2369979-67-7
2369979-67-7
Chemical Structure
JHU37152
- CAS No.: 2369979-67-7
- Formula:C19H20ClFN4
- Molecular Weight:358.84
IUPAC Name: 8-chloro-11-(4-ethylpiperazin-1-yl)-1-fluoro-5H-dibenzo[b,e][1,4]diazepine
InChIKey: NZMZJNNWMSYDNX-UHFFFAOYSA-N
SMILES: FC1=C2C(NC3=CC=C(Cl)C=C3N=C2N4CCN(CC)CC4)=CC=C1
Biological Activity: JHU37152 is a potent and brain-penetrant DREADD agonist, with EC50s of 5 nM and 0.5 nM for hM3Dq and hM4Di DREADDs in HEK-293 cells, respectively. JHU37152 exhibits selective [3H]Clozapine displacement from DREADDs and not from other Clozapine-binding sites in mice brain tissue[1].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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JHU37152 | 99.72% | JHU37152 is a potent and brain-penetrant DREADD agonist, with EC50s of 5 nM and 0.5 nM for hM3Dq and hM4Di DREADDs in HEK-293 cells, respectively. JHU37152 exhibits selective [3H]Clozapine displacement from DREADDs and not from other Clozapine-binding sites in mice brain tissue. | ||||||||||||||||||||
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References
Keywords
