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Clozapine

" in MedChemExpress (MCE) Product Catalog:

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製品番号 製品名 Target 研究分野 構造式
  • HY-17366
    Clozapine N-oxide
    Maximum Cited Publications
    145 Publications Verification

    		 Drug Metabolite mAChR Dopamine Receptor Neurological Disease
    Clozapine N-oxide is a major metabolite of Clozapine and a human muscarinic designer receptors (DREADDs) agonist. Clozapine N-oxide activates the DREADD receptor hM3Dq and hM4Di. Clozapine N-oxide can't cross the blood-brain barrier . Clozapine is a potent dopamine antagonist and also a potent and selective muscarinic M4 receptor (EC50=11 nM) agonist .
    Clozapine N-oxide
  • HY-17366A
    Clozapine N-oxide dihydrochloride
    Maximum Cited Publications
    145 Publications Verification

    		 mAChR Dopamine Receptor Drug Metabolite Neurological Disease
    Clozapine N-oxide dihydrochloride is a major metabolite of Clozapine and a human muscarinic designer receptors (DREADDs) agonist. Clozapine N-oxide dihydrochloride activates the DREADD receptor hM3Dq and hM4Di. Clozapine N-oxide dihydrochloride cannot cross the blood-brain barrier . Clozapine is a potent dopamine antagonist and also a potent and selective muscarinic M4 receptor (EC50=11 nM) agonist .
    Clozapine N-oxide dihydrochloride
  • HY-42110
    Deschloroclozapine
    80+ Cited Publications

    		 mAChR Neurological Disease
    Deschloroclozapine, a metabolite of Clozapine, is a highly potent muscarinic DREADDs agonist, with blood-brain barrier permeability. Deschloroclozapine binds to DREADD receptor subtypes hM3Dq and hM4Di with Ki of 6.3 and 4.2 nM, respectively. [ 11C]-Deschloroclozapine is developed as a promising PET tracer for DREADD imaging .
    Deschloroclozapine
  • HY-14539
    Clozapine
    10+ Cited Publications

    HF 1854; ZINC000019796155

    		 Dopamine Receptor mAChR Adrenergic Receptor 5-HT Receptor Ligands for E3 Ligase Neurological Disease Cancer
    Clozapine (HF 1854) is an antipsychotic used for the research of schizophrenia. Clozapine has high affinity for a number of neuroreceptors. Clozapine is a potent antagonist of dopamine D2 with a Ki of 75 nM. Clozapine inhibits the muscarinic M1 receptor and serotonin 5HT2A receptor with Kis of 9.5 nM and 4 nM, respectively . Clozapine is also a potent and selective agonist at the muscarinic M4 receptor (EC50=11 nM) .
    Clozapine
  • HY-42110A
    Deschloroclozapine dihydrochloride
    80+ Cited Publications

    		 mAChR Neurological Disease
    Deschloroclozapine dihydrochloride, a metabolite of Clozapine, is a highly potent muscarinic DREADDs agonist. Deschloroclozapine binds to DREADD receptor subtypes hM3Dq and hM4Di with Ki of 6.3 and 4.2 nM, respectively. [ 11C]-Deschloroclozapine is developed as a promising PET tracer for DREADD imaging .
    Deschloroclozapine dihydrochloride
  • HY-G0021
    N-Desmethylclozapine

    NorClozapine; DesmethylClozapine; NormethylClozapine

    		 mAChR Opioid Receptor Drug Metabolite Virus Protease Infection
    N-Desmethylclozapine is a major active metabolite of the atypical antipsychotic agent Clozapine. N-Desmethylclozapine is a potent, allosteric and partial M1 receptors agonist (EC50=115 nM) and is able to potentiate hippocampal N-methyl-d-aspartate (NMDA) receptor currents through M1 receptor activation. N-Desmethylclozapine is also a δ-opioid agonist .
    N-Desmethylclozapine
  • HY-131881
    JHU37160
    2 Publications Verification

    		 mAChR Neurological Disease
    JHU37160 is a potent and brain-penetrant DREADD agonist, with EC50s of 18.5 nM and 0.2 nM for hM3Dq and hM4Di DREADDs in HEK-293 cells, respectively. JHU37160 exhibits selective [ 3H]Clozapine displacement from DREADDs and not from other Clozapine-binding sites in mice brain tissue .
    JHU37160
  • HY-14539S2
    Clozapine-d4

