with identified anti-inflammatory activity. MCE non-steroidal anti-inflammatory library is a useful tool for the study of anti-inflammatory drugs and pharmacology.

Cat. No.	Nombre del producto	Category	Target	Chemical Structure

HY-15762

Valdecoxib 5 Publications Verification SC 65872	Productos naturales Classification of Application Fields Endogenous metabolite Inflammation/Immunology Disease Research Fields Source Classification	COX Endogenous Metabolite
Valdecoxib is a highly potent and selective inhibitor of *COX-2, with IC₅₀s of 5 nM and 140 μM for COX-2 and COX-1*, respeceively. Valdecoxib can be used in the research of arthritis and pain.

HY-N0396

Harpagoside 4 Publications Verification	Iridoids Classification of Application Fields Terpenoids Pedaliaceae Plants Harpagophytum procumbens Inflammation/Immunology Disease Research Fields	COX NO Synthase
Harpagoside can be obtained by Harpagophytum procumbens, which has anti-inflammatory, anti-cancer, protective activity, and efficacy. Harpagoside has an inhibitory effect on *COX-1* and *COX-2* active, and suppresses NO production. Harpagoside inhibits HepG2 cell lipid polysaccharide, which is a protein that is expressed horizontally and selectively, and has anti-inflammatory and latent pain effects. Harpagoside has the ability to protect the body, and has a degenerative effect on the β-oxidation (Aβ).

HY-N0929

Hexahydrocurcumin	Classification of Application Fields Phenols Polyphenols Plants Curcuma longa Disease Research Fields Source Classification Zingiberaceae Cancer	COX Reactive Oxygen Species (ROS)
Hexahydrocurcumin is one of the major metabolites of curcumin and a selective, orally active *COX-2* inhibitor. Hexahydrocurcumin is inactive against COX-1. Hexahydrocurcumin has antioxidant, anticancer and anti-inflammatory activities .

HY-N0389

Columbin 1 Publications Verification	other families Classification of Application Fields Terpenoids Diterpenoids Plants Inflammation/Immunology Disease Research Fields Source Classification	COX Parasite
Columbin is an orally active diterpenoid furanolactone from Calumbae radix, has anti-inflammatory and anti-trypanosomal effects. Columbin selectively inhibits *COX-2* (EC₅₀=53.1 μM) over COX-1 (EC₅₀=327 μM) .

HY-112731

TFAP N-(5-Aminopyridin-2-yl)-4-(trifluoromethyl)benzamide	Productos naturales Classification of Application Fields Metabolic Disease Endogenous metabolite Disease Research Fields Source Classification	COX Endogenous Metabolite
TFAP is a selective cyclooxygenase-1 *(COX-1)* inhibitor, with an IC₅₀ of 0.8 μM.

HY-N1965

Gaultherin	other families Classification of Application Fields Ketones, Aldehydes, Acids Gaultheria yunnanensis Ericaceae Plants Inflammation/Immunology Disease Research Fields Source Classification	NF-κB p38 MAPK COX Monoamine Oxidase MMP Interleukin Related TNF Receptor Reactive Oxygen Species (ROS)
Gaultherin is an orally active non-steroidal anti-inflammatory agent. Gaultherin selectively inhibits NF-κB, MAPK, *COX-2* (IC₅₀ = 0.35 mg/mL), LOX (IC₅₀ = 0.56 mg/mL) and HYAL (IC₅₀ = 28.58 μg/mL) to exert anti-inflammatory, antipyretic and analgesic effects. Gaultherin exhibits modest direct antioxidant capacity, greater in cell-based models. Gaultherin does not affect COX-1 so that avoids the common gastrointestinal side effects of Aspirin (HY-14654) .

