162011-90-7
162011-90-7
Chemical Structure
Rofecoxib
Synonym(s): MK 966
- CAS No.: 162011-90-7
- Formula:C17H14O4S
- Molecular Weight:314.36
IUPAC Name: 4-(4-(methylsulfonyl)phenyl)-3-phenylfuran-2(5H)-one
InChIKey: RZJQGNCSTQAWON-UHFFFAOYSA-N
SMILES: O=C1OCC(C2=CC=C(S(=O)(C)=O)C=C2)=C1C3=CC=CC=C3
Biological Activity: Rofecoxib is a potent, specific and orally active COX-2 inhibitor, with IC50s of 26 and 18 nM for human COX-2 in human osteosarcoma cells and Chinese hamster ovary cells, with a 1000-fold selectivity for COX-2 over human COX-1 (IC50 > 50 μM in U937 cells and > 15 μM in Chinese hamster ovary cells).
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Rofecoxib | 99.89% | Rofecoxib is a potent, specific and orally active COX-2 inhibitor, with IC50s of 26 and 18 nM for human COX-2 in human osteosarcoma cells and Chinese hamster ovary cells, with a 1000-fold selectivity for COX-2 over human COX-1 (IC50 > 50 μM in U937 cells and > 15 μM in Chinese hamster ovary cells). | ||||||||||||||||||||
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Rofecoxib (Standard) | ≥98% | Rofecoxib (Standard) is the analytical standard of Rofecoxib. This product is intended for research and analytical applications. Rofecoxib is a potent, specific and orally active COX-2 inhibitor, with IC50s of 26 and 18 nM for human COX-2 in human osteosarcoma cells and Chinese hamster ovary cells, with a 1000-fold selectivity for COX-2 over human COX-1 (IC50 > 50 μM in U937 cells and > 15 μM in Chinese hamster ovary cells). | ||||||||||||||||||||
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Rofecoxib-d5 | Rofecoxib-d5 is the deuterium labeled Rofecoxib. Rofecoxib is a potent, specific and orally active COX-2 inhibitor, with IC50s of 26 and 18 nM for human COX-2 in human osteosarcoma cells and Chinese hamster ovary cells, with a 1000-fold selectivity for COX-2 over human COX-1 (IC50 > 50 μM in U937 cells and > 15 μM in Chinese hamster ovary cells). | |||||||||||||||||||||
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Structural Analogs
-
Similarity Score 0.76
HY-W1629833,4-Diphenyl-5H-furan-2-one -
Similarity Score 0.75
HY-105290DRF-4848 -
Similarity Score 0.71
HY-126453VU0487836 -
Similarity Score 0.69
HY-W2674592,3-Diphenylmaleic anhydride -
Similarity Score 0.68
HY-U00129SC57666 -
Similarity Score 0.65
HY-N15186Gymnoascolide A -
Similarity Score 0.63
HY-118691BMS-347070 -
Similarity Score 0.61
HY-169298Ferroptosis-IN-15 -
Similarity Score 0.61
![2,2,2-Trifluoro-1-(4'-(methylsulfonyl)-[1,1'-biphenyl]-4-yl)ethanone Chemical Structure](//file.medchemexpress.com/product_pic/hy-77024.gif)
HY-770242,2,2-Trifluoro-1-(4'-(methylsulfonyl)-[1,1'-biphenyl]-4-yl)ethanone -
Explore the MedChemAI to find more analogs
![2,2,2-Trifluoro-1-(4'-(methylsulfonyl)-[1,1'-biphenyl]-4-yl)ethanone Chemical Structure](http://file.medchemexpress.com/product_pic/hy-77024.gif)