    HF 1854-d4

    		 Isotope-Labeled Compounds Dopamine Receptor mAChR Adrenergic Receptor 5-HT Receptor Neurological Disease
    Clozapine-d4 is the deuterium labeled Clozapine. Clozapine is an antipsychotic used for the research of schizophrenia. Clozapine has high affinity for a number of neuroreceptors .
    Clozapine-d4
  • HY-17366R
    Clozapine N-oxide (Standard)

    		Reference Standards mAChR Dopamine Receptor Drug Metabolite Neurological Disease
    Clozapine N-oxide (Standard) is the analytical standard of Clozapine N-oxide. This product is intended for research and analytical applications. Clozapine N-oxide is a major metabolite of Clozapine and a human muscarinic designer receptors (DREADDs) agonist. Clozapine N-oxide activates the DREADD receptor hM3Dq and hM4Di. Clozapine N-oxide cannot cross the blood-brain barrier[1][2][3][4]. Clozapine is a potent dopamine antagonist and also a potent and selective muscarinic M4 receptor (EC50=11 nM) agonist[5][6].
    Clozapine N-oxide (Standard)
  • HY-14539A
    Clozapine hydrochloride
    10+ Cited Publications

    HF 1854 hydrochloride

    		 Dopamine Receptor mAChR Adrenergic Receptor 5-HT Receptor Neurological Disease
    Clozapine hydrochloride (HF 1854 hydrochloride) is an antipsychotic used for the research of schizophrenia. Clozapine hydrochloride has high affinity for a number of neuroreceptors. Clozapine hydrochloride is a potent antagonist of dopamine D2 with a Ki of 75 nM. Clozapine hydrochloride inhibits the muscarinic M1 receptor and serotonin 5HT2A receptor with Kis of 9.5 nM and 4 nM, respectively . Clozapine hydrochloride is also a potent and selective agonist at the muscarinic M4 receptor (EC50=11 nM) .
    Clozapine hydrochloride
  • HY-14539S
    Clozapine-d8

    HF 1854-d8

    		 Dopamine Receptor mAChR Adrenergic Receptor 5-HT Receptor Neurological Disease
    Clozapine-d8 is the deuterium labeled Clozapine. Clozapine is an antipsychotic used for the research of schizophrenia. Clozapine has high affinity for a number of neuroreceptors .
    Clozapine-d8
  • HY-14539R
    Clozapine (Standard)
    10+ Cited Publications

    HF 1854 (Standard)

    		 Reference Standards Dopamine Receptor mAChR Adrenergic Receptor 5-HT Receptor Neurological Disease
    Clozapine (Standard) is the analytical standard of Clozapine. This product is intended for research and analytical applications. Clozapine (HF 1854) is an antipsychotic used for the research of schizophrenia. Clozapine has high affinity for a number of neuroreceptors. Clozapine is a potent antagonist of dopamine D2 with a Ki of 75 nM. Clozapine inhibits the muscarinic M1 receptor and serotonin 5HT2A receptor with Kis of 9.5 nM and 4 nM, respectively . Clozapine is also a potent and selective agonist at the muscarinic M4 receptor (EC50=11 nM) .
    Clozapine (Standard)
  • HY-131891
    JHU37152

    		mAChR Neurological Disease
    JHU37152 is a potent and brain-penetrant DREADD agonist, with EC50s of 5 nM and 0.5 nM for hM3Dq and hM4Di DREADDs in HEK-293 cells, respectively. JHU37152 exhibits selective [ 3H]Clozapine displacement from DREADDs and not from other Clozapine-binding sites in mice brain tissue .
    JHU37152
  • HY-106587A
    Octoclothepin maleate salt

    Clorotepine maleate salt

    		 Drug Derivative 5-HT Receptor Neurological Disease
    Octoclothepine (Clorotepine) maleate salt, an analog of Clozapine (HY-14539), is a neuroleptic and antipsychotic agent. Octoclothepine maleate salt exists in enantiomeric forms, where the (+)-form acts as an atypical antipsychotic, while the (-)-functions as a typical antipsychotic. (+)-Octoclothepine maleate salt exhibits extremely high binding affinity for 5-HT₆ and 5-HT₇ receptors, with Ki values of 0.41 and 0.38 nM; the Ki values of (-)-Octoclothepine maleate salt are 17.7 and 1.3 nM, respectively. Octoclothepine maleate salt can be used in research related to schizophrenia .
    Octoclothepin maleate salt
  • HY-42109
    Clozapine impurity 8

    		Drug Intermediate Others
    Clozapine impurity 8 is an impurity of Clozapine (HY-14539).
    Clozapine impurity 8
  • HY-W127671
    Tetramethylammonium perchlorate

    		Biochemical Assay Reagents Others
    Tetramethylammonium perchlorate is used as an intermediate in organic and chemical synthesis. It is used as mobile phase in HPLC analysis and quantification of olanzapine, clozapine and N-desmethylclozapine. It acts as a supporting electrolyte in the electrochemical reduction of 1-bromodecane, 1-iodododecane, 2-iodooctane, and 2-bromooctane on a mercury cathode.
    Tetramethylammonium perchlorate
  • HY-G0021S1
    N-Desmethylclozapine-d8 hydrochloride

    NorClozapine-d8 hydrochloride; DesmethylClozapine-d8 hydrochloride; NormethylClozapine-d8 hydrochloride

    		 mAChR Opioid Receptor Drug Metabolite Virus Protease Infection
    N-Desmethylclozapine-d8 (hydrochloride) is the deuterium labeled N-Desmethylclozapine hydrochloride. N-Desmethylclozapine hydrochloride is a major active metabolite of the atypical antipsychotic agent Clozapine. N-Desmethylclozapine hydrochloride is a potent, allosteric and partial M1 receptors agonist (EC50=115 nM) and is able to potentiate hippocampal N-methyl-d-aspartate (NMDA) receptor currents through M1 receptor activation. N-Desmethylclozapine hydrochloride is also a δ-opioid agonist .
    N-Desmethylclozapine-d8 hydrochloride
  • HY-168869
    Tamoxifen-PEG-Clozapine

    		PROTACs Estrogen Receptor/ERR Cancer
    Tamoxifen-PEG-Clozapine is an estrogen receptor α (ERα) PROTAC degrader. Tamoxifen-PEG-Clozapine degrades ERα via a ubiquitin-proteasome system that uses the ubiquitin protein ligase E3 component N-recognin 5. Tamoxifen-PEG-Clozapine can be used for the research of cancer . (Pink: ERα inhibitor (HY-W271653); Black: linker (HY-168870); Blue: CRBN Ligand (HY-G0021))
    Tamoxifen-PEG-Clozapine
  • HY-17366AR
    Clozapine N-oxide dihydrochloride (Standard)

    		Reference Standards mAChR Dopamine Receptor Drug Metabolite Neurological Disease
    Clozapine N-oxide (dihydrochloride) (Standard) is the analytical standard of Clozapine N-oxide (dihydrochloride). This product is intended for research and analytical applications. Clozapine N-oxide dihydrochloride is a major metabolite of Clozapine and a human muscarinic designer receptors (DREADDs) agonist. Clozapine N-oxide dihydrochloride activates the DREADD receptor hM3Dq and hM4Di. Clozapine N-oxide dihydrochloride can cross the blood-brain barrier[1][2][3][4]. Clozapine is a potent dopamine antagonist and also a potent and selective muscarinic M4 receptor (EC50=11 nM) agonist[5][6].
    Clozapine N-oxide dihydrochloride (Standard)
  • HY-165527
    S18327

