Scientific Reviews
Product Guides
Blogs
Topics
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
10 Results for "
Carfilzomib
" in MedChemExpress (MCE) Product Catalog:
Products (10)
10 Results for "Carfilzomib" in MCE Product Catalog:
77
77 Publications Verification
Synonyms: PR-171
Target:
Research Areas:
Carfilzomib (PR-171) is an irreversible proteasome inhibitor with an IC50 of 5 nM in ANBL-6 and RPMI 8226 cells.
3
3 Cited Publications
Target:
Research Areas:
WRR139 is a peptide vinyl sulfone involving in disease processes such as inflammation and cancer. WRR139 is also a cytosolic enzyme N-glycanase 1 (NGLY1) and Nrf1 inhibitor. WRR139 enhances Carfilzomib cytotoxicity against cancer cells .
1
Target:
Research Areas:
Cat. No.: HY-159127
CAS No.: 2836263-09-1
HRS-4642 is a high affinity, selective, long-acting, and non-covalent KRAS G12D inhibitor with a Kd value of 0.083 nM. HRS-4642 inhibits the binding of KRAS G12D to SOS1 or RAF1, thereby blocking the downstream MEK-ERK signaling pathway. HRS-4642 promotes Apoptosis. HRS-4642 alone or combined with Carfilzomib (HY-10455) effectively shapes the tumor microenvironment. HRS-4642 has an anti-cancer effect on pancreatic and colorectal cancers carrying the KRAS G12D mutation .
Cat. No.: HY-10455R
CAS No.: 868540-17-4
Synonyms: PR-171 (Standard)
Research Areas:
Carfilzomib (Standard) is the analytical standard of Carfilzomib. This product is intended for research and analytical applications. Carfilzomib (PR-171) is an irreversible proteasome inhibitor with an IC50 of 5 nM in ANBL-6 and RPMI 8226 cells.
Cat. No.: HY-I0510
CAS No.: 868540-16-3
Target:
Research Areas:
Carfilzomib intermediate-1 (Intermediate IV) is a key intermediate for Carfilzomib (HY-10455) synthesis .
Target:
Research Areas:
MC-Val-Cit-PAB-carfilzomib iodide is a conjugate of the ADC toxin molecule and the linker. MC-Val-Cit-PAB-carfilzomib iodide is formed by connecting the irreversible proteasome inhibitor Carfilzomib (HY-10455) and the ADC linker MC-Val-Cit-PAB (HY-78738).
Cat. No.: HY-Z0028
CAS No.: 1541172-75-1
Synonyms: Carfilzomib Impurity 2
Target:
Research Areas:
(S)-N-((S)-1-(((2R,4S)-1,2-Dihydroxy-2,6-dimethyl-3-oxoheptan-4-yl)amino)-1-oxo-3-phenylpropan-2-yl)-4-methyl-2-((S)-2-(2-morpholinoacetamido)-4-phenylbutanamido)pentanamide is a drug intermediate for synthesis of various active compounds.
Cat. No.: HY-P11311
CAS No.: 1356828-46-0
Target:
Research Areas:
-
-
Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
