MC-Val-Cit-PAB-carfilzomib iodide

Name: MC-Val-Cit-PAB-carfilzomib iodide
Brand: MedChemExpress
SKU: HY-128903
Rating: 4.5 (1 reviews)

Cat. No.: HY-128903 Purity: 95.22%: Data Sheet
COA

SDS
Handling Instructions
FAQs
Technical Support

MC-Val-Cit-PAB-carfilzomib iodide is a agent-linker conjugate for ADC with potent antitumor activity by using carfilzomib (an irreversible proteasome inhibitor), linked via the ADC linker MC-Val-Cit-PAB.

연구목적의 판매만을 진행합니다. 환자를 대상으로 한 판매는 하지 않습니다.

MC-Val-Cit-PAB-carfilzomib iodide 화학구조

CAS No. : 2055896-83-6

사이즈	재고	수량
1 mg	해외재고보유	Estimated Time of Arrival: December 31
5 mg	견적 받기
10 mg	견적 받기

or 대량구매 문의

* 장바구니에 담기 전 물품의 수량을 선택해 주십시오.

This product is a controlled substance and not for sale in your territory.

고객리뷰

Based on 1 publication(s) in Google Scholar

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Biological Activity
순도&문서
References
고객리뷰

제품 설명

IC₅₀ & Target

Traditional Cytotoxic Agents

In Vitro

Antibody-drug conjugates (ADCs) carry a highly potent small-molecule toxin covalently connected on the antibody via a proper linker. For therapeutic ADCs in cancer treatment, the antibody targets specific antigen of tumor cell surface with high binding affinity, thereafter the intact ADC was internalized into the tumor cells with the antigen and digested in the lysosome to release the antitumor toxin^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

분자량

1402.46

화학식

C₆₈H₉₆IN₁₁O₁₃

CAS No.

2055896-83-6

Appearance

Solid

Color

White to off-white

SMILES

O=C([C@]1(CO1)C)[C@H](CC(C)C)NC([C@H](CC2=CC=CC=C2)NC([C@H](CC(C)C)NC([C@H](CCC3=CC=CC=C3)NC(C[N+]4(CCOCC4)CC5=CC=C(NC([C@H](CCCNC(N)=O)NC([C@H](C(C)C)NC(CCCCCN6C(C=CC6=O)=O)=O)=O)=O)C=C5)=O)=O)=O)=O.[I-]

선적

Room temperature in continental US; may vary elsewhere.

보관

-20°C, protect from light, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)

용액&용해도

In Vitro:

DMSO : 230 mg/mL (164.00 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	0.7130 mL	3.5652 mL	7.1303 mL
5 mM	0.1426 mL	0.7130 mL	1.4261 mL
10 mM	0.0713 mL	0.3565 mL	0.7130 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

몰농도 계산기
농도 희석 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

순도&문서

Purity: 95.22%

Select Batch:

Data Sheet (272 KB) SDS (252 KB)

COA (250 KB) HNMR (553 KB) LCMS (104 KB)

Handling Instructions (2659 KB)

References

[1]. Staben LR, et al. Targeted drug delivery through the traceless release of tertiary and heteroaryl amines from antibody-drug conjugates. Nat Chem. 2016 Dec;8(12):1112-1119. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	0.7130 mL	3.5652 mL	7.1303 mL	17.8258 mL
	5 mM	0.1426 mL	0.7130 mL	1.4261 mL	3.5652 mL
	10 mM	0.0713 mL	0.3565 mL	0.7130 mL	1.7826 mL
	15 mM	0.0475 mL	0.2377 mL	0.4754 mL	1.1884 mL
	20 mM	0.0357 mL	0.1783 mL	0.3565 mL	0.8913 mL
	25 mM	0.0285 mL	0.1426 mL	0.2852 mL	0.7130 mL
	30 mM	0.0238 mL	0.1188 mL	0.2377 mL	0.5942 mL
	40 mM	0.0178 mL	0.0891 mL	0.1783 mL	0.4456 mL
	50 mM	0.0143 mL	0.0713 mL	0.1426 mL	0.3565 mL
	60 mM	0.0119 mL	0.0594 mL	0.1188 mL	0.2971 mL
	80 mM	0.0089 mL	0.0446 mL	0.0891 mL	0.2228 mL
	100 mM	0.0071 mL	0.0357 mL	0.0713 mL	0.1783 mL