MC-Val-Cit-PAB-carfilzomib iodide
Based on 1 Customer Validation
MC-Val-Cit-PAB-carfilzomib iodide is a conjugate of the ADC toxin molecule and the linker. MC-Val-Cit-PAB-carfilzomib iodide is formed by connecting the irreversible proteasome inhibitor Carfilzomib (HY-10455) and the ADC linker MC-Val-Cit-PAB (HY-78738).
For research use only. We do not sell to patients.
- Purity: 95.22%
- CAS No.: 2055896-83-6
- Formula: C68H96IN11O13
- Molecular Weight:1402.46
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Storage:
-20°C, sealed storage, away from moisture and light, under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light, under nitrogen)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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Biological Activity
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Traditional Cytotoxic Agents |
Carfilzomib irreversibly inhibits the activity of the 20S proteasome, leading to the accumulation of misfolded proteins, activating the unfolded protein response (UPR) and ultimately inducing cell apoptosis.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 2055896-83-6
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Appearance Solid
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Molecular Weight 1402.46
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Formula C68H96IN11O13
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Color White to off-white
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SMILES
O=C([C@]1(CO1)C)[C@H](CC(C)C)NC([C@H](CC2=CC=CC=C2)NC([C@H](CC(C)C)NC([C@H](CCC3=CC=CC=C3)NC(C[N+]4(CCOCC4)CC5=CC=C(NC([C@H](CCCNC(N)=O)NC([C@H](C(C)C)NC(CCCCCN6C(C=CC6=O)=O)=O)=O)=O)C=C5)=O)=O)=O)=O.[I-]
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
-20°C, sealed storage, away from moisture and light, under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light, under nitrogen)
Solvent & Solubility
DMSO : 230 mg/mL (164.00 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light, under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light, under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (271 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light, under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 0.7130 mL | 3.5652 mL | 7.1303 mL | 17.8258 mL |
| 5 mM | 0.1426 mL | 0.7130 mL | 1.4261 mL | 3.5652 mL | |
| 10 mM | 0.0713 mL | 0.3565 mL | 0.7130 mL | 1.7826 mL | |
| 15 mM | 0.0475 mL | 0.2377 mL | 0.4754 mL | 1.1884 mL | |
| 20 mM | 0.0357 mL | 0.1783 mL | 0.3565 mL | 0.8913 mL | |
| 25 mM | 0.0285 mL | 0.1426 mL | 0.2852 mL | 0.7130 mL | |
| 30 mM | 0.0238 mL | 0.1188 mL | 0.2377 mL | 0.5942 mL | |
| 40 mM | 0.0178 mL | 0.0891 mL | 0.1783 mL | 0.4456 mL | |
| 50 mM | 0.0143 mL | 0.0713 mL | 0.1426 mL | 0.3565 mL | |
| 60 mM | 0.0119 mL | 0.0594 mL | 0.1188 mL | 0.2971 mL | |
| 80 mM | 0.0089 mL | 0.0446 mL | 0.0891 mL | 0.2228 mL | |
| 100 mM | 0.0071 mL | 0.0357 mL | 0.0713 mL | 0.1783 mL |
MC-Val-Cit-PAB-carfilzomib iodide Related Classifications
HY-128903 Related Classifications
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