    		Dopamine Receptor 5-HT Receptor Neurological Disease
    S18327 is a multi-target antipsychotic agent. S18327 exerts its efficacy by acting on multiple neurotransmitter systems in the brain, and it has antagonistic effects on dopamine receptors (particularly the D2 receptor) and 5-hydroxytryptamine 2A receptors (5-HT2A receptor). S18327 can counteract excessive dopamine activity and hypo-function of glutamate. S18327 exhibits a multi-parameter pharmacological profile that is highly similar to that of Clozapine (HY-14539). S18327 can produce the same discriminative stimulus as Clozapine, improve cognitive filtering deficits associated with schizophrenia, and display anxiolytic properties. S18327 has relatively weak affinity for histaminergic receptors and muscarinic receptors, which avoids the side effects of Clozapine .
    S18327
  • HY-G0021S
    N-Desmethylclozapine-d8

    NorClozapine-d8; DesmethylClozapine-d8; NormethylClozapine-d8

    		 mAChR Opioid Receptor Drug Metabolite Virus Protease Infection
    N-Desmethylclozapine-d8 is the deuterium labeled N-Desmethylclozapine. N-Desmethylclozapine is a major active metabolite of the atypical antipsychotic agent Clozapine. N-Desmethylclozapine is a potent, allosteric and partial M1 receptors agonist (EC50=115 nM) and is able to potentiate hippocampal N-methyl-d-aspartate (NMDA) receptor currents through M1 receptor activation. N-Desmethylclozapine is also a δ-opioid agonist .
    N-Desmethylclozapine-d8
  • HY-W748582
    Clozapine N-oxide-d8

    		Isotope-Labeled Compounds Dopamine Receptor mAChR Drug Metabolite Neurological Disease
    Clozapine N-oxide-d8 is the deuterium labeled Clozapine N-oxide (HY-17366). Clozapine N-oxide is a major metabolite of Clozapine and a human muscarinic designer receptors (DREADDs) agonist. Clozapine N-oxide activates the DREADD receptor hM3Dq and hM4Di. Clozapine N-oxide can't cross the blood-brain barrier . Clozapine is a potent dopamine antagonist and also a potent and selective muscarinic M4 receptor (EC50=11 nM) agonist .
    Clozapine N-oxide-d8
  • HY-14539B
    Clozapine dihydrochloride

    HF 1854 dihydrochloride

    		 Dopamine Receptor mAChR Adrenergic Receptor 5-HT Receptor Neurological Disease Cancer
    Clozapine (HF 1854) dihydrochloride is an antipsychotic used for the research of schizophrenia. Clozapine has high affinity for a number of neuroreceptors. Clozapine is a potent antagonist of dopamine D2 with a Ki of 75 nM. Clozapine inhibits the muscarinic M1 receptor and serotonin 5HT2A receptor with Kis of 9.5 nM and 4 nM, respectively . Clozapine is also a potent and selective agonist at the muscarinic M4 receptor (EC50=11 nM) .
    Clozapine dihydrochloride
  • HY-142592S
    Clozapine EP impurity D-d8

    		Drug Metabolite Isotope-Labeled Compounds Others
    Clozapine EP impurity D-d8 is the deuterium labeled Clozapine EP impurity D .
    Clozapine EP impurity D-d8
  • HY-14539S3
    Clozapine-d3

    HF 1854-d3

    		 Isotope-Labeled Compounds 5-HT Receptor Adrenergic Receptor Dopamine Receptor mAChR Neurological Disease Cancer
    Clozapine-d3 (HF 1854-d3) is deuterium labeled Clozapine. Clozapine (HF 1854) is an antipsychotic used for the research of schizophrenia. Clozapine has high affinity for a number of neuroreceptors. Clozapine is a potent antagonist of dopamine D2 with a Ki of 75 nM. Clozapine inhibits the muscarinic M1 receptor and serotonin 5HT2A receptor with Kis of 9.5 nM and 4 nM, respectively . Clozapine is also a potent and selective agonist at the muscarinic M4 receptor (EC50=11 nM) .
    Clozapine-d3
  • HY-180958
    Chlorohexane-PEG-clozapine

    		PROTACs Others
    Chlorohexane-PEG-clozapine is a HaloTag PROTAC degrader based on Clozapine (HY-14539). Chlorohexane-PEG-clozapine leads to a significant decrease in the luminescence intensity and protein level of Halo-Eluc .
    Chlorohexane-PEG-clozapine
  • HY-117083
    Clothiapine

    		5-HT Receptor Neurological Disease
    Clothiapine, an atypical antipsychotic agent, shares with clozapine its strong antiserotonergic properties .
    Clothiapine
  • HY-117083R
    Clothiapine (Standard)

    		5-HT Receptor Reference Standards Neurological Disease
    Clothiapine (Standard) is the analytical standard of Clothiapine. This product is intended for research and analytical applications. Clothiapine, an atypical antipsychotic agent, shares with clozapine its strong antiserotonergic properties .
    Clothiapine (Standard)
  • HY-W744029
    Clothiapine-d8

    		Isotope-Labeled Compounds 5-HT Receptor Neurological Disease
    Clothiapine-d8 is the deuterium labeled Clothiapine (HY-117083). Clothiapine, an atypical antipsychotic agent, shares with clozapine its strong antiserotonergic properties .
    Clothiapine-d8
  • HY-168870
    OH-PEG3-C2-Succinamic acid-2-(Methylamino)ethanol

    		PROTAC Linkers Others
    OH-PEG3-C2-Succinamic acid-2-(Methylamino)ethanol is a PROTAC Linker that can be used to synthesize PROTAC Tamoxifen-PEG-Clozapine (HY-168869) .
    OH-PEG3-C2-Succinamic acid-2-(Methylamino)ethanol
  • HY-168871
    E3 Ligase Ligand-linker Conjugate 161

    		E3 Ligase Ligand-Linker Conjugates Cancer
    E3 Ligase Ligand-linker Conjugate 161 is an E3 ligase ligand-linker conjugate. E3 Ligase Ligand-linker Conjugate 161 can be used to synthesize Tamoxifen-PEG-Clozapine (HY-168869) .
    E3 Ligase Ligand-linker Conjugate 161
  • HY-G0021R
    N-Desmethylclozapine (Standard)

    NorClozapine (Standard); DesmethylClozapine (Standard); NormethylClozapine (Standard)

    		 Reference Standards mAChR Opioid Receptor Drug Metabolite Virus Protease Infection
    N-Desmethylclozapine (Standard) is the analytical standard of N-Desmethylclozapine. This product is intended for research and analytical applications. N-Desmethylclozapine is a major active metabolite of the atypical antipsychotic agent Clozapine. N-Desmethylclozapine is a potent, allosteric and partial M1 receptors agonist (EC50=115 nM) and is able to potentiate hippocampal N-methyl-d-aspartate (NMDA) receptor currents through M1 receptor activation. N-Desmethylclozapine is also a δ-opioid agonist .
    N-Desmethylclozapine (Standard)
  • HY-W129146
    Clozapine impurity 2

    		Drug Intermediate Others
    Clozapine impurity 2 is an impurity of Clozapine.
    Clozapine impurity 2
  • HY-Z8493
    Clozapine impurity 1

    		Drug Intermediate Others
    Clozapine impurity 1 is an impurity of Clozapine.
    Clozapine impurity 1
  • HY-Z8494
    Clozapine impurity 3

    		Drug Intermediate Others
    Clozapine impurity 3 is an impurity of Clozapine.
    Clozapine impurity 3
  • HY-106587
    Octoclothepine

    Clorotepine

    		 5-HT Receptor Drug Derivative Neurological Disease
    Octoclothepine (Clorotepine), an analog of Clozapine (HY-14539), is a neuroleptic and antipsychotic agent. Octoclothepine exists in enantiomeric forms, where the (+)-form acts as an atypical antipsychotic, while the (-)-functions as a typical antipsychotic. (+)-Octoclothepine exhibits extremely high binding affinity for 5-HT₆ and 5-HT₇ receptors, with Ki values of 0.41 and 0.38 nM; the Ki values of (-)-Octoclothepine are 17.7 and 1.3 nM, respectively. Octoclothepine can be used in research related to schizophrenia .
    Octoclothepine

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