2. Antibody-drug Conjugate/ADC Related
  3. Drug-Linker Conjugates for ADC
  4. MC-Val-Cit-PAB-carfilzomib iodide

MC-Val-Cit-PAB-carfilzomib iodide 

Cat. No.: HY-128903 Purity: 96.58%
COA Handling Instructions

MC-Val-Cit-PAB-carfilzomib iodide is a agent-linker conjugate for ADC with potent antitumor activity by using carfilzomib (an irreversible proteasome inhibitor), linked via the ADC linker MC-Val-Cit-PAB.

For research use only. We do not sell to patients.

MC-Val-Cit-PAB-carfilzomib iodide Chemical Structure

MC-Val-Cit-PAB-carfilzomib iodide Chemical Structure

CAS No. : 2055896-83-6

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1 mg USD 850 In-stock
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Based on 1 publication(s) in Google Scholar

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Description

MC-Val-Cit-PAB-carfilzomib iodide is a agent-linker conjugate for ADC with potent antitumor activity by using carfilzomib (an irreversible proteasome inhibitor), linked via the ADC linker MC-Val-Cit-PAB.

IC50 & Target

Traditional Cytotoxic Agents

 

Molecular Weight

1402.46

Appearance

Solid

Formula

C68H96IN11O13
CAS No.
SMILES

O=C([[email protected]]1(CO1)C)[[email protected]](CC(C)C)NC([[email protected]](CC2=CC=CC=C2)NC([[email protected]](CC(C)C)NC([[email protected]](CCC3=CC=CC=C3)NC(C[N+]4(CCOCC4)CC5=CC=C(NC([[email protected]](CCCNC(N)=O)NC([[email protected]](C(C)C)NC(CCCCCN6C(C=CC6=O)=O)=O)=O)=O)C=C5)=O)=O)=O)=O.[I-]
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

-20°C, protect from light, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)
Solvent & Solubility
In Vitro: 

DMSO : 230 mg/mL (164.00 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 0.7130 mL 3.5652 mL 7.1303 mL
5 mM 0.1426 mL 0.7130 mL 1.4261 mL
10 mM 0.0713 mL 0.3565 mL 0.7130 mL
*Please refer to the solubility information to select the appropriate solvent.
Purity & Documentation
References
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Keywords:

MC-Val-Cit-PAB-carfilzomib2055896-83-6Drug-Linker Conjugates for ADCInhibitorinhibitorinhibit

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MC-Val-Cit-PAB-carfilzomib iodide
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