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Results for "

CaSR agonist

" in MedChemExpress (MCE) Product Catalog:

By Targets:	CaSR (25) 5-HT Receptor (1) Biochemical Assay Reagents (1) Calcium Channel (1) Endogenous Metabolite (1) Interleukin Related (1) Isotope-Labeled Compounds (1) PPAR (1) Reference Standards (3) TNF Receptor (1) Wnt (1) β-catenin (1)
By Research Areas:	Cancer (3) Endocrinology (6) Inflammation/Immunology (1) Metabolic Disease (10) Neurological Disease (7)

Inhibitors & Agonists

Biochemical Assay Reagents

Peptides

Natural
Products

Isotope-Labeled Compounds

Targets Recommended: CaSR

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-139201A

Poly-D-lysine hydrobromide (MW 70000-150000) 1 Publications Verification PDLHB (MW 70000-150000)	Biochemical Assay Reagents CaSR	Neurological Disease Cancer
Poly-D-lysine hydrobromide (MW 70000-150000) is a synthetic polymeric substrate and is one of the most widely used substrate in neural cell culture. Poly-D-lysine hydrobromide is a *CaSR* agonist peptide .

HY-17613

Evocalcet 3 Publications Verification KHK7580	CaSR	Metabolic Disease
Evocalcet (KHK7580) is an orally active calcium sensing receptor (CaSR) agonist. Evocalcet inhibits the secretion of parathyroid hormone (PTH) from parathyroid gland cells. Evocalcet can be used for the research of hyperparathyroidism .

HY-139201

Poly-D-lysine hydrobromide (MW 30000-70000) PDLHB (MW 30000-70000)	CaSR	Neurological Disease Metabolic Disease Cancer
Poly-D-lysine hydrobromide (MW 30000-70000) is a synthetic polymeric substrate and is one of the most widely used substrate in neural cell culture. Poly-D-lysine hydrobromide is a *CaSR* agonist peptide .

HY-139201B

Poly-D-lysine hydrobromide (MW 84000) PDLHB (MW 84000)	CaSR	Neurological Disease Cancer
Poly-D-lysine hydrobromide (MW 84000) is a synthetic polymeric substrate and is one of the most widely used substrate in neural cell culture. Poly-D-lysine hydrobromide is a *CaSR* agonist peptide .

HY-P4376A

Gamma-Glu-Abu TFA	CaSR	Neurological Disease
Gamma-Glu-Abu TFA is the TFA salt form of Gamma-Glu-Abu (HY-P4376). Gamma-Glu-Abu TFA is an agonist for calcium sensing receptor (CaSR), that activates the *CaSR* with an EC₅₀ of 0.21 μM in HEK-293 cell .

HY-139201D

Poly-D-lysine hydrobromide (MW 4000-15000) PDLHB (MW 4000-15000)	CaSR	Others
Poly-D-lysine hydrobromide (MW 4000-15000) (PDLHB (MW 4000-15000)) is an artificially synthesized polymer matrix widely used in neuronal cell culture. Poly-D-lysine hydrobromide is also known as a calcium-sensing receptor (CaSR) agonist peptide .

HY-12557

γ-Glutamylvaline γ-Glu-Val	Endogenous Metabolite CaSR Wnt TNF Receptor Interleukin Related PPAR β-catenin	Inflammation/Immunology
γ‑Glutamylvaline (γ-Glu-Val) is a calcium‑sensing receptor (CaSR) agonist. γ‑Glutamylvaline activates CaSR and facilitates its binding to β‑arrestin 2 to modulate inflammatory and metabolic homeostasis signaling. γ‑Glutamylvaline inhibits TNF‑α‑induced IL‑6/MCP‑1 and enhances adiponectin/PPARγ in adipocytes. γ‑Glutamylvaline upregulates Wnt5a, restores β‑catenin phosphorylation, and reduces serine‑phosphorylated IRS‑1 in adipocytes. γ-Glutamylvaline can be used for the research of low-grade chronic inflammation .

HY-109106A

Upacicalcet sodium SK-1403; AJT240; PLS240	CaSR	Endocrinology
Upacicalcet sodium is a non-peptide calcimimetic that acts as a *CaSR* agonist (EC₅₀ = 10.8 nM). Upacicalcet sodium reduces serum intact parathyroid hormone (iPTH) and serum Ca ²⁺ levels, reducing hypocalcemia and gastrointestinal complications. Upacicalcet sodium sodium improves vascular calcification and bone disorders in the Adenine (HY-B0152)-induced secondary hyperparathyroidism (SHPT) rat model. Upacicalcet sodium sodium inhibits cortical pore formation and reduces bone fibrosis in rats with chronic kidney disease (CKD). Upacicalcet sodium is useful for studying SHPT .

HY-P11200

γ-Glu-Asn γ-Glutamylasparagine	Calcium Channel	Neurological Disease
γ-Glu-Asn (γ-Glutamylasparagine) is a calcium sensing receptor (CaSR) agonist. γ-Glu-Asn is a dipeptide composed of glutamic acid and asparagine .

HY-121584

Lycoperodine-1 1 Publications Verification Cyclomethyltryptophan	CaSR	Metabolic Disease
Lycoperodine-1 (Cyclomethyltryptophan) is an active product that can be isolated from tomato fruits (Lycopersicon sculentum). Lycoperodine-1 act as an agonist of Ca ²⁺ sensing receptors (CaSR) .

HY-W843885

H-Glu-Thr-OH L-α-Glutamyl-L-threonine; Glu-Thr	CaSR	Others
H-Glu-Thr-OH (L-α-Glutamyl-L-threonine) is a dipeptide made up of two amino acids—glutamic acid (Glu) and threonine (Thr)—connected by a peptide bond, and it acts as an agonist for the extracellular calcium-sensing receptor (CaSR) .

HY-139201H

Poly-D-lysine hydrobromide (MW ≥300000) PDLHB (MW ≥300000)	CaSR	Others
Poly-D-lysine hydrobromide (MW ≥300000) (PDLHB (MW ≥300000)) is a cationic polymer and cell adhesion promoter. Poly-D-lysine hydrobromide (MW ≥300000) serves as a substrate coating to support the adhesion and proliferation of rat dorsal root ganglion satellite glial cells in vitro. Poly-D-lysine hydrobromide (MW ≥300000) promotes the adhesion and immobilization of cells on plastic culture dishes. Poly-D-lysine hydrobromide is also known as a calcium-sensing receptor (CaSR) agonist peptide .

HY-139201C

Poly-D-lysine hydrobromide (MW 1000-5000) PDLHB (MW 1000-5000)	CaSR	Others
Poly-D-lysine hydrobromide (MW 1000-5000) (PDLHB (MW 1000-5000)) is a synthetic cationic polypeptide polymer commonly used as a cell adhesion promoter and surface coating molecule. Poly-D-lysine hydrobromide is also known as a calcium-sensing receptor (CaSR) agonist peptide .

HY-139201E

Poly-D-lysine hydrobromide (MW 150000-300000) PDLHB (MW 150000-300000)	CaSR 5-HT Receptor	Metabolic Disease
Poly-D-lysine hydrobromide (MW 150000-300000) is a synthetic polymer composed of D-lysine residues and is one of the most widely used matrices in neural cell culture applications. Poly-D-lysine hydrobromide (MW 150000-300000) can be used as a non-specific cell adhesion enhancer. Poly-D-lysine hydrobromide (MW 30000-70000) is an orally active *CaSR* agonist peptide that indirectly activates the 5-HT₃ receptor signaling pathway, delaying gastric emptying and thereby slowing the rate at which glucose enters the small intestine and is absorbed .

HY-17613R

Evocalcet (Standard) KHK7580 (Standard)	Reference Standards CaSR	Metabolic Disease
Evocalcet (Standard) is the analytical standard of Evocalcet. This product is intended for research and analytical applications. Evocalcet (KHK7580) is an orally active calcium sensing receptor (CaSR) agonist. Evocalcet inhibits the secretion of parathyroid hormone (PTH) from parathyroid gland cells. Evocalcet can be used for the research of hyperparathyroidism .

HY-117851

AC-265347	CaSR	Metabolic Disease Endocrinology
AC-265347 is a calcium-sensing receptor (CaSR) agonist and positive allosteric modulator (ago-PAM) with the functional affinity (pK_B) of 5.1. AC-265347 can be used for the research of hyperparathyroidism and related diseases .

HY-179475

KP-2067	CaSR	Endocrinology
KP-2067 is a form of the *CaSR* agonist peptide. KP-2067 can result in dose-dependent activation of CaSR in HEK293T overexpressing hCaSR cell line, with an EC₅₀ of 18.4 μM. KP-2067 significantly reduces plasma parathyroid hormone in rat model .

HY-P4376

Gamma-Glu-Abu	CaSR	Neurological Disease
Gamma-Glu-Abu is an agonist for calcium sensing receptor (CaSR), that activates the *CaSR* with an EC₅₀ of 0.21 μM in HEK-293 cell .

HY-109106

Upacicalcet SK-1403 free acid; AJT240 free acid; PLS240 free acid	CaSR	Endocrinology
Upacicalcet is a non-peptide calcimimetic that acts as a *CaSR* agonist (EC₅₀ = 10.8 nM). Upacicalcet reduces serum intact parathyroid hormone (iPTH) and serum Ca2+ levels, reducing hypocalcemia and gastrointestinal complications. Upacicalcet improves vascular calcification and bone disorders in the Adenine (HY-B0152)-induced secondary hyperparathyroidism (SHPT) rat model. Upacicalcet inhibits cortical pore formation and reduces bone fibrosis in rats with chronic kidney disease (CKD). Upacicalcet is useful for studying SHPT .

HY-P11832

CaSR agonist peptide-1	CaSR	Endocrinology
CaSR agonist peptide-1 is a human calcium-sensing receptor (CaSR) agonist. CaSR agonist peptide-1 activates CaSR by binding to it. CaSR agonist peptide-1 can be used in studies related to secondary hyperparathyroidism .

HY-107773

GSK3004774	CaSR	Metabolic Disease
GSK3004774 is a potent, nonabsorbable agonist of *CaSR, with an pEC₅₀* of 7.3, 6.6 and 6.5 for human, mouse and rat CaSR, respectively. GSK3004774 shows an EC₅₀ of 50 nM for human CaSR .

HY-P11668

Gosicalcetide	CaSR	Neurological Disease
Gosicalcetide is a calcium sensing receptor (CaSR) agonist .

HY-121584R

Lycoperodine-1 (Standard) Cyclomethyltryptophan (Standard)	CaSR Reference Standards	Metabolic Disease
Lycoperodine-1 (Standard) is the analytical standard of Lycoperodine-1. This product is intended for research and analytical applications. Lycoperodine-1 (Cyclomethyltryptophan) is an active product that can be isolated from tomato fruits (Lycopersicon sculentum). Lycoperodine-1 act as an agonist of Ca2+ sensing receptors (CaSR) .

HY-17613S

Evocalcet-d4 KHK7580-d₄	Isotope-Labeled Compounds CaSR	Metabolic Disease
Evocalcet-d₄ (KHK7580-d₄) is deuterium labeled Evocalcet. Evocalcet (KHK7580) is an orally active calcium sensing receptor (CaSR) agonist. Evocalcet inhibits the secretion of parathyroid hormone (PTH) from parathyroid gland cells. Evocalcet can be used for the research of hyperparathyroidism .

HY-109106B

(Rac)-Upacicalcet (Rac)-SK-1403 free acid; (Rac)-AJT240 free acid; (Rac)-PLS240 free acid	CaSR	Endocrinology
(Rac)-Upacicalcet is the racemate of Upacicalcet (HY-109106). Upacicalcet is a non-peptide calcimimetic that acts as a *CaSR* agonist (EC₅₀ = 10.8 nM). Upacicalcet reduces serum intact parathyroid hormone (iPTH) and serum Ca2+ levels, reducing hypocalcemia and gastrointestinal complications. Upacicalcet improves vascular calcification and bone disorders in the Adenine (HY-B0152)-induced secondary hyperparathyroidism (SHPT) rat model. Upacicalcet inhibits cortical pore formation and reduces bone fibrosis in rats with chronic kidney disease (CKD). Upacicalcet is useful for studying SHPT .

HY-107773R

GSK3004774 (Standard)	Reference Standards CaSR	Metabolic Disease
GSK3004774 (Standard) is the analytical standard of GSK3004774 (HY-107773). This product is intended for research and analytical applications. GSK3004774 is a potent, nonabsorbable agonist of CaSR, with an pEC₅₀ of 7.3, 6.6 and 6.5 for human, mouse and rat CaSR, respectively. GSK3004774 shows an EC₅₀ of 50 nM for human CaSR .