HY-N0929R

Hexahydrocurcumin (Standard)	Structural Classification Phenols Polyphenols Plants Curcuma longa Source Classification Zingiberaceae	Reference Standards COX Reactive Oxygen Species (ROS)
Hexahydrocurcumin (Standard) is the analytical standard of Hexahydrocurcumin. This product is intended for research and analytical applications. Hexahydrocurcumin is one of the major metabolites of curcumin and a selective, orally active COX-2 inhibitor. Hexahydrocurcumin is inactive against COX-1. Hexahydrocurcumin has antioxidant, anticancer and anti-inflammatory activities .

HY-N0389R

Columbin (Standard)	Structural Classification other families Terpenoids Diterpenoids Plants Source Classification	Reference Standards COX Parasite
Columbin (Standard) is the analytical standard of Columbin. This product is intended for research and analytical applications. Columbin is an orally active diterpenoid furanolactone from Calumbae radix, has anti-inflammatory and anti-trypanosomal effects. Columbin selectively inhibits COX-2 (EC50=53.1 μM) over COX-1 (EC50=327 μM) .

HY-N3631

Ethoxycoronarin D	Hedychium coronarium Koen. Classification of Application Fields Terpenoids Diterpenoids Plants Disease Research Fields Inflammation/Immunology Source Classification Zingiberaceae	COX
Ethoxycoronarin D is a labdane diterpenes compound isolated from rhizomes. Ethoxycoronarin D selectively inhibits COX-1 with an IC₅₀ of 3.8 µM .

HY-N3632

Methoxycoronarin D Coronarin D Me ether	Hedychium coronarium Koen. Terpenoids Diterpenoids Plants Source Classification Zingiberaceae	NF-κB COX
Methoxycoronarin D can be isolated from Hedychium coronarium J. Koenig and is a potent inhibitor of NF-κB with an IC₅₀ value of 7.3 μM. Methoxycoronarin D is also a selective inhibitor of *COX-1* with an IC₅₀ value of 0.9 μM .

HY-15762R

Valdecoxib (Standard) SC 65872 (Standard)	Structural Classification Productos naturales Endogenous metabolite Source Classification	Reference Standards COX Endogenous Metabolite
Valdecoxib (Standard) is the analytical standard of Valdecoxib. This product is intended for research and analytical applications. Valdecoxib is a highly potent and selective inhibitor of *COX-2, with IC₅₀s of 5 nM and 140 μM for COX-2 and COX-1*, respeceively. Valdecoxib can be used in the research of arthritis and pain.

HY-N0396R

Harpagoside (Standard)	Structural Classification Iridoids Terpenoids Pedaliaceae Plants Harpagophytum procumbens	Reference Standards COX NO Synthase
Harpagoside (Standard) is the analytical standard of Harpagoside. This product is intended for research and analytical applications. Harpagoside can be obtained by Harpagophytum procumbens, which has anti-inflammatory, anti-cancer, protective activity, and efficacy. Harpagoside has an inhibitory effect on COX-1 and COX-2 active, and suppresses NO production. Harpagoside inhibits HepG2 cell lipid polysaccharide, which is a protein that is expressed horizontally and selectively, and has anti-inflammatory and latent pain effects. Harpagoside has the ability to protect the body, and has a degenerative effect on the β-oxidation (Aβ) .

HY-N1965R

Gaultherin (Standard)	Structural Classification other families Ketones, Aldehydes, Acids Gaultheria yunnanensis Ericaceae Plants Source Classification	Reference Standards NF-κB p38 MAPK COX Reactive Oxygen Species (ROS) Monoamine Oxidase MMP Interleukin Related TNF Receptor
Gaultherin (Standard) is the analytical standard for Gaultherin (HY-N1965). Gaultherin is an orally active non-steroidal anti-inflammatory agent. Gaultherin selectively inhibits NF-κB, MAPK, *COX-2* (IC₅₀ = 0.35 mg/mL), LOX (IC₅₀ = 0.56 mg/mL) and HYAL (IC₅₀ = 28.58 μg/mL) to exert anti-inflammatory, antipyretic and analgesic effects. Gaultherin exhibits modest direct antioxidant capacity, greater in cell-based models. Gaultherin does not affect COX-1 so that avoids the common gastrointestinal side effects of Aspirin (HY-14654) .

Cat. No.	Nombre del producto	Chemical Structure

HY-15321S

Etoricoxib-d4 1 Publications Verification
Etoricoxib-d₄ (MK-0663-d₄) is a deuterium labeled Etoricoxib. Etoricoxib is a non steroidal anti-inflammatory agent, acting as a selective and orally active COX-2 inhibitor, with IC50s of 1.1 μM and 116 μM for COX-2 and COX-1 in human whole blood.

HY-78131CS

Ibuprofen-d3 sodium

1 Publications Verification

Ibuprofen-d₃ ((±)-Ibuprofen-d₃) sodium is the deuterium labeled Ibuprofen sodium (HY-78131C). Ibuprofen sodium is an orally active, selective COX-1 inhibitor with an IC₅₀ value of 13 μM. Ibuprofen sodium inhibits cell proliferation, angiogenesis, and induces cell apoptosis. Ibuprofen sodium is a nonsteroidal anti-inflammatory agent and a nitric oxide (NO) donor. Ibuprofen sodium can be used in the research of pain, swelling, inflammation, infection, immunology, cancers .

HY-78131S3

Ibuprofen-13C6

Ibuprofen- ¹³C₆ ((±)-Ibuprofen- ¹³C₆) is a ¹³C labeled Ibuprofen (HY-78131). Ibuprofen ((±)-Ibuprofen) is a potent, orally active, selective COX-1 inhibitor with an IC₅₀ value of 13 μM. Ibuprofen inhibits cell proliferation, angiogenesis, and induces cell apoptosis. Ibuprofen is a nonsteroidal anti-inflammatory agent and a nitric oxide (NO) donor. Ibuprofen ((±)-Ibuprofen) can be used in the research of pain, swelling, inflammation, infection, immunology, cancers .

HY-14670S

Firocoxib-d4
Firocoxib-d₄ (ML 1785713-d₄) is the deuterium labeled Firocoxib. Firocoxib (ML 1785713) is a potent, selective and orally active COX-2 inhibitor with an IC₅₀ of 0.13 μM. Firocoxib shows 58-fold more selective for COX-2 than COX-1 (IC₅₀ of 7.5 μM). Firocoxib has anti-inflammatory effects .

HY-15321S2

Etoricoxib-d3
Etoricoxib-d₃ is the deuterium labeled Etoricoxib . Etoricoxib (MK-0663) is a non steroidal anti-inflammatory agent, acting as a selective and orally active COX-2 inhibitor, with IC₅₀s of 1.1 μM and 116 μM for COX-2 and COX-1 in human whole blood .

HY-B0335S1

Tolfenamic acid-13C6
Tolfenamic acid- ¹³C₆ is the ¹³C₆ labeled Tolfenamic acid. Tolfenamic Acid (GEA 6414) is a non-steroidal anti-inflammatory and anti-cancer agent, selectively inhibits COX-2, with an IC50 of 13.49 μM (3.53 μg/mL) in LPS-treated (COX-2) canine DH82 monocyte/macrophage cells, but shows no effect on COX-1.

HY-78131S2

Ibuprofen-d4

Ibuprofen-d₄ is a deuterium labeled Ibuprofen (HY-78131). Ibuprofen is a potent, orally active, selective COX-1 inhibitor with an IC₅₀ value of 13 μM. Ibuprofen inhibits cell proliferation, angiogenesis, and induces cell apoptosis. Ibuprofen is a nonsteroidal anti-inflammatory agent and a nitric oxide (NO) donor. Ibuprofen ((±)-Ibuprofen) can be used in the research of pain, swelling, inflammation, infection, immunology, cancers .

HY-17372S

Rofecoxib-d5
Rofecoxib-d₅ is the deuterium labeled Rofecoxib. Rofecoxib is a potent, specific and orally active COX-2 inhibitor, with IC₅₀s of 26 and 18 nM for human COX-2 in human osteosarcoma cells and Chinese hamster ovary cells, with a 1000-fold selectivity for COX-2 over human COX-1 (IC₅₀ > 50 μM in U937 cells and > 15 μM in Chinese hamster ovary cells) .

HY-105028S

Tenidap-d3
Tenidap-d₃ is the deuterium labeled Tenidap. Tenidap, a non-steroidal anti-inflammatory drug, is a selective COX-1 inhibitor, with IC₅₀ values of 0.03 μM and 1.2 μM for COX-1 and COX-2, respectively. Tenidap has anti-inflammatory and antirheumatic properties . Tenidap is also a specific SLC26A3 inhibitor .

HY-15762S

Valdecoxib-d3
Valdecoxib-d₃ is the deuterium labeled Valdecoxib. Valdecoxib is a highly potent and selective inhibitor of COX-2, with IC₅₀s of 5 nM and 140 μM for COX-2 and COX-1, respeceively. Valdecoxib can be used in the research of arthritis and pain .

HY-W745860

Hexahydrocurcumin-d6
Hexahydrocurcumin-d₆ is the deuterium labeled Hexahydrocurcumin (HY-N0929). Hexahydrocurcumin is one of the major metabolites of curcumin and a selective, orally active COX-2 inhibitor. Hexahydrocurcumin is inactive against COX-1. Hexahydrocurcumin has antioxidant, anticancer and anti-inflammatory activities .

HY-118827S

Vedaprofen-d3
Vedaprofen-d₃ is the deuterium labeled Vedaprofen. Vedaprofen (Quadrisol) is a COX-1 selective nonsteroidal anti-inflammatory agent (NSAID) for serum TxB2 and exudate PGE2 inhibition . Vedaprofen is a Escherichia coli (E. coli) sliding clamp (SC) inhibitor with the IC₅₀ of 222 μM .

HY-B0363S

Nimesulide-d5
Nimesulide-d₅ is a deuterium labeled Nimesulide. Nimesulide is a selective COX-2 inhibitor, with IC₅₀s of 70 nM-70 μM in a time-dependent manner, but it shows no effect on COX-1 (IC₅₀ >100 μM). Nimesulide has potent anti-inflammatory, analgesic and antipyretic properties .

HY-15321S1

Etoricoxib-13C,d3
Etoricoxib- ¹³C,d₃ is the ¹³C- and deuterium labeled Etoricoxib. Etoricoxib (MK-0663) is a non steroidal anti-inflammatory agent, acting as a selective and orally active COX-2 inhibitor, with IC50s of 1.1 μM and 116 μM for COX-2 and COX-1 in human whole blood.

HY-B0363S1

Nimesulide-13C6
Nimesulide- ¹³C₆ (R805- ¹³C₆) is ¹³C labeled Nimesulide. Nimesulide is a selective *COX-2* inhibitor, with IC₅₀s of 70 nM-70 μM in a time-dependent manner, but it shows no effect on COX-1 (IC₅₀ >100 μM). Nimesulide has potent anti-inflammatory, analgesic and antipyretic properties.

HY-B0335S

Tolfenamic acid-d4
Tolfenamic acid-d₄ is the deuterium labeled Tolfenamic Acid. Tolfenamic Acid (GEA 6414) is a non-steroidal anti-inflammatory and anti-cancer agent, selectively inhibits COX-2, with an IC₅₀ of 13.49 μM (3.53 μg/mL) in LPS-treated (COX-2) canine DH82 monocyte/macrophage cells, but shows no effect on COX-1 .

HY-W777079

Valdecoxib-13C2,15N
Valdecoxib- ¹³C₂, ¹⁵N (SC 65872- ¹³C₂, ¹⁵N) is the ¹³C- and ¹⁵N-labeled Valdecoxib (HY-15762). Valdecoxib is a highly potent and selective inhibitor of COX-2, with IC₅₀s of 5 nM and 140 μM for COX-2 and COX-1, respeceively. Valdecoxib can be used in the research of arthritis and pain.

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