847163-28-4
847163-28-4
Chemical Structure
ML351
- CAS 番号: 847163-28-4
- Formula:C15H11N3O
- Molecular Weight:249.27
IUPAC Name: 5-(methylamino)-2-(naphthalen-1-yl)oxazole-4-carbonitrile
InChIKey: DYXYXTDIFMDJIR-UHFFFAOYSA-N
SMILES: N#CC1=C(NC)OC(C2=C3C=CC=CC3=CC=C2)=N1
Biological Activity: ML351 is a potent and highly specific 15-LOX-1 inhibitor with an IC50 of 200 nM. ML351 shows excellent selectivity (>250-fold) versus the related isozymes, 5-LOX, platelet 12-LOX, 15-LOX-2, ovine COX-1, and human COX-2[1]. ML351 prevents dysglycemia and reduces β-cell oxidative stress in nonobese diabetic mouse model of T1D[2].
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ML351 | 99.16% | ML351 is a potent and highly specific 15-LOX-1 inhibitor with an IC50 of 200 nM. ML351 shows excellent selectivity (>250-fold) versus the related isozymes, 5-LOX, platelet 12-LOX, 15-LOX-2, ovine COX-1, and human COX-2. ML351 prevents dysglycemia and reduces β-cell oxidative stress in nonobese diabetic mouse model of T1D. | ||||||||||||||||||||
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References
Keywords
