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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
3 Results for "
Calcein acetoxymethyl ester
" in MedChemExpress (MCE) Product Catalog:
Products (3)
3 Results for "Calcein acetoxymethyl ester" in MCE Product Catalog:
90
1
1 Cited Publications
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Calcein Blue AM is a cell staining agent. Calcein Blue AM serves as a substrate for intracellular esterases, which hydrolyze its acetoxymethyl (AM) ester group to convert the non-fluorescent reagent into fluorescent Calcein Blue. Calcein Blue AM passively penetrates the plasma membrane of both live and dead cells; it is converted into a polar fluorescent product and retained in the cytoplasm of live cells, whereas dead cells cannot retain the dye. Calcein Blue AM exhibits significant dye leakage, and its fluorescence intensity gradually decreases over time. Calcein Blue AM can be used for endpoint-based cell viability assays and short-term cell tracking experiments with a duration of no more than 4 hours.
Cat. No.: HY-176287
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ARN25657 is a dual-acting D3R/GSK-3β modulator. ARN25657 has both partial D3R agonist activity (EC50 = 15.2 nM, Ki =1.5 nM) and potent GSK-3β inhibitor activity (IC50 = 19.3 nM). ARN25657 exhibits excellent GSK-3β selectivity over FYN, PKA, and CDK5/p35. ARN25657 inhibits P-glycoprotein (P-gP)-mediated acetoxymethyl calcein efflux and improves in vitro ADME properties while maintaining a balanced dual-target profile. ARN25657 is useful for studying bipolar disorder and related neuropsychiatric disorders .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
