2 Results for "

COX-2-IN-17

" in MedChemExpress (MCE) Product Catalog:
Products (2)

2 Results for "COX-2-IN-17" in MCE Product Catalog:

Cat. No.: HY-147748
CAS No.: 2411390-10-6
Target:  

COX

Research Areas:  

Inflammation/Immunology

COX-2-IN-17 (compound 10) is a potent and BBB-penetrated COX-2 (cyclooxygenase-2) inhibitor, with an IC50 of 0.02 μM. COX-2-IN-17 shows anti-inflammatory and analgesic activities. COX-2-IN-17 attenuates hyperalgesia in the neurogenic phase as well as the inflammatory phase .
loading...
    loading...
Cat. No.: HY-165394
CAS No.: 129724-42-1
Melafolone is a potent dual COX-2/EGFR inhibitor with IC50s of 13.2 μM (COX-2) and 17.4 μM (EGFR). Melafolone enhances the effect of anti-PD-1 through vascular normalization and PD-L1 downregulation via the PI3K/Akt pathway in Lewis lung carcinoma (LLC) and CMT167 models. Melafolone can be used for lung cancer research .
loading...
    loading...