Cat. No.	Product Name	Type

HY-139201D

Poly-D-lysine hydrobromide (MW 4000-15000) PDLHB (MW 4000-15000)	Biochemical Assay Reagents
Poly-D-lysine hydrobromide (MW 4000-15000) (PDLHB (MW 4000-15000)) is an artificially synthesized polymer matrix widely used in neuronal cell culture. Poly-D-lysine hydrobromide is also known as a calcium-sensing receptor (CaSR) agonist peptide .

HY-139201H

Poly-D-lysine hydrobromide (MW ≥300000) PDLHB (MW ≥300000)	Biochemical Assay Reagents
Poly-D-lysine hydrobromide (MW ≥300000) (PDLHB (MW ≥300000)) is a cationic polymer and cell adhesion promoter. Poly-D-lysine hydrobromide (MW ≥300000) serves as a substrate coating to support the adhesion and proliferation of rat dorsal root ganglion satellite glial cells in vitro. Poly-D-lysine hydrobromide (MW ≥300000) promotes the adhesion and immobilization of cells on plastic culture dishes. Poly-D-lysine hydrobromide is also known as a calcium-sensing receptor (CaSR) agonist peptide .

Poly-D-lysine hydrobromide (MW ≥300000)

PDLHB (MW ≥300000)

Biochemical Assay Reagents

Poly-D-lysine hydrobromide (MW ≥300000) (PDLHB (MW ≥300000)) is a cationic polymer and cell adhesion promoter. Poly-D-lysine hydrobromide (MW ≥300000) serves as a substrate coating to support the adhesion and proliferation of rat dorsal root ganglion satellite glial cells in vitro. Poly-D-lysine hydrobromide (MW ≥300000) promotes the adhesion and immobilization of cells on plastic culture dishes. Poly-D-lysine hydrobromide is also known as a calcium-sensing receptor (CaSR) agonist peptide .

HY-139201C

Poly-D-lysine hydrobromide (MW 1000-5000) PDLHB (MW 1000-5000)	Biochemical Assay Reagents
Poly-D-lysine hydrobromide (MW 1000-5000) (PDLHB (MW 1000-5000)) is a synthetic cationic polypeptide polymer commonly used as a cell adhesion promoter and surface coating molecule. Poly-D-lysine hydrobromide is also known as a calcium-sensing receptor (CaSR) agonist peptide .

HY-139201E

Poly-D-lysine hydrobromide (MW 150000-300000) PDLHB (MW 150000-300000)	Biochemical Assay Reagents
Poly-D-lysine hydrobromide (MW 150000-300000) is a synthetic polymer composed of D-lysine residues and is one of the most widely used matrices in neural cell culture applications. Poly-D-lysine hydrobromide (MW 150000-300000) can be used as a non-specific cell adhesion enhancer. Poly-D-lysine hydrobromide (MW 30000-70000) is an orally active *CaSR* agonist peptide that indirectly activates the 5-HT₃ receptor signaling pathway, delaying gastric emptying and thereby slowing the rate at which glucose enters the small intestine and is absorbed .

Poly-D-lysine hydrobromide (MW 150000-300000)

PDLHB (MW 150000-300000)

Biochemical Assay Reagents

Poly-D-lysine hydrobromide (MW 150000-300000) is a synthetic polymer composed of D-lysine residues and is one of the most widely used matrices in neural cell culture applications. Poly-D-lysine hydrobromide (MW 150000-300000) can be used as a non-specific cell adhesion enhancer. Poly-D-lysine hydrobromide (MW 30000-70000) is an orally active CaSR agonist peptide that indirectly activates the 5-HT₃ receptor signaling pathway, delaying gastric emptying and thereby slowing the rate at which glucose enters the small intestine and is absorbed .

Cat. No.	Product Name	Target	Research Area

HY-P4376A

Gamma-Glu-Abu TFA	CaSR	Neurological Disease
Gamma-Glu-Abu TFA is the TFA salt form of Gamma-Glu-Abu (HY-P4376). Gamma-Glu-Abu TFA is an agonist for calcium sensing receptor (CaSR), that activates the *CaSR* with an EC₅₀ of 0.21 μM in HEK-293 cell .

HY-12557

γ-Glutamylvaline γ-Glu-Val	Endogenous Metabolite CaSR Wnt TNF Receptor Interleukin Related PPAR β-catenin	Inflammation/Immunology
γ‑Glutamylvaline (γ-Glu-Val) is a calcium‑sensing receptor (CaSR) agonist. γ‑Glutamylvaline activates CaSR and facilitates its binding to β‑arrestin 2 to modulate inflammatory and metabolic homeostasis signaling. γ‑Glutamylvaline inhibits TNF‑α‑induced IL‑6/MCP‑1 and enhances adiponectin/PPARγ in adipocytes. γ‑Glutamylvaline upregulates Wnt5a, restores β‑catenin phosphorylation, and reduces serine‑phosphorylated IRS‑1 in adipocytes. γ-Glutamylvaline can be used for the research of low-grade chronic inflammation .

HY-P11200

γ-Glu-Asn γ-Glutamylasparagine	Calcium Channel	Neurological Disease
γ-Glu-Asn (γ-Glutamylasparagine) is a calcium sensing receptor (CaSR) agonist. γ-Glu-Asn is a dipeptide composed of glutamic acid and asparagine .

HY-W843885

H-Glu-Thr-OH L-α-Glutamyl-L-threonine; Glu-Thr	CaSR	Others
H-Glu-Thr-OH (L-α-Glutamyl-L-threonine) is a dipeptide made up of two amino acids—glutamic acid (Glu) and threonine (Thr)—connected by a peptide bond, and it acts as an agonist for the extracellular calcium-sensing receptor (CaSR) .

HY-179475

KP-2067	CaSR	Endocrinology
KP-2067 is a form of the *CaSR* agonist peptide. KP-2067 can result in dose-dependent activation of CaSR in HEK293T overexpressing hCaSR cell line, with an EC₅₀ of 18.4 μM. KP-2067 significantly reduces plasma parathyroid hormone in rat model .

HY-P4376

Gamma-Glu-Abu	CaSR	Neurological Disease
Gamma-Glu-Abu is an agonist for calcium sensing receptor (CaSR), that activates the *CaSR* with an EC₅₀ of 0.21 μM in HEK-293 cell .

HY-P11832

CaSR agonist peptide-1	CaSR	Endocrinology
CaSR agonist peptide-1 is a human calcium-sensing receptor (CaSR) agonist. CaSR agonist peptide-1 activates CaSR by binding to it. CaSR agonist peptide-1 can be used in studies related to secondary hyperparathyroidism .

HY-P11668

Gosicalcetide	CaSR	Neurological Disease
Gosicalcetide is a calcium sensing receptor (CaSR) agonist .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-121584

Lycoperodine-1 1 Publications Verification Cyclomethyltryptophan	Alkaloids Solanum lycopersicum L. Solanaceae Plants Indole Alkaloids Source Classification	CaSR
Lycoperodine-1 (Cyclomethyltryptophan) is an active product that can be isolated from tomato fruits (Lycopersicon sculentum). Lycoperodine-1 act as an agonist of Ca ²⁺ sensing receptors (CaSR) .

HY-121584R

Lycoperodine-1 (Standard) Cyclomethyltryptophan (Standard)	Structural Classification Alkaloids Solanum lycopersicum L. Solanaceae Plants Indole Alkaloids Source Classification	CaSR Reference Standards
Lycoperodine-1 (Standard) is the analytical standard of Lycoperodine-1. This product is intended for research and analytical applications. Lycoperodine-1 (Cyclomethyltryptophan) is an active product that can be isolated from tomato fruits (Lycopersicon sculentum). Lycoperodine-1 act as an agonist of Ca2+ sensing receptors (CaSR) .

Cat. No.	Product Name	Chemical Structure

HY-17613S

Evocalcet-d4
Evocalcet-d₄ (KHK7580-d₄) is deuterium labeled Evocalcet. Evocalcet (KHK7580) is an orally active calcium sensing receptor (CaSR) agonist. Evocalcet inhibits the secretion of parathyroid hormone (PTH) from parathyroid gland cells. Evocalcet can be used for the research of hyperparathyroidism .

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CaSR agonist